当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Date palm (Phoenix dactylifera L.) fruit's polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes.

Date palm (Phoenix dactylifera L.) fruit's polyphenols as potential inhibitors for human amylin fibril formation and toxicity in type 2 diabetes.

Abstract：

BACKGROUND:β-Cell death is the key feature of type 2 diabetes mellitus (T2DM). The misfolding of human Islet Amyloid Polypeptide (hIAPP) is regarded as one of the causative factors of T2DM. Recent studies suggested that a diet based on date fruits presents various health benefits, as these fruits are naturally enriched in plant polyphenols. METHOD:In this study, we used a broad biophysical approach, using cell biology techniques and bioinformatic tools, to demonstrate that various polyphenols from date palm (Phoenix dactylifera L.) fruit significantly inhibited hIAPP aggregation and cytotoxicity. RESULT:Our results suggest that all of the polyphenols showed inhibitory effects, albeit varied, on the formation of toxic hIAPP amyloids. Correlation between cell viability assay, permeabilization of synthetic phospholipid vesicles tests, and ANS florescence measurements, revealed that both classes of polyphenols protected INS-1E cells from the toxicity of amylin aggregates. Docking results showed that the used polyphenols physically interacted with both hIAPP amyloidogenic region (residues Ser20-Ser29) and the non-amyloidogenic regions via hydrophobic and hydrogen interactions, thus reducing aggregation levels. CONCLUSION:These findings highlight the benefits of consuming dates and the great potential of its polyphenols as a potential therapy for the prevention and treatment of T2DM as well as for many other amyloid-related diseases.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chaari A,Abdellatif B,Nabi F,Khan RH

doi

10.1016/j.ijbiomac.2020.08.080

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

1794-1808

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)34170-2

journal_volume

164

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Cell wall metabolism and autolytic activities of the yeast Saccharomyces exiguus.

    abstract：:Autolytic activities were measured in cell walls prepared from the yeast Saccharomyces exiguus. Walls of yeast cells exhibited higher autolytic activities directed toward glucans at the exponential phase of growth when compared to cells at the stationary phase, while glucanase activities in the soluble extract fractio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(97)00034-2

    authors： Inouhe M,Sugo E,Tohoyama H,Joho M,Nevins DJ

    更新日期：1997-08-01 00:00:00

  • Interactions and compatibility of 11 S globulin from Vicia faba seeds and sodium salt of carboxymethylcellulose in an aqueous medium.

    abstract：:This work studies specific interactions and compatibility between a legumin and a linear carboxylated polysaccharide using gel permeation chromatography, sedimentation analysis, SDS gel electrophoresis, viscometry and phase analysis measurements. It uses the system water/11 S globulin/CMC as a model. Carboxymethylcell...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.011

    authors： Antonov YA,Dmitrochenko AP,Leontiev AL

    更新日期：2006-02-28 00:00:00

  • Formulation of extended release cefpodoxime proxetil chitosan-alginate beads using quality by design approach.

    abstract：:The purpose of this work was to develop and characterize chitosan-alginate beads for the extended delivery of cefpodoxime proxetil (CFP), to understand the impact of formulation and process parameters on the critical quality attributes (CQAs) using a quality-by-design approach. For this, a study was performed with var...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.05.066

    authors： Mujtaba A,Ali M,Kohli K

    更新日期：2014-08-01 00:00:00

  • Botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, reduces tumor development and cachexia syndrome in obese male rats by increasing insulin sensitivity and FOXO3a activity.

    abstract：:Obesity is an important risk factor in tumor development. Botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, produced by the fungus Botryosphaeria rhodina (MAMB-05), is a high molecular mass, water-soluble exopolysaccharide. It consists of a main chain of (1 → 3)-linked β-d-glucose units, with a degree of branching of ~22% ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.168

    authors： Geraldelli D,Ribeiro MC,Medeiros TC,Comiran PK,Martins KO,Oliveira MF,Oliveira GA,Dekker RFH,Barbosa-Dekker AM,Alegranci P,Queiroz EAIF

    更新日期：2020-12-15 00:00:00

  • Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis.

    abstract：:This study aimed to investigate the chemical characteristics and the effects of an orabase gel with Cashew Gum Polysaccharide (CG-P) from Anacardium occidentale L. on alveolar bone loss and relative mRNA expression of TNF-α, IL-1β, RANK, RANKL, and OPG in the periodontal tissue of Wistar rats (Rattus norvegicus) subje...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.09.087

    authors： Souza Filho MD,Medeiros JVR,Vasconcelos DFP,Silva DA,Leódido ACM,Fernandes HF,Silva FRP,França LFC,Lenardo D,Pinto GR

