Abstract:
:Nanoparticles (NPs) have immense potential as drug-delivery carriers for cancer therapy due to their unique physicochemical properties. These particles can improve the pharmacological and therapeutic properties of the anti-cancer drugs by controlling release rates and targeted delivery process, which eliminate the limitations of conventional anti-cancer treatment methods. In recent years, chitosan-based NPs are emerging as one of the most promising delivery vehicles for cancer chemotherapy and diagnosis due to their unique characteristics such as biodegradability, biocompatibility, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent therapeutic unloading, ability to have a multi-functionality and prolonged circulating time. This article reviews the recent developments on the preparation, properties and tumor-targeted drug-delivery applications of NPs based on chitosan and its derivatives.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Prabaharan Mdoi
10.1016/j.ijbiomac.2014.10.052subject
Has Abstractpub_date
2015-01-01 00:00:00pages
1313-22eissn
0141-8130issn
1879-0003pii
S0141-8130(14)00732-6journal_volume
72pub_type
杂志文章,评审abstract::The aim of this study was to determine the antitumor and antiangiogenic effects of the Schisandra chinensis polysaccharides (SCP) in selected renal cell carcinoma (RCC) cells and evaluate its potential mechanism of action. In vitro, endothelial growth factor (VEGF) secretion by Caki-1 was blockaded in response to SCP ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2014.02.025
更新日期:2014-05-01 00:00:00
abstract::Herein, the immobilization of α-amylase onto hydroxyapatite (HA) and hydroxyapatite-decorated ZrO2 (10%wt) (HA-ZrO2) nanocomposite were investigated. The immobilization yield was 69.7% and 84% respectively. The structural differences were characterized using X-Ray diffraction, attenuated total reflectance-Fourier tran...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.11.150
更新日期:2021-01-15 00:00:00
abstract::Acetylated corn starch (ACS) was synthesized by the reaction of native corn starch (NCS) with acetic anhydride (AA) and acetic acid in an aqueous medium in the presence of p-toluenesulfonic acid (PTSA) as a catalyst. The factors that could affect the degree of substitution (DS) of corn starch were investigated which i...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2013.04.080
更新日期:2013-08-01 00:00:00
abstract::Codonopsis pilosula polysaccharide (CPPS) and selenizing CPPS (sCPPS) were prepared and identified by a combination of chemical and instrumental analysis. Their immune modulation activities were compared by lymphocyte proliferation and flowcytometry tests in vitro or serum antibody responses and cytokines with immuniz...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.05.149
更新日期:2020-10-01 00:00:00
abstract::The present study aimed to evaluate the antidepressant-like effect of a polysaccharide (OP), which is isolated from okra (Abelmoschus esculentus (L) Moench), in CUMS-induced mice and its possible mechanisms. OPT, FST and TST were employed to examine the anxiety and depressive behavior in CUMS-induced mice and fecal mi...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.12.138
更新日期:2020-02-01 00:00:00
abstract::The graft copolymer, chitosan-g-polyethylene glycol (PEG), was prepared through graft polymerization of PEG chains to chitosan due to the esterification reaction between PEG and 6-O-succinate-N-phthaloyl-chitosan (PHCSSA). The graft copolymer with porous structure was observed from scanning electron micrographs. It is...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2006.02.008
更新日期:2006-05-30 00:00:00
abstract::Forensic Science Laboratories usually receive numerous cases of suicidal, accidental, and homicidal poisoning most often involving organophosphorus (OP) pesticides. The toxicity of the OP pesticides arises due to their ability to inhibit the activity of acetylcholinesterase (AChE), a cholinergic enzyme that is essenti...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.08.215
更新日期:2020-12-01 00:00:00
abstract::Cordyceps cicadae is a traditional Chinese medicine with high nutritional value and biological activities. Previously, we reported on the antioxidant activity associated with the polysaccharides from Cordyceps cicadae (CP). To further explore which of the fraction of CP had the greatest potency, in here, the in vitro ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.04.163
更新日期:2020-08-15 00:00:00
