Chitosan-based nanoparticles for tumor-targeted drug delivery.

Abstract:

:Nanoparticles (NPs) have immense potential as drug-delivery carriers for cancer therapy due to their unique physicochemical properties. These particles can improve the pharmacological and therapeutic properties of the anti-cancer drugs by controlling release rates and targeted delivery process, which eliminate the limitations of conventional anti-cancer treatment methods. In recent years, chitosan-based NPs are emerging as one of the most promising delivery vehicles for cancer chemotherapy and diagnosis due to their unique characteristics such as biodegradability, biocompatibility, remarkable cell membrane penetrability, high drug-carrying capacities, pH-dependent therapeutic unloading, ability to have a multi-functionality and prolonged circulating time. This article reviews the recent developments on the preparation, properties and tumor-targeted drug-delivery applications of NPs based on chitosan and its derivatives.

journal_name

Int J Biol Macromol

authors

Prabaharan M

doi

10.1016/j.ijbiomac.2014.10.052

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

1313-22

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00732-6

journal_volume

72

pub_type

杂志文章,评审
  • Antitumor and antiangiogenic activity of Schisandra chinensis polysaccharide in a renal cell carcinoma model.

    abstract::The aim of this study was to determine the antitumor and antiangiogenic effects of the Schisandra chinensis polysaccharides (SCP) in selected renal cell carcinoma (RCC) cells and evaluate its potential mechanism of action. In vitro, endothelial growth factor (VEGF) secretion by Caki-1 was blockaded in response to SCP ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.02.025

    authors: Qu HM,Liu SJ,Zhang CY

    更新日期:2014-05-01 00:00:00

  • Hydroxyapatite-decorated ZrO2 for α-amylase immobilization: Toward the enhancement of enzyme stability and reusability.

    abstract::Herein, the immobilization of α-amylase onto hydroxyapatite (HA) and hydroxyapatite-decorated ZrO2 (10%wt) (HA-ZrO2) nanocomposite were investigated. The immobilization yield was 69.7% and 84% respectively. The structural differences were characterized using X-Ray diffraction, attenuated total reflectance-Fourier tran...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.11.150

    authors: Almulaiky YQ,Khalil NM,El-Shishtawy RM,Altalhi T,Algamal Y,Aldhahri M,Al-Harbi SA,Allehyani ES,Bilal M,Mohammed MM

    更新日期:2021-01-15 00:00:00

  • Synthesis, optimization and characterization of acetylated corn starch with the high degree of substitution.

    abstract::Acetylated corn starch (ACS) was synthesized by the reaction of native corn starch (NCS) with acetic anhydride (AA) and acetic acid in an aqueous medium in the presence of p-toluenesulfonic acid (PTSA) as a catalyst. The factors that could affect the degree of substitution (DS) of corn starch were investigated which i...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2013.04.080

    authors: Han F,Gao C,Liu M,Huang F,Zhang B

    更新日期:2013-08-01 00:00:00

  • The structural characterization and immune modulation activitives comparison of Codonopsis pilosula polysaccharide (CPPS) and selenizing CPPS (sCPPS) on mouse in vitro and vivo.

    abstract::Codonopsis pilosula polysaccharide (CPPS) and selenizing CPPS (sCPPS) were prepared and identified by a combination of chemical and instrumental analysis. Their immune modulation activities were compared by lymphocyte proliferation and flowcytometry tests in vitro or serum antibody responses and cytokines with immuniz...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.05.149

    authors: Gao Z,Zhang C,Jing L,Feng M,Li R,Yang Y

    更新日期:2020-10-01 00:00:00

  • Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota.

    abstract::The present study aimed to evaluate the antidepressant-like effect of a polysaccharide (OP), which is isolated from okra (Abelmoschus esculentus (L) Moench), in CUMS-induced mice and its possible mechanisms. OPT, FST and TST were employed to examine the anxiety and depressive behavior in CUMS-induced mice and fecal mi...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.12.138

    authors: Yan T,Nian T,Liao Z,Xiao F,Wu B,Bi K,He B,Jia Y

    更新日期:2020-02-01 00:00:00

  • Preparation of chitosan derivative with polyethylene glycol side chains for porous structure without specific processing technique.

    abstract::The graft copolymer, chitosan-g-polyethylene glycol (PEG), was prepared through graft polymerization of PEG chains to chitosan due to the esterification reaction between PEG and 6-O-succinate-N-phthaloyl-chitosan (PHCSSA). The graft copolymer with porous structure was observed from scanning electron micrographs. It is...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2006.02.008

    authors: Huang M,Liu L,Zhang G,Yuan G,Fang Y

    更新日期:2006-05-30 00:00:00

  • Nano-interface driven electrochemical sensor for pesticides detection based on the acetylcholinesterase enzyme inhibition.

