当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > M. leprae HSP18 suppresses copper (II) mediated ROS generation: Effect of redox stress on its structure and function.

M. leprae HSP18 suppresses copper (II) mediated ROS generation: Effect of redox stress on its structure and function.

Abstract：

:Mycobacterium leprae, causative organism of leprosy, is known to counter redox stress generated by reactive oxygen species (ROS) during its survival inside host macrophages. But, the involvement of any antigenic protein(s) for countering such redox stress is still unknown. Interestingly, M. leprae HSP18, an important antigenic protein that helps in the growth and survival of M. leprae pathogen inside host macrophages, is induced under redox stress. Moreover, HSP18 also interacts with Cu2+. Copper (II) can induce redox stress via Fenton reaction. But, whether HSP18 suppresses Cu2+ mediated ROS generation, is still far from clear. Also, the effect of redox stress on its structure and function is not known. In this study, we show that HSP18 efficiently suppresses Cu2+ mediated generation of ROS and also prevents the redox mediated aggregation of a client protein (γD-crystallin). Upon exposure to substantial redox stress, irreversible perturbation in the secondary and tertiary structure of HSP18 and the tryptophan and tyrosine oxidation are evidenced. Interestingly, HSP18 retains a considerable amount of functionality even after being exposed to substantial redox stress. Perhaps, the redox scavenging ability as well as the chaperone function of HSP18 may possibly help M. leprae pathogen to counter redox stress inside host macrophages.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Nandi SK,Chakraborty A,Panda AK,Biswas A

doi

10.1016/j.ijbiomac.2019.12.215

subject

Has Abstract

pub_date

2020-03-01 00:00:00

pages

648-660

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)36324-X

journal_volume

146

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Effects of various oil extraction methods on the gelatinization and retrogradation properties of starches isolated from tigernut (Cyperus esculentus) tuber meals.

    abstract：:Gelatinization and retrogradation characteristics of starches from tigernut (Cyperus esculentus) tuber before and after various oil extraction processes were studied in this investigation. The results indicated that starches isolated from tigernut tuber after the various oil extraction processes varied significantly i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.252

    authors： Liu HM,Yan YY,Liu XX,Ma YX,Wang XD

    更新日期：2020-08-01 00:00:00

  • Mechanical and biological properties of chitin/polylactide (PLA)/hydroxyapatite (HAP) composites cast using ionic liquid solutions.

    abstract：:This research investigates the potential development of lobster shell waste-derived chitin reinforced with poly(lactic acid) (PLA) and nano-hydroxyapatite (nHAP) into new materials with potentially superior mechanical and thermal properties for biomedical applications. The ionic liquid 1-ethyl-3-methylimidazolium acet...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.168

    authors： Chakravarty J,Rabbi MF,Chalivendra V,Ferreira T,Brigham CJ

    更新日期：2020-05-15 00:00:00

  • Preparation, characterization, and 3D printing verification of chitosan/halloysite nanotubes/tea polyphenol nanocomposite films.

    abstract：:In this study, chitosan/halloysite nanotubes/tea polyphenol (CS/HNTs/TP) nanocomposite films were prepared by the solution casting method. The scanning electron microscopy (SEM) result showed that the nanocomposite film with a CS/HNTs ratio of 6:4 and a TP content of 10% (C6H4-TP10) had a relatively smooth surface and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.253

    authors： Wang Y,Yi S,Lu R,Sameen DE,Ahmed S,Dai J,Qin W,Li S,Liu Y

    更新日期：2021-01-01 00:00:00

  • The development of advanced cellulosic fibres.

    abstract：:For the majority of the last century, commercial routes to regenerated cellulose fibres have coped with the difficulties of making a good cellulose solution by using an easy to dissolve derivative (e.g. xanthate in the case of viscose rayon) or complex (e.g. cuprammonium rayon). For the purposes of this paper, advance...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/0141-8130(96)81836-8

    authors： Woodings CR

    更新日期：1995-12-01 00:00:00

  • Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression.

    abstract：:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression. The potent modulatory effects of polysaccharides on the innate and adaptive immune system stimulate antitumor responses. In this study, a polysaccharide with an apparent molecular weight...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.153

    authors： Dong CX,Zhang WS,Sun QL,Jiang YJ,Fu Z,Zhang Y,Du J,Sun YX,Tao N,Yao Z

    更新日期：2018-08-01 00:00:00

  • Synthesis and characterization of a novel organosilane-functionalized chitosan nanocarrier as an efficient gene delivery system: Expression of green fluorescent protein.