abstract::This study was targeted to investigate the effect of chitosan-loaded nanoemulsion enriched with two types of essential oils on the microbial quality of turkey meat. To this end, the effects of essential oils of Zataria Multiflora Boiss (ZEO) and Bunium persicum Boiss (BEO) were evaluated at two concentrations (0.5% an...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.02.092
更新日期:2020-05-01 00:00:00
abstract::A water-soluble polysaccharide was isolated from marine green algae Ulva pertusa and then chelated with iron to prepare the polysaccharide‑iron (III) complex. The immunomodulatory activities of sulfated polysaccharide and polysaccharide‑iron (III) complex were investigated through a mice immune-deficiency model. Cyclo...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.04.101
更新日期:2019-07-15 00:00:00
abstract::The stability of enzymes with no reduction in their catalytic activity still remains a critical issue in industrial applications. Naturally occurring osmolytes are commonly used as protein stabilizers. In this study we have investigated the effects of sorbitol and trehalose on the structural stability and activity of ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2011.06.025
更新日期:2011-11-01 00:00:00
abstract::The aim of this study was to develop a new bioactive gelatin-oxidized starch nanofibers containing Lawsonia Inermis (henna) for treating second-degree burn wounds. Continuous, smooth, and bead-free fibers were obtained when the gelatin-starch ratio was 70/30.Additionally, the fiber dimeter was reduced with increasing ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.10.061
更新日期:2018-02-01 00:00:00
abstract::Heat shock proteins of 90kDa (Hsp90) are molecular chaperones essential for protein homeostasis. Besides chaperone activity, Hsp90 exhibits other cellular functions at membranes, yet how it interacts with membranes remains elusive. We report here that Hsp90B1 interacts with phospholipid membranes. We first cloned the ...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2017.08.121
更新日期:2018-01-01 00:00:00
abstract::The effects of metalation process by inorganic compounds containing Au, Pt and Ru on protein structure and on conformation and flexibility of the residues involved in the metal compound binding have been here investigated by analysing 204 structures of protein/metallodrug adducts and the corresponding metal-free forms...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.07.053
更新日期:2020-11-15 00:00:00
abstract::This research is aimed to develop cationic nanofibrous mats with improved cellular adhesion profiles and stability of three-dimensional fibrous structure as potential scaffolds for skin tissue engineering. Firstly, amino-remained chitosan-graft-poly (ɛ-caprolactone) (CS-g-PCL) was synthesized with a facile one-step ma...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2010.09.019
更新日期:2011-01-01 00:00:00
abstract::Herein, porous sodium alginate/graphite based hybrid hydrogel was fabricated as an effective adsorbent for organic pollutant. Sodium alginate was modified through graft polymerization of acrylic acid and subsequently loaded with graphite powder to enhance its adsorption capability. The synthesized sodium alginate cros...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.01.142
更新日期:2020-04-01 00:00:00
abstract::Thyroid hormone receptor interactor 13 (TRIP13) has been reported to be overexpressed in serval types of human cancers, and regulate tumor cell proliferation, migration and invasion. However, the role of TRIP13 in prostate cancer was still unclear. In our study, the correlation between TRIP13 expression and clinical p...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2018.09.168
更新日期:2019-01-01 00:00:00
abstract::In recent years, aging has been reported to be regulated by HAT. In this study, the inhibitory effects of spermidine on the matrix metalloproteinase-2 (MMP-2) activity and expression were investigated in human dermal fibroblasts (HDFs). It was observed that spermidine inhibits MMP-2 activity and expression. In additio...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2012.08.013
更新日期:2012-12-01 00:00:00
abstract::In this paper, the composition and biological activities of polysaccharides from Inula britannica flower IBP obtained by water extraction were investigated. The properties and chemical compositions of IBP were analyzed with HPLC and IR methods. The results showed that IBP consisted of two kinds of polysaccharides with...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2012.06.021
更新日期:2012-11-01 00:00:00
