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Structural characterization of a pectin-type polysaccharide from Curcuma kwangsiensis and its effects on reversing MDSC-mediated T cell suppression.

Abstract：

:Myeloid-derived suppressor cells (MDSCs) accumulate in tumor-bearing hosts and play a major role in tumor-induced immunosuppression. The potent modulatory effects of polysaccharides on the innate and adaptive immune system stimulate antitumor responses. In this study, a polysaccharide with an apparent molecular weight of 14.0 kD was isolated from Curcuma kwangsiensis and designated as CKAP-2. The polysaccharide was characterized through high-performance gel permeation chromatography, chemical derivative analyses, GC-MS, FT-IR, and NMR. Results revealed that CKAP-2 is a highly methyl-esterified pectin-type polysaccharide. It is predominantly composed of a homogalacturonan region and small amounts of type-I rhamonogalacturonan regions. Its degree of methyl-esterification is approximately 62.4%. The effect of CKAP-2 on MDSC-medicated immunosuppression was primarily tested. CKAP-2 recovered the MSC2-supressed proliferation of CD4+ and CD8+ T-cells. This finding suggested that CKAP-2 can reverse MDSC-mediated T-cell suppression and that CKAP-2 can be potentially applied in antitumor therapy.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Dong CX,Zhang WS,Sun QL,Jiang YJ,Fu Z,Zhang Y,Du J,Sun YX,Tao N,Yao Z

doi

10.1016/j.ijbiomac.2018.04.153

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1233-1240

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)30731-1

journal_volume

115

pub_type

杂志文章

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