    abstract::Forensic Science Laboratories usually receive numerous cases of suicidal, accidental, and homicidal poisoning most often involving organophosphorus (OP) pesticides. The toxicity of the OP pesticides arises due to their ability to inhibit the activity of acetylcholinesterase (AChE), a cholinergic enzyme that is essenti...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.08.215

    authors: Singh AP,Balayan S,Hooda V,Sarin RK,Chauhan N

    更新日期:2020-12-01 00:00:00

  • Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae.

    abstract::Cordyceps cicadae is a traditional Chinese medicine with high nutritional value and biological activities. Previously, we reported on the antioxidant activity associated with the polysaccharides from Cordyceps cicadae (CP). To further explore which of the fraction of CP had the greatest potency, in here, the in vitro ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.04.163

    authors: Zhu Y,Yu X,Ge Q,Li J,Wang D,Wei Y,Ouyang Z

    更新日期:2020-08-15 00:00:00

  • Chitosan-loaded nanoemulsion containing Zataria Multiflora Boiss and Bunium persicum Boiss essential oils as edible coatings: Its impact on microbial quality of turkey meat and fate of inoculated pathogens.

    abstract::This study was targeted to investigate the effect of chitosan-loaded nanoemulsion enriched with two types of essential oils on the microbial quality of turkey meat. To this end, the effects of essential oils of Zataria Multiflora Boiss (ZEO) and Bunium persicum Boiss (BEO) were evaluated at two concentrations (0.5% an...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.02.092

    authors: Keykhosravy K,Khanzadi S,Hashemi M,Azizzadeh M

    更新日期:2020-05-01 00:00:00

  • Protective effects of Ulva pertusa polysaccharide and polysaccharide‑iron (III) complex on cyclophosphamide induced immunosuppression in mice.

    abstract::A water-soluble polysaccharide was isolated from marine green algae Ulva pertusa and then chelated with iron to prepare the polysaccharide‑iron (III) complex. The immunomodulatory activities of sulfated polysaccharide and polysaccharide‑iron (III) complex were investigated through a mice immune-deficiency model. Cyclo...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.04.101

    authors: Gao X,Qu H,Gao Z,Zeng D,Wang J,Baranenko D,Li Y,Lu W

    更新日期:2019-07-15 00:00:00

  • Effects of trehalose and sorbitol on the activity and structure of Pseudomonas cepacia lipase: spectroscopic insight.

    abstract::The stability of enzymes with no reduction in their catalytic activity still remains a critical issue in industrial applications. Naturally occurring osmolytes are commonly used as protein stabilizers. In this study we have investigated the effects of sorbitol and trehalose on the structural stability and activity of ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2011.06.025

    authors: Azizi A,Ranjbar B,Khajeh K,Ghodselahi T,Hoornam S,Mobasheri H,Ganjalikhany MR

    更新日期:2011-11-01 00:00:00

  • The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound.

    abstract::The aim of this study was to develop a new bioactive gelatin-oxidized starch nanofibers containing Lawsonia Inermis (henna) for treating second-degree burn wounds. Continuous, smooth, and bead-free fibers were obtained when the gelatin-starch ratio was 70/30.Additionally, the fiber dimeter was reduced with increasing ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.10.061

    authors: Hadisi Z,Nourmohammadi J,Nassiri SM

    更新日期:2018-02-01 00:00:00

  • Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes.

    abstract::Heat shock proteins of 90kDa (Hsp90) are molecular chaperones essential for protein homeostasis. Besides chaperone activity, Hsp90 exhibits other cellular functions at membranes, yet how it interacts with membranes remains elusive. We report here that Hsp90B1 interacts with phospholipid membranes. We first cloned the ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.08.121

    authors: Li P,Zhang M,Zou Y,Sun Z,Sun C,Geng Z,Xu W,Wang D

    更新日期:2018-01-01 00:00:00

  • Protein-metallodrugs interactions: Effects on the overall protein structure and characterization of Au, Ru and Pt binding sites.

    abstract::The effects of metalation process by inorganic compounds containing Au, Pt and Ru on protein structure and on conformation and flexibility of the residues involved in the metal compound binding have been here investigated by analysing 204 structures of protein/metallodrug adducts and the corresponding metal-free forms...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.07.053

    authors: Loreto D,Ferraro G,Merlino A

    更新日期:2020-11-15 00:00:00

  • Electrospun chitosan-graft-poly (ε -caprolactone)/poly (ε-caprolactone) cationic nanofibrous mats as potential scaffolds for skin tissue engineering.