    abstract：:Semi-essential arginine amino acid was selected to synthesis an organosilane linker for modifying chitosan biopolymer. The novel organosilane linker which was chemically synthesized by reaction of arginine with 3‑chloropropyl trimethoxy silane, covalently bonded to the chitosan amino group. The chemical structure of r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.145

    authors： Kashkouli KI,Torkzadeh-Mahani M,Mosaddegh E

    更新日期：2019-03-15 00:00:00

  • Stability of halophilic proteins: from dipeptide attributes to discrimination classifier.

    abstract：:To investigate the molecular features responsible for protein halophilicity is of great significance for understanding the structure basis of protein halo-stability and would help to develop a practical strategy for designing halophilic proteins. In this work, we have systematically analyzed the dipeptide composition ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.10.031

    authors： Zhang G,Huihua G,Yi L

    更新日期：2013-02-01 00:00:00

  • Extractions and rheological properties of polysaccharide from okra pulp under mild conditions.

    abstract：:This study investigated the extraction of polysaccharide from okra pulp (POP), its chemical components, and rheological properties. The results showed that the optimal extraction temperature, time, and the ration of water to material were 20-30 °C, 30 mins, and 150, respectively, giving a maximum yield of 29.4%. The P...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.01.163

    authors： Li Y,Wang X,Lv X,Wang X,Wang X,Cui J,Yan M

    更新日期：2020-04-01 00:00:00

  • Physicochemical stability of curcumin emulsions stabilized by Ulva fasciata polysaccharide under different metallic ions.

    abstract：:The aim of this research was to investigate the effect of metallic ions (Na+, Ca2+, K+ and Mg2+) on the physicochemical stability of curcumin emulsions stabilized by Ulva fasciata polysaccharide (UFP). Mean droplet diameter, PdI, zeta-potential, microscopic morphology, and rheological properties of curcumin emulsion s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.07.018

    authors： Shao P,Qiu Q,Chen H,Zhu J,Sun P

    更新日期：2017-12-01 00:00:00

  • Ultrafiltration isolation, hypoglycemic activity analysis and structural characterization of polysaccharides from Brasenia schreberi.

    abstract：:Brasenia schreberi (B. schreberi) is a rare and precious vegetable, which coat with a gelatinous mucilage. This study is aiming to investigate the relationship between structural characteristics and hypoglycemic activities of polysaccharides with different molecular weight (Mw) range. Three polysaccharides fractions, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.129

    authors： Feng S,Luan D,Ning K,Shao P,Sun P

    更新日期：2019-08-15 00:00:00

  • The properties, biotechnologies, and applications of antifreeze proteins.

    abstract：:By natural selection, organisms evolve different solutions to cope with extremely cold weather. The emergence of an antifreeze protein gene is one of the most momentous solutions. Antifreeze proteins possess an importantly functional ability for organisms to survive in cold environments and are widely found in various...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.03.040

    authors： Xiang H,Yang X,Ke L,Hu Y

    更新日期：2020-06-15 00:00:00

  • Optimized purification process of polysaccharides from Carex meyeriana Kunth by macroporous resin, its characterization and immunomodulatory activity.

    abstract：:The analytical hierarchy process (AHP) combined with response surface methodology (RSM) was used to optimize the purification conditions of crude polysaccharides from Carex meyeriana Kunth (CMKP) by macroporous resin. The optimal purification conditions as follows: elution volume of 2.74 BV, flow rate of 1.88 BV/h, an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.207

    authors： Hu Z,Zhou H,Li Y,Wu M,Yu M,Sun X

    更新日期：2019-07-01 00:00:00

  • Characterization and antioxidant activities of polysaccharides from the leaves of Lilium lancifolium Thunb.

    abstract：:In this study, LLP-1, LLP-2, and LLP-3 three novel polysaccharide fractions were purified from the leaves of Lilium lancifolium, and their physicochemical characterizations and antioxidant properties were investigated by chemical methods, high performance gel permeation chromatography (HPGPC), high performance liquid ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.07.028

    authors： Xu Z,Wang H,Wang B,Fu L,Yuan M,Liu J,Zhou L,Ding C

    更新日期：2016-11-01 00:00:00

  • Role of reducing terminals in unfractionated and low-molecular-mass heparins in causing free radical generation and loss of structure and activity of trypsin.