    更新日期：2018-02-01 00:00:00

  • Study of the selenizing Codonopsis pilosula polysaccharides protects RAW264.7 cells from hydrogen peroxide-induced injury.

    abstract：:Codonopsis pilosula polysaccharides (CPPS) has been shown to possess a variety of biological activities. In previous study, CPPS was successfully modified to obtain its best selenizing Codonopsis pilosula polysaccharides (sCPPS5). The purpose of this study was to investigate the protective effect of the selenizing der...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.025

    authors： Qin T,Ren Z,Liu X,Luo Y,Long Y,Peng S,Chen S,Zhang J,Ma Y,Li J,Huang Y

    更新日期：2019-03-15 00:00:00

  • Biological effects of formation of protein corona onto nanoparticle.

    abstract：:Administration of nanomaterials based medicinal and drug carrier systems into systemic circulation brings about interaction of blood components e.g. albumin and globulin proteins with these nanosystems. These blood or serum proteins either get loosely attached over these nanocarriers and form soft protein corona or ar...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2021.01.152

    authors： Mishra RK,Ahmad A,Vyawahare A,Alam P,Khan TH,Khan R

    更新日期：2021-01-25 00:00:00

  • Functional characterization of a type 2 metallothionein isoform (OsMTI-2b) from rice.

    abstract：:Metallothioneins (MTs) are a family of Cys-rich, low molecular weight, cytoplasmic metal binding proteins. MTs are present in all eukaryotes as well as some prokaryotes. Plant MTs are divided into four types based on Cys distribution pattern in their amino acid sequences. In the present work, the gene encoding OsMTI-2...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.04.021

    authors： Pirzadeh S,Shahpiri A

    更新日期：2016-07-01 00:00:00

  • Deep eutectic solvents as simultaneous plasticizing and crosslinking agents for starch.

    abstract：:The aim of this work was to prepare deep eutectic solvents (DES) made with choline salts with α-hydroxylate anions and glycerol and apply them as starch plasticizers. Additionally, crosslinking potential of polyfunctional anions from the salts was investigated. Starch/DES premixtures were rheologically and thermally (...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.103

    authors： Zdanowicz M,Jędrzejewski R,Pilawka R

    更新日期：2019-05-15 00:00:00

  • Polyhydroxyalkanoates based copolymers.

    abstract：:Polyhydroxyalkanoates (PHAs) belong to a family of natural polyesters and are produced under unbalanced growth conditions as intracellular carbon and energy reserves by a wide variety of microorganisms. Being biodegradable, biocompatible and environmental friendly thermoplastics, the PHAs are considered as future poly...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2019.08.147

    authors： Samui AB,Kanai T

    更新日期：2019-11-01 00:00:00

  • Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1.

    abstract：:In this study, in order to evaluate influences of different drying methods on the structural characteristics, physicochemical properties and antioxidant activities of exopolysaccharides (EPS) from Lactobacillus helveticus MB2-1, three drying methods, including spray-drying (SD), freeze-drying (FD) and spray freeze-dry...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.196

    authors： Xiao L,Li Y,Tian J,Zhou J,Xu Q,Feng L,Rui X,Fan X,Zhang Q,Chen X,Dong M,Li W

    更新日期：2020-08-15 00:00:00

  • Microwave synthesis, characterization, and zinc uptake studies of starch-graft-poly(ethylacrylate).

    abstract：:Microwave synthesis of starch-graft-poly(ethylacrylate) was optimized to obtain efficient Zn(II) adsorbent that has been characterized using IR, XRD and SEM analyses. Using the sample, adsorption of Zn(II) was studied as a function of pH, sorbent dose, initial Zn(II) concentration, % grafting, temperature and ionic st...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.05.023

    authors： Singh V,Maurya S

    更新日期：2010-10-01 00:00:00

  • Development of antibacterial ε-polylysine/chitosan hybrid films and the effect on citrus.

    abstract：:In this study, the ε-polylysine (PL)/chitosan (CS) composite films with the PL concentration of 0%, 1%, 3%, 5% and 7% were prepared via casting method. The Fourier transform infrared (FTIR), scanning electron microscope (SEM), mechanical and antibacterial properties of PL/CS composite films, as well as the effect of P...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.074

    authors： Li YN,Ye QQ,Hou WF,Zhang GQ

    更新日期：2018-10-15 00:00:00

  • Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of Citrus unshiu.

