当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin.

Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin.

Abstract：

:In this study, we prepared double cross-linked interpenetrating polymer network (IPN) hydrogels composed of temperature sensitive poly (N-isopropylacrylamide) (PNIPAM) and pH sensitive hyaluronic acid (HA) by radical polymerization and Michael addition. Their physicochemical properties for transdermal delivery of luteolin inhibiting the hyperproliferation of keratinocytes in psoriasis were investigated and drug release studies were performed. Double networks of HA/PNIPAM IPN hydrogel were identified through FT-IR and 13CNMR. By measuring the swelling ratios pH and temperature sensitivity were confirmed, and it was influenced by the content of a cross-linking agent. As a result of texture analysis and rheometry, a IPN hydrogel with 3% crosslinker content had the most adhesive and stable cross-linked network. Therefore, luteolin was loaded on this hydrogel. Its drug release behavior was determined at various temperatures and pH using several drug release kinetic models. As a result of skin permeation study, HA/PNIPAM IPN hydrogel effectively delivers luteolin to the epidermis and dermis. No toxicity was observed as a result of observing cytotoxicity of the hydrogel for application to the skin. In conclusion, IPN hydrogels can be developed as carriers of transdermal delivery system of luteolin for psoriasis skin relief.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kim AR,Lee SL,Park SN

doi

10.1016/j.ijbiomac.2018.06.061

subject

Has Abstract

pub_date

2018-10-15 00:00:00

pages

731-740

issue

Pt A

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)31511-3

journal_volume

118

pub_type

杂志文章

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