    abstract：:The role of both the length of saccharide chain and reducing terminals in the heparin molecule in causing oxidative effects on proteins was investigated by employing unfractionated and low-molecular-mass heparins (LMMH), with both intact and reduced reducing terminals on bovine trypsin. The effects of heparin were fou...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00072-0

    authors： Finotti P,Pagetta A,Corvaja C

    更新日期：1999-11-01 00:00:00

  • Thermal stability and enzymatic activity of RNase A in the presence of cationic gemini surfactants.

    abstract：:The thermal stability and enzymatic activity of bovine pancreatic ribonuclease A (RNase A) have been investigated in the presence of a homologous series of cationic gemini surfactants (alkanediyl-α,ω-bis(hydroxyethyl methyl hexadecyl ammonium bromide)). UV, circular dichorism and fluorescence spectroscopies have been ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.01.027

    authors： Amiri R,Bordbar AK,Laurents DV,Khosropour AR,Mohammadpoor-Baltork I

    更新日期：2012-05-01 00:00:00

  • Effect of clay content on morphology and processability of electrospun keratin/poly(lactic acid) nanofiber.

    abstract：:This research work has concerned the development of volatile organic compounds (VOCs) removal filters from biomaterials, based on keratin extracted from chicken feather waste and poly(lactic acid) (PLA) (50/50%w/w) blend. Clay (Na-montmorillonite) was also added to the blend solution prior to carrying out an electro-s...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.01.041

    authors： Isarankura Na Ayutthaya S,Tanpichai S,Sangkhun W,Wootthikanokkhan J

    更新日期：2016-04-01 00:00:00

  • Study of the cell responses in tantalum carbide nanoparticles-enriched polysaccharide composite hydrogel.

    abstract：:Salecan is a linear microbial polysaccharide obtained from the fermentation of Agrobacterium sp. ZX09. Salecan is suitable for the preparation of hydrogels for biomedical applications, given its prominent physicochemical and biological properties. Herein, we described a novel microwave-assisted polymerized composite h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.191

    authors： Hu X,Wang Y,Xu M

    更新日期：2019-08-15 00:00:00

  • Polysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities.

    abstract：:Impacts of hot water extraction (HWE), pressurized water extraction (PWE), high-speed shearing homogenization extraction, microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), ultrasound assisted enzymatic extraction, and ultrasound-microwave assisted extraction (UMAE) on physicochemical character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.273

    authors： Fu Y,Li F,Ding Y,Li HY,Xiang XR,Ye Q,Zhang J,Zhao L,Qin W,Gan RY,Wu DT

    更新日期：2020-03-01 00:00:00

  • The effect of hyaluronic acid hydrogels on dental pulp stem cells behavior.

    abstract：:Dental caries and trauma, particularly in childhood, are among the most prevalent teeth problems, which result in the creation of cavities and probably tooth loss. Thus, novel regenerative approaches with high efficiency and less toxicity are required. Stem cell therapy along with the implementation of scaffolds has p...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2019.08.119

    authors： Ahmadian E,Eftekhari A,Dizaj SM,Sharifi S,Mokhtarpour M,Nasibova AN,Khalilov R,Samiei M

    更新日期：2019-11-01 00:00:00

  • Chitosan-functionalized nanofibers: A comprehensive review on challenges and prospects for food applications.

    abstract：:Chitosan exhibits outstanding properties, which allow a wide range of applications. For this reason, chitosan-based biomaterials have been developed over the years and, among these biomaterials, chitosan-based nanomaterials may significantly change the material properties, which could result in some exceptional featur...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2018.11.042

    authors： de Farias BS,Sant'Anna Cadaval Junior TR,de Almeida Pinto LA

    更新日期：2019-02-15 00:00:00

  • Physicochemical studies on peroxynitrite-modified H3 histone.

    abstract：:Histones are DNA protective proteins and may adopt different structures under nitrosative stress. Peroxynitrite is a powerful oxidant and nitrating agent and has in vivo existence. In this communication, we report effect of peroxynitrite-mediated oxidation and nitration on the structure of calf thymus H3 histone. Fine...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.10.009

    authors： Dixit K,Khan MA,Sharma YD,Moinuddin,Alam K

    更新日期：2010-01-01 00:00:00

  • Overcoming stemness and chemoresistance in colorectal cancer through miR-195-5p-modulated inhibition of notch signaling.

    abstract：:MiR-195-5p has been shown to have a regulatory role in a variety of cancers. Its influence on colorectal cancer (CRC), however, has never been evaluated. In the present study, we found that miR-195-5p expression was significantly decreased as compared to paired, tumor-adjacent normal colorectal tissues. We demonstrate...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.151

    authors： Jin Y,Wang M,Hu H,Huang Q,Chen Y,Wang G

    更新日期：2018-10-01 00:00:00

  • Interactions of hyaluronan with oppositely charged surfactants in very diluted solutions in water.