    abstract：:The extracts of the Citrus unshiu fruit induce numerous biological activities such as anticancer, anti-adipogenic, and antimicrobial effects. Furthermore, its peel has been used as a Chinese medicine for centuries and is consumed as a tea in China, Japan, and Korea. We investigated the effects of the polysaccharide is...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.02.006

    authors： Shin MS,Park SB,Shin KS

    更新日期：2018-06-01 00:00:00

  • Interaction of gentamicin sulfate with alginate and consequences on the physico-chemical properties of alginate-containing biofilms.

    abstract：BACKGROUND:Alginate is one of the main extracellular polymeric substances (EPS) in biofilms of Cystic Fibrosis (CF) patients suffering from pulmonary infections. Gentamicin sulfate (GS) can strongly bind to alginate resulting in loss of pharmacological activity; however neither the mechanism nor its repercussion is ful...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.025

    authors： Heriot M,Nottelet B,Garric X,D'Este M,Richards GR,Moriarty FT,Eglin D,Guillaume O

    更新日期：2019-01-01 00:00:00

  • SS-mPEG chemical modification of recombinant phospholipase C for enhanced thermal stability and catalytic efficiency.

    abstract：:PEGylation is one of the most promising and extensively studied strategies for improving the properties of proteins as well as enzymic physical and thermal stability. Phospholipase C, hydrolyzing the phospholipids offers tremendous applications in diverse fields. However, the poor thermal stability and higher cost of ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.01.134

    authors： Fang X,Wang X,Li G,Zeng J,Li J,Liu J

    更新日期：2018-05-01 00:00:00

  • Synergistic effects of nanochitin on inhibition of tobacco root rot disease.

    abstract：:Nanomaterials have great potential for use in various fields, due to their unique properties. In order to explore the bioactivity of nanochitin on tobacco, the effects of nanochitin suspensions on tobacco seed germination, seedling growth, and synergistic effects with fungicides were studied in indoor and field trials...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.02.069

    authors： Zhou Y,Jiang S,Jiao Y,Wang H

    更新日期：2017-06-01 00:00:00

  • WITHDRAWN: Nanomaterials Chemistry: Recent Developments and New Directions.

    abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published in Int. J. Biol. Macromol, doi:10.1016/j.ijbiomac.2008.07.012. The duplicate article has therefore been withdrawn. ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2008.08.002

    authors： Kennedy JF

    更新日期：2008-08-19 00:00:00

  • Temperature variation of the relaxation time of alpha-dispersion for gamma-irradiated collagen.

    abstract：:The effect of gamma irradiation, with doses from 10(2) to 10(3) kGy, on the dielectric relaxation time of solid-state collagen was studied. Temperature measurements of the relaxation time were made over a range of frequency of the electric field from 10(1) to 10(5) Hz and at temperatures from 298 to 480 K. The samples...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(95)93510-5

    authors： Marzec E

    更新日期：1995-02-01 00:00:00

  • Favorable chitosan/cellulose film combinations for copper removal from aqueous solutions.

    abstract：:Three well-formed film combinations of chitosan, in the beta form and cellulose acetate biopolymer, having different proportions, have been synthesized and characterized by X-ray diffraction and infrared spectroscopy. The film having a 1.0/0.50 proportion presented 6.87 mmol of nitrogen atoms per gram of synthesized h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.04.001

    authors： Lima IS,Lazarin AM,Airoldi C

    更新日期：2005-07-01 00:00:00

  • On the relationship between the conserved 'black' and 'gray' structural clusters and intrinsic disorder in parvalbumins.

    abstract：:Recently we found two highly conserved structural motifs in the members of the EF-hand protein family, which provide a supporting scaffold for their Ca2+ binding loops. Each structural motif is formed by a cluster of three amino acids. These clusters were called 'black' cluster (cluster I) and 'gray' cluster (cluster ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.183

    authors： Deryusheva EI,Denesyuk AI,Denessiouk K,Uversky VN,Permyakov SE,Permyakov EA

    更新日期：2018-12-01 00:00:00

  • Chemical and biological evaluation of Egyptian Nile Tilapia (Oreochromis niloticas) fish scale collagen.

