当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Mechanical and biological properties of chitin/polylactide (PLA)/hydroxyapatite (HAP) composites cast using ionic liquid solutions.

Mechanical and biological properties of chitin/polylactide (PLA)/hydroxyapatite (HAP) composites cast using ionic liquid solutions.

Abstract：

:This research investigates the potential development of lobster shell waste-derived chitin reinforced with poly(lactic acid) (PLA) and nano-hydroxyapatite (nHAP) into new materials with potentially superior mechanical and thermal properties for biomedical applications. The ionic liquid 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]) was used as a solvent to prepare chitin/PLA/nHAP composites. The effect of variation of the polymer concentrations on the conduct of the resulting composite was explored. The detailed physico-mechanical, thermal and surface morphology properties were evaluated with different thermal and optical characterization techniques. When the concentration of PLA in the composite was increased from 20 to 80 wt%, the tensile strength improved by ~77% while the elongation at break and the toughness of the material decreased significantly. The addition of hydroxyapatite was observed to improve strength of the composites up to 140% with an increase in elongation at break up to 465%. Cell growth study show that the composite materials support the growth and proliferation of Ocy 454 osteocyte cells. The materials were shown to have no effect on osteocyte gene expression, as well as minimal cytotoxicity and biodegradability. These results reveal that the biocomposites would be suitable candidates for use in bone regeneration that are not exposed to excessive forces.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chakravarty J,Rabbi MF,Chalivendra V,Ferreira T,Brigham CJ

doi

10.1016/j.ijbiomac.2019.10.168

subject

Has Abstract

pub_date

2020-05-15 00:00:00

pages

1213-1223

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)37859-6

journal_volume

151

pub_type

杂志文章

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