    abstract：:The phase behavior of aqueous systems containing hyaluronan, at concentrations between 2 and 100 mg/L, and oppositely charged surfactants was investigated. A fluorescence probe technique revealed the formation of micellar structures on the hyaluronan in homogeneous systems well below the surfactant standard, critical,...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.176

    authors： Pilgrová T,Venerová T,Mravec F,Pekař M

    更新日期：2018-06-01 00:00:00

  • High resolution neutron fibre diffraction data on hydrogenated and deuterated cellulose.

    abstract：:High-resolution fibre neutron diffraction data were recorded from cellulose samples on a D19 diffractometer at the Institut Laue-Langevin (Grenoble). Highly crystalline cellulose I samples from Cladophora (cellulose I alpha + I beta) or Halocynthia (cellulose I beta) origin were prepared in the form of oriented films....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00094-x

    authors： Nishiyama Y,Okano T,Langan P,Chanzy H

    更新日期：1999-12-01 00:00:00

  • Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing.

    abstract：:A novel approach in fabricating anionic inter-polymeric complex polysaccharide bio-platform with enhanced mechanical, structural and chemical properties for burn wound dressings. This approach implies a facile, insitu method to design soft nano-floral inter-polymeric complexes. In particular, sodium alginate (SA) and ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.157

    authors： Zia T,Usman M,Sabir A,Shafiq M,Khan RU

    更新日期：2020-08-15 00:00:00

  • Structural and morphological evaluation of CNC reinforced PVA/Starch biodegradable films.

    abstract：:Nanocomposite films containing cellulose nanocrystals (CNC), as the reinforcing phase, and poly(vinyl alcohol) (PVA)/starch (S) blend, as the matrix, were prepared by solution casting technique. For the preparation, 5, 10, 15 wt% CNC suspension were incorporated in blends containing 90 wt% PVA/10 wt% S, 75 wt% PVA/25 ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.036

    authors： Popescu MC,Dogaru BI,Goanta M,Timpu D

    更新日期：2018-09-01 00:00:00

  • Improvement of immune responses to influenza vaccine (H5N1) by sulfated yeast beta-glucan.

    abstract：:In this study, the adjuvant activity of sulfated glucan from saccharomyces cerevisiae (SGSC) was investigated. sGSC had molecular weight of 12.9kDa and degrees of sulfation of 0.16. The effects of SGSC on the splenic lymphocyte cells of mice were measured in vitro. The results showed that SGSC could significantly prom...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.057

    authors： Wang M,Zhang L,Yang R,Fei C,Wang X,Zhang K,Wang C,Zheng W,Xue F

    更新日期：2016-12-01 00:00:00

  • Light scattering study of heat-denatured globular protein aggregates.

    abstract：:The structure of aggregates formed by the globular protein beta-lactoglobulin (beta-lg) after heat induced denaturation was studied using light scattering and size exclusion chromatography. The influence of varying the pH above the iso-electric point (pH 5.2) was investigated in the absence of added salt. Stable aggre...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.04.002

    authors： Mehalebi S,Nicolai T,Durand D

    更新日期：2008-08-15 00:00:00

  • The shelf life extension of refrigerated Nemipterus japonicus fillets by chitosan coating incorporated with propolis extract.

    abstract：:In this study, chitosan coatings incorporated with propolis extract (PE) were utilized to extend the shelf-life of refrigerated Nemipterus japonicus fillets. Microbiological (total mesophilic bacteria (TMB) and total psychrotrophic count (TPC)), physicochemical (pH, total volatile bases nitrogen (TVB-N), 2-thiobarbitu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.07.204

    authors： Ebadi Z,Khodanazary A,Hosseini SM,Zanguee N

    更新日期：2019-10-15 00:00:00

  • Mitochondrial genomes and 28S rDNA contradict the proposed obsoletion of the order Tetraonchidea (Platyhelminthes: Monogenea).

    abstract：:Due to the incongruence of morphology-based hypotheses and scarcity of molecular data, validity of the order Tetraonchidea remains contentious. The only complete mitogenome currently available for the entire order is that of Paratetraonchoides inermis (Tetraonchoididae). To study the phylogeny of Tetraonchidea from mi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.09.150

    authors： Zhang D,Li WX,Zou H,Wu SG,Li M,Jakovlić I,Zhang J,Chen R,Wang GT

    更新日期：2020-01-15 00:00:00