    abstract：:Collagen is considered to be one of the most useful biomaterials with different medical applications. However, collagen properties differ from one source to another. The aim of this study was to extract, purify, characterize and perform preliminary biological evaluation of type I collagen from scales of Egyptian Nile ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.05.019

    authors： El-Rashidy AA,Gad A,Abu-Hussein Ael-H,Habib SI,Badr NA,Hashem AA

    更新日期：2015-08-01 00:00:00

  • Poly (A) binding protein enhances the binding affinity of potyvirus VPg to eukaryotic initiation factor eIF4F and activates in vitro translation.

    abstract：:Viral protein linked to the genome (VPg) of turnip mosaic virus (TuMV) interacts with eIF4F and plays an important role in cap-independent initiation of protein synthesis. In order to understand the importance of PABP on the interaction of eIF4F with VPg, we report that PABP enhanced the binding affinity ~3- and 4-fol...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.135

    authors： Khan MA,Goss DJ

    更新日期：2019-01-01 00:00:00

  • Chemical structure and anti-inflammatory effect of polysaccharides obtained from infusion of Sedum dendroideum leaves.

    abstract：:Sedum dendroideum is popularly known as balsam and used for treatment of inflammatory disorders. Two polysaccharides (RSBAL-H2O and RSBAL-0.5) were isolated from infusion of its dried leaves, using dialysis at 100kDa cut-off membrane and anion exchange chromatography. Methylation and NMR analyses showed that RSBAL-H2O...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.07.122

    authors： Oliveira AF,Nascimento GED,Iacomini M,Cordeiro LMC,Cipriani TR

    更新日期：2017-12-01 00:00:00

  • High-level expression and enzymatic properties of a novel thermostable xylanase with high arabinoxylan degradation ability from Chaetomium sp. suitable for beer mashing.

    abstract：:A novel thermostable xylanase gene from Chaetomium sp. CQ31 was cloned and codon-optimized (CsXynBop). The deduced protein sequence of the gene shared the highest similarity of 75% with the glycoside hydrolase (GH) family 10 xylanase from Achaetomium sp. Xz-8. CsXynBop was over-expressed in Pichia pastoris GS115 by hi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.040

    authors： Yu J,Liu X,Guan L,Jiang Z,Yan Q,Yang S

    更新日期：2021-01-31 00:00:00

  • Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin.

    abstract：:In this study, we prepared double cross-linked interpenetrating polymer network (IPN) hydrogels composed of temperature sensitive poly (N-isopropylacrylamide) (PNIPAM) and pH sensitive hyaluronic acid (HA) by radical polymerization and Michael addition. Their physicochemical properties for transdermal delivery of lute...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.06.061

    authors： Kim AR,Lee SL,Park SN

    更新日期：2018-10-15 00:00:00

  • Phenothiazine-chitosan based eco-adsorbents: A special design for mercury removal and fast naked eye detection.

    abstract：:The aim of the paper was to investigate the ability of an eco-friendly luminescent xerogel prepared by chitosan crosslinking with a phenothiazine luminogen to detect and remove heavy metals. Its ability to give a divergent morphological and optical response towards fifteen environmental relevant metals was investigate...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.232

    authors： Bejan A,Doroftei F,Cheng X,Marin L

    更新日期：2020-11-01 00:00:00

  • Identifying protein-protein interfacial residues in heterocomplexes using residue conservation scores.

    abstract：:Identifying protein-protein interfaces is crucial for structural biology. Because of the constraints in wet experiments, many computational methods have been proposed. Without knowing any information about the partner chains, a new method of predicting protein-protein interaction interface residues purely based on evo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2006.02.024

    authors： Li JJ,Huang DS,Wang B,Chen P

    更新日期：2006-05-30 00:00:00

  • Viscosity of alpha-crystallin solutions.

    abstract：:Accommodation in the mammalian lens requires flexure of lens fibres and some redistribution of their contents involving limited viscous flow. Shear-dependent viscosity of bovine alpha-crystallin solutions was determined with the Contraves Low-Shear Rheometer between 4.4 and 347 mg ml(-1), and at 15.5, 25, 30, and 37 d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00018-1

    authors： Tiffany JM,Koretz JF

    更新日期：2002-06-18 00:00:00

  • Protein-metallodrugs interactions: Effects on the overall protein structure and characterization of Au, Ru and Pt binding sites.

    abstract：:The effects of metalation process by inorganic compounds containing Au, Pt and Ru on protein structure and on conformation and flexibility of the residues involved in the metal compound binding have been here investigated by analysing 204 structures of protein/metallodrug adducts and the corresponding metal-free forms...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.07.053

    authors： Loreto D,Ferraro G,Merlino A

    更新日期：2020-11-15 00:00:00