当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Improvement of immune responses to influenza vaccine (H5N1) by sulfated yeast beta-glucan.

Improvement of immune responses to influenza vaccine (H5N1) by sulfated yeast beta-glucan.

Abstract：

:In this study, the adjuvant activity of sulfated glucan from saccharomyces cerevisiae (SGSC) was investigated. sGSC had molecular weight of 12.9kDa and degrees of sulfation of 0.16. The effects of SGSC on the splenic lymphocyte cells of mice were measured in vitro. The results showed that SGSC could significantly promote lymphocyte proliferation singly or synergistically with Con A and LPS, and stimulate the cells to secrete IL-2 and INF-γ. The adjuvant activity of SGSC was researched in BALB/c mice inoculated with inactivated H5N1vaccine in vivo. The results showed that SGSC could significantly enhance lymphocyte proliferation, effectively increase the percentage of CD4+ T cells, decrease the percentage of CD8+ T cells, and elevate the CD4+/CD8+ ratio; enhance the HI antibody titre, and promote the production of IL-2, INF-γ, IL-4 and IL-6 at medium level. These results indicated that sulfated glucan showed an excellent adjuvant effect on H5N1vaccine in a mouse model. Therefore, SGSC could be used as an effective immune adjuvant for an inactivated H5N1vaccine.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Wang M,Zhang L,Yang R,Fei C,Wang X,Zhang K,Wang C,Zheng W,Xue F

doi

10.1016/j.ijbiomac.2016.06.057

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

203-207

issue

Pt A

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30595-5

journal_volume

93

pub_type

杂志文章

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