    abstract::This research is aimed to develop cationic nanofibrous mats with improved cellular adhesion profiles and stability of three-dimensional fibrous structure as potential scaffolds for skin tissue engineering. Firstly, amino-remained chitosan-graft-poly (ɛ-caprolactone) (CS-g-PCL) was synthesized with a facile one-step ma...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2010.09.019

    authors: Chen H,Huang J,Yu J,Liu S,Gu P

    更新日期:2011-01-01 00:00:00

  • Graphite modified sodium alginate hydrogel composite for efficient removal of malachite green dye.

    abstract::Herein, porous sodium alginate/graphite based hybrid hydrogel was fabricated as an effective adsorbent for organic pollutant. Sodium alginate was modified through graft polymerization of acrylic acid and subsequently loaded with graphite powder to enhance its adsorption capability. The synthesized sodium alginate cros...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.01.142

    authors: Verma A,Thakur S,Mamba G,Prateek,Gupta RK,Thakur P,Thakur VK

    更新日期:2020-04-01 00:00:00

  • TRIP13 is a predictor for poor prognosis and regulates cell proliferation, migration and invasion in prostate cancer.

    abstract::Thyroid hormone receptor interactor 13 (TRIP13) has been reported to be overexpressed in serval types of human cancers, and regulate tumor cell proliferation, migration and invasion. However, the role of TRIP13 in prostate cancer was still unclear. In our study, the correlation between TRIP13 expression and clinical p...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.09.168

    authors: Dong L,Ding H,Li Y,Xue D,Li Z,Liu Y,Zhang T,Zhou J,Wang P

    更新日期:2019-01-01 00:00:00

  • Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs.

    abstract::In recent years, aging has been reported to be regulated by HAT. In this study, the inhibitory effects of spermidine on the matrix metalloproteinase-2 (MMP-2) activity and expression were investigated in human dermal fibroblasts (HDFs). It was observed that spermidine inhibits MMP-2 activity and expression. In additio...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2012.08.013

    authors: Park IH,Kim MM

    更新日期:2012-12-01 00:00:00

  • Composition and bioactivity of polysaccharides from Inula britannica flower.

    abstract::In this paper, the composition and biological activities of polysaccharides from Inula britannica flower IBP obtained by water extraction were investigated. The properties and chemical compositions of IBP were analyzed with HPLC and IR methods. The results showed that IBP consisted of two kinds of polysaccharides with...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2012.06.021

    authors: Hong T,Zhao J,Dong M,Meng Y,Mu J,Yang Z

    更新日期:2012-11-01 00:00:00

  • Smart nanoparticles based on pullulan-g-poly(N-isopropylacrylamide) for controlled delivery of indomethacin.

    abstract::Double hydrophilic thermo-responsive pullulan-g-poly(N-isopropylacrylamide) (P-g-pNIPAM) copolymers with two different molecular weight of thermosensitive grafts were synthesized and used for preparation of indomethacin-loaded nanoparticles by dialysis and nanoprecipitation method. The polymers form aggregates in aque...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.10.064

    authors: Constantin M,Bucătariu S,Stoica I,Fundueanu G

    更新日期:2017-01-01 00:00:00

  • Synthesized negatively charged macromolecules (NCMs) for the surface modification of anticoagulant membrane biomaterials.

    abstract::A series of negatively charged macromolecules (NCMs) including poly (sulfonated styrene-co-methyl methacrylate) (P(SS-co-MMA)), poly (acrylic acid-co-methyl methacrylate) (P(AA-co-MMA)) and poly (sulfonated styrene-co-acrylic acid-co-methyl methacrylate) (P(SS-co-AA-co-MMA)) are synthesized by reversible addition frag...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2013.01.014

    authors: Ran F,Nie S,Yin Z,Li J,Su B,Sun S,Zhao C

    更新日期:2013-04-01 00:00:00

  • Evaluation of the thermomechanical properties and biodegradation of brown rice starch-based chitosan biodegradable composite films.

    abstract::Biodegradable films composed of starch and chitosan plasticized by palm oil were fabricated via a solvent casting technique. In this study, the influence of the ratio of brown rice starch and chitosan on the mechanical, thermal, antimicrobial, and morphological properties of the films was investigated. Antimicrobial f...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.04.039

    authors: Hasan M,Gopakumar DA,Olaiya NG,Zarlaida F,Alfian A,Aprinasari C,Alfatah T,Rizal S,Khalil HPSA

    更新日期:2020-08-01 00:00:00

  • The role of Cys271 in conformational changes of arginine kinase.

