Abstract：
:The essential amino acid l-tryptophan is naturally present in the body, and is also available as a water soluble dietary supplement. The feasibility of preparing enriched cellulose acetate (CA)-based fibres as a vehicle for therapeutic delivery of such biomolecules was investigated. A new ternary solvent system consisting of acetone: N,N-dimethylacetamide: methanol (2:1:2) has been demonstrated to permit the solution blending of CA with the water soluble l-tryptophan. Nanofibrous webs substantially free of structural defects were continuously produced with mean fibre diameters in the range of 520-1010nm, dependent on process parameters. Morphology and diameter of fibres were influenced by concentration of CA spinning solution, applied voltage and flow rates. The kinetic release profile of l-tryptophan from electrospun CA nanofibres was described by the pseudo-second order kinetic model. Fibres with mean diameter of 720nm provide both the highest initial desorption rate and rate constant, which was partially attributed to the low fibre diameter and high relative surface area, but also the fact that the 720nm fibres produced were the most bead-free, providing diffusion advantages over the fibres with lowest mean diameter (520nm). The feasibility of combining l-tryptophan within fibres provides a promising route for manufacture of transdermal delivery devices.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Ghorani B,Goswami P,Blackburn RS,Russell SJdoi
10.1016/j.ijbiomac.2017.11.124subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1-8eissn
0141-8130issn
1879-0003pii
S0141-8130(17)33951-Xjournal_volume
108pub_type
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