Abstract:
:Salecan is a linear microbial polysaccharide obtained from the fermentation of Agrobacterium sp. ZX09. Salecan is suitable for the preparation of hydrogels for biomedical applications, given its prominent physicochemical and biological properties. Herein, we described a novel microwave-assisted polymerized composite hydrogel that was comprised of salecan/poly(diacetone acrylamide) (PDAAm) network and tantalum carbide (TaC) nanoparticles. The incorporation of TaC nanoparticles into the composite hydrogels was confirmed by XRD and EDX analysis, and can be engineered as means for structural reinforcement, thus leading to a remarkable improvement in their thermal stability and mechanical properties. Compared to bare salecan/PDAAm hydrogel, >9.3-fold increase in compressive modulus and 7-fold increase in storage modulus were achieved with the addition of 3 mL of TaC nanoparticles dispersion (5%, w/v). More importantly, cytotoxicity results revealed that the composite hydrogels were non-toxic to L929 and 3T3-L1 cells. Cell proliferation and Live/Dead staining demonstrated that salecan/PDAAm/TaC composite hydrogels provided a desired environment for cell adhesion, and allowed proliferation at the normal rate. All the results highlight the value of this system for potential application as cell adhesion material.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Hu X,Wang Y,Xu Mdoi
10.1016/j.ijbiomac.2019.05.191subject
Has Abstractpub_date
2019-08-15 00:00:00pages
501-511eissn
0141-8130issn
1879-0003pii
S0141-8130(19)31423-0journal_volume
135pub_type
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