当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Machaerium acutifolium lectin alters membrane structure and induces ROS production in Candida parapsilosis.

Machaerium acutifolium lectin alters membrane structure and induces ROS production in Candida parapsilosis.

Abstract：

:Lectins are a group of widely distributed and structurally heterogeneous proteins of nonimmune origin. These proteins have the ability to interact with glycans present on cell surfaces and elicit diverse biological activities. Machaerium acutifolium lectin (MaL) is an N-acetyl-D-glucosamine-binding lectin that exhibits antinociceptive activity via transient receptor potential cation channel subfamily V member 1 (TRPV1). Lectins that have the ability to recognize and interact with N-acetyl-D-glucosamine residues are potential candidates for studies of fungicidal activity. In this work, we show that MaL has antifungal activity against Candida species, and we describe its mode of action towards Candida parapsilosis. MaL inhibited the growth of C. albicans and C. parapsilosis. However, MaL was more potent against C. parapsilosis. The candidacidal mode of action of MaL on C. parapsilosis involves enhanced cell permeabilization, alteration of the plasma membrane proton-pumping ATPase function (H+-ATPase), induction of oxidative stress, and DNA damage. MaL also exhibited antibiofilm activity and noncytotoxicity to Vero cells. These results indicate that MaL is a promising candidate for the future development of a new, natural, and safe drug for the treatment of infections caused by C. parapsilosis.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Dias LP,Santos ALE,Araújo NMS,Silva RRS,Santos MHC,Roma RR,Rocha BAM,Oliveira JTA,Teixeira CS

doi

10.1016/j.ijbiomac.2020.06.236

subject

Has Abstract

pub_date

2020-11-15 00:00:00

pages

19-25

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)33690-4

journal_volume

163

pub_type

杂志文章

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