abstract::Double hydrophilic thermo-responsive pullulan-g-poly(N-isopropylacrylamide) (P-g-pNIPAM) copolymers with two different molecular weight of thermosensitive grafts were synthesized and used for preparation of indomethacin-loaded nanoparticles by dialysis and nanoprecipitation method. The polymers form aggregates in aque...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2016.10.064
更新日期:2017-01-01 00:00:00
abstract::A series of negatively charged macromolecules (NCMs) including poly (sulfonated styrene-co-methyl methacrylate) (P(SS-co-MMA)), poly (acrylic acid-co-methyl methacrylate) (P(AA-co-MMA)) and poly (sulfonated styrene-co-acrylic acid-co-methyl methacrylate) (P(SS-co-AA-co-MMA)) are synthesized by reversible addition frag...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2013.01.014
更新日期:2013-04-01 00:00:00
abstract::Biodegradable films composed of starch and chitosan plasticized by palm oil were fabricated via a solvent casting technique. In this study, the influence of the ratio of brown rice starch and chitosan on the mechanical, thermal, antimicrobial, and morphological properties of the films was investigated. Antimicrobial f...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.04.039
更新日期:2020-08-01 00:00:00
abstract::Arginine kinase (AK), a crucial enzyme in energy metabolism, buffers cellular ATP levels by catalyzing the reversible phosphoryl transfer between ATP and arginine. To better understand the role of Cys271 in conformational changes of AK from greasyback shrimp (Metapenaeus ensis), we replaced the residue with serine and...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2011.04.002
更新日期:2011-07-01 00:00:00
abstract::In this study, inhibitory kinetics of Nuciferine and Methyl Ganoderate extrated from Lotus Leaves and Ganoderma lucidum on Mucor miehei Lipase were studied first. The molecular structure of Nuciferine and Methyl Ganoderate were determined. The inhibitory effects of two extracts on lipase were reversible, with the IC50...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.09.127
更新日期:2020-11-15 00:00:00
abstract::Two cucumber F1 cultivar hybrids were investigated for stress tolerance markers upon application of different strength of Hoagland fertigation solutions (HG). 'Joker' and 'Oitol' cultivar hybrids were studied, representing typically field grown and greenhouse cultivated genotypes, respectively. At standard fertigation...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.06.050
更新日期:2020-10-15 00:00:00
abstract::In this study, chitosan and gelatin materials incorporated with grape seed (Vitis vinifera L.) (VSE) and jabuticaba peel (Plinia cauliflora) (PPE) extracts were developed with potential application as food coatings. It was evaluated how the concentration of the extracts and their addition order in the polymeric matrix...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.05.240
更新日期:2020-10-01 00:00:00
abstract::An edible hydroxypropyl starch (HPS) based bilayer film with a waterproof layer of zein was successfully prepared through a two-step solvent casting method. The morphology, mechanical properties, as well as water barrier properties of the bilayer film were systematically studied. Results showed that bilayer film prese...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.08.240
更新日期:2019-12-01 00:00:00
abstract::Microwave synthesis of starch-graft-poly(ethylacrylate) was optimized to obtain efficient Zn(II) adsorbent that has been characterized using IR, XRD and SEM analyses. Using the sample, adsorption of Zn(II) was studied as a function of pH, sorbent dose, initial Zn(II) concentration, % grafting, temperature and ionic st...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2010.05.023
更新日期:2010-10-01 00:00:00
abstract::In this study, in order to evaluate the influences of drying methods on the chemical structures and bioactivities of polysaccharides from okra (OPPs), four drying methods, including microwave drying at 400 W, 600 W, and 800 W, freezing drying, hot air drying, and vacuum drying, were applied to dry okra fruits. Six dif...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2019.10.073
更新日期:2020-03-15 00:00:00
abstract::A set of fungal polysaccharide samples was characterised by elemental analysis and FTIR spectroscopy and compared with reference chitins, chitosans and β-D-glucans. The nitrogen to carbon (N/C) values and FTIR spectra were used to compare the samples based on their composition. It was found that the N/C ratio correlat...
journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2015.05.059
更新日期:2015-09-01 00:00:00