    abstract::Arginine kinase (AK), a crucial enzyme in energy metabolism, buffers cellular ATP levels by catalyzing the reversible phosphoryl transfer between ATP and arginine. To better understand the role of Cys271 in conformational changes of AK from greasyback shrimp (Metapenaeus ensis), we replaced the residue with serine and...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2011.04.002

    authors: Liu N,Wang JS,Wang WD,Pan JC

    更新日期:2011-07-01 00:00:00

  • Inhibitory kinetics and bioactivities of Nuciferine and Methyl Ganoderate on Mucor miehei lipase and 3T3-L1 preadipocytes.

    abstract::In this study, inhibitory kinetics of Nuciferine and Methyl Ganoderate extrated from Lotus Leaves and Ganoderma lucidum on Mucor miehei Lipase were studied first. The molecular structure of Nuciferine and Methyl Ganoderate were determined. The inhibitory effects of two extracts on lipase were reversible, with the IC50...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.09.127

    authors: Liu XT,Liu TT,Xu HL,Chen QX,Wang Q

    更新日期:2020-11-15 00:00:00

  • Oxidative stress level and dehydrin gene expression pattern differentiate two contrasting cucumber F1 hybrids under high fertigation treatment.

    abstract::Two cucumber F1 cultivar hybrids were investigated for stress tolerance markers upon application of different strength of Hoagland fertigation solutions (HG). 'Joker' and 'Oitol' cultivar hybrids were studied, representing typically field grown and greenhouse cultivated genotypes, respectively. At standard fertigation...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.06.050

    authors: Oszlányi R,Mirmazloum I,Pónya Z,Szegő A,Jamal S,Bat-Erdene O,Papp I

    更新日期:2020-10-15 00:00:00

  • Chitosan and gelatin materials incorporated with phenolic extracts of grape seed and jabuticaba peel: Rheological, physicochemical, antioxidant, antimicrobial and barrier properties.

    abstract::In this study, chitosan and gelatin materials incorporated with grape seed (Vitis vinifera L.) (VSE) and jabuticaba peel (Plinia cauliflora) (PPE) extracts were developed with potential application as food coatings. It was evaluated how the concentration of the extracts and their addition order in the polymeric matrix...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.05.240

    authors: Rodrigues MÁV,Bertolo MRV,Marangon CA,Martins VDCA,Plepis AMG

    更新日期:2020-10-01 00:00:00

  • Development and characterization of a hydroxypropyl starch/zein bilayer edible film.

    abstract::An edible hydroxypropyl starch (HPS) based bilayer film with a waterproof layer of zein was successfully prepared through a two-step solvent casting method. The morphology, mechanical properties, as well as water barrier properties of the bilayer film were systematically studied. Results showed that bilayer film prese...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.08.240

    authors: Chen X,Cui F,Zi H,Zhou Y,Liu H,Xiao J

    更新日期:2019-12-01 00:00:00

  • Microwave synthesis, characterization, and zinc uptake studies of starch-graft-poly(ethylacrylate).

    abstract::Microwave synthesis of starch-graft-poly(ethylacrylate) was optimized to obtain efficient Zn(II) adsorbent that has been characterized using IR, XRD and SEM analyses. Using the sample, adsorption of Zn(II) was studied as a function of pH, sorbent dose, initial Zn(II) concentration, % grafting, temperature and ionic st...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2010.05.023

    authors: Singh V,Maurya S

    更新日期:2010-10-01 00:00:00

  • Influences of different drying methods on the structural characteristics and multiple bioactivities of polysaccharides from okra (Abelmoschus esculentus).

    abstract::In this study, in order to evaluate the influences of drying methods on the chemical structures and bioactivities of polysaccharides from okra (OPPs), four drying methods, including microwave drying at 400 W, 600 W, and 800 W, freezing drying, hot air drying, and vacuum drying, were applied to dry okra fruits. Six dif...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.10.073

    authors: Yuan Q,He Y,Xiang PY,Huang YJ,Cao ZW,Shen SW,Zhao L,Zhang Q,Qin W,Wu DT

    更新日期:2020-03-15 00:00:00

  • Distinction of fungal polysaccharides by N/C ratio and mid infrared spectroscopy.

    abstract::A set of fungal polysaccharide samples was characterised by elemental analysis and FTIR spectroscopy and compared with reference chitins, chitosans and β-D-glucans. The nitrogen to carbon (N/C) values and FTIR spectra were used to compare the samples based on their composition. It was found that the N/C ratio correlat...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2015.05.059

    authors: Gomba GK,Synytsya A,Švecová P,Coimbra MA,Čopíková J

    更新日期:2015-09-01 00:00:00