Aggregative protein-polyelectrolyte complex for high-concentration formulation of protein drugs.

Abstract:

:Aggregative protein-polyelectrolyte complex (PPC) has been proposed as a concentrated state of protein with a great potential for biopharmaceutical application. In this review article, we introduce a unique concentration method of protein formulation using PPC for a dozen types of pharmaceutical antibodies, hormones, and enzymes. Aggregative PPC can be obtained only by mixing poly(amino acid)s with proteins under low salt concentration conditions at an ambient temperature. The aggregative PPC is in a stabilized state against shaking, heating, and oxidation. More importantly, the aggregative PPC can be fully redissolved by the addition of physiological saline without denaturation and activity loss for many proteins. In addition, the general toxicity and pharmacokinetic profiles of the aggregative PPC are identical to those of the control antibody formulation. Thus, the protein formulation produced by aggregative PPC would be applicable for biomedical use as a kind of concentrated-state protein.

journal_name

Int J Biol Macromol

authors

Kurinomaru T,Shiraki K

doi

10.1016/j.ijbiomac.2016.06.016

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

11-17

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30542-6

journal_volume

100

pub_type

杂志文章,评审
  • α-Glucosidase inhibition by luteolin: kinetics, interaction and molecular docking.

    abstract::α-Glucosidase is a critical associated enzyme with type 2 diabetes mellitus in humans. Inhibition of α-glucosidase is important due to the potential effect of down regulating glucose absorption in patients. In this study, the inhibitory activity of flavone luteolin on α-glucosidase and their interaction mechanism were...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2013.12.007

    authors: Yan J,Zhang G,Pan J,Wang Y

    更新日期:2014-03-01 00:00:00

  • First evidence of formation of pre-molten globule state in myoglobin: A macromolecular crowding approach towards protein folding in vivo.

    abstract::Myoglobin is known to show formation of intermediate states under various environmental conditions, in spite of that, this is the first evidence of formation pre-molten globule (PMG) in myoglobin. Polyethylene glycol (PEG) of various molecular sizes shows assorted effects on different proteins. Out of too short and to...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.12.170

    authors: Parray ZA,Ahamad S,Ahmad F,Hassan MI,Islam A

    更新日期:2019-04-01 00:00:00

  • Bacterial cellulose nanofibers as reinforce in edible fish myofibrillar protein nanocomposite films.

    abstract::Bacterial cellulose nanofibers (BCNF) were employed in order to improve various properties of fish myofibrillar protein (FMP) films of Silver carp. Three different levels (2, 4 and 6%, w/w) of the nanoparticles were added to the protein polymer substrate. In this regard, it became clear that 6% BCNF-containing nanocom...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.05.038

    authors: Shabanpour B,Kazemi M,Ojagh SM,Pourashouri P

    更新日期:2018-10-01 00:00:00

  • Release of DNA from surfactant complexes induced by 2-hydroxypropyl-beta-cyclodextrin.

    abstract::Decompaction of DNA-CTA self-assembled complexes by 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) was studied and the results were compared with beta-CD. Different degrees of 2-HP substitution (0.6, 0.8 and 1.0, respectively) were used and the decompaction was successful with all degrees of substitution. Fluorescen...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2009.12.002

    authors: Carlstedt J,González-Pérez A,Alatorre-Meda M,Dias RS,Lindman B

    更新日期:2010-03-01 00:00:00

  • Effect of different combinations of maltodextrin, gum arabic and whey protein concentrate on the encapsulation behavior and oxidative stability of spray dried drumstick (Moringa oleifera) oil.

    abstract::The objective of the present study was to investigate the effect of different combinations of carrier agents (Maltodextrin, gum arabic and whey protein concentrate) on the emulsion properties, encapsulation efficiency and oxidative stability of encapsulated drumstick oil powder (EDOP), produced by spray drying to incr...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.07.160

    authors: Premi M,Sharma HK

    更新日期:2017-12-01 00:00:00

  • Isolation and characterization of lignocellulose nanofibers from different wheat straw pulps.

    abstract::Wheat straw was cooked under different pulping processes: Soda (100°C, 7% NaOH, 150min), Kraft (170°C, 16% alkalinity, 25% sulfidity, 40min) and Organosolv (210°C, 60% ethanol, 60min). Once the pulps were obtained, lignocellulose nanofibers (LCNF) were isolated by mechanical process and TEMPO-mediated oxidation follow...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.08.019

    authors: Sánchez R,Espinosa E,Domínguez-Robles J,Loaiza JM,Rodríguez A

    更新日期:2016-11-01 00:00:00

  • Multiple fingerprint profiles and chemometrics analysis of polysaccharides from Sarcandra glabra.

    abstract::Multiple techniques including high performance size-exclusion chromatography (HPSEC), Fourier-transform infrared spectroscopy (FT-IR) and pre-column derivatization high-performance liquid chromatography (PCD-HPLC) were applied to the fingerprint analysis of the polysaccharides from Sarcandra glabra (SGPs) in different...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.11.103

    authors: Li H,Gong X,Wang Z,Pan C,Zhao Y,Gao X,Liu W

    更新日期:2019-02-15 00:00:00

  • Mastoid obliteration using 3D PCL scaffold in combination with alginate and rhBMP-2.

    abstract::Various materials, both biological and alloplastic, have been used for mastoid obliteration after canal wall-down mastoidectomy in chronic otitis media. The purpose of this study is to investigate the osteoinductive potential of PCL scaffolds in mastoid obliteration, and to test that osteoinductivity can be enhanced b...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2013.10.011

    authors: Jang CH,Kim MS,Cho YB,Jang YS,Kim GH

    更新日期:2013-11-01 00:00:00

  • Development of antibacterial ε-polylysine/chitosan hybrid films and the effect on citrus.

    abstract::In this study, the ε-polylysine (PL)/chitosan (CS) composite films with the PL concentration of 0%, 1%, 3%, 5% and 7% were prepared via casting method. The Fourier transform infrared (FTIR), scanning electron microscope (SEM), mechanical and antibacterial properties of PL/CS composite films, as well as the effect of P...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.07.074

    authors: Li YN,Ye QQ,Hou WF,Zhang GQ

    更新日期:2018-10-15 00:00:00

  • Presence of N-L-lactyl-D-perosamine residue in the sheath-forming polysaccharide of Thiothrix fructosivorans.

    abstract::Thiothrix fructosivorans forms a microtube (sheath) that encloses a line of cells. This sheath is an assemblage of [→4)-GlcN-(1→4)-Glc-(1→]n with side chains of Rha4N-(1→3)-Fuc(1→ at position 3 of Glc. The sheath-forming polysaccharide (SFP) may have some substitutions but this is not yet confirmed. To investigate the...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2015.10.028

    authors: Kawasaki Y,Kondo K,Narizuka R,Endo T,Katahira M,Kawamura I,Sato M,Takeda M

    更新日期:2016-01-01 00:00:00

  • A systematic evaluation of hydroxyethyl starch as a potential nanocarrier for parenteral drug delivery.

    abstract::Development of parenteral nanoformulations is highly challenging due to the stringent demands on stability, reproducibility and high drug loading with minimal excipients. This study focuses on the development of a pharmaceutically acceptable nanomatrix system for parenteral delivery based on Hydroxyethyl Starch (HES),...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.12.012

    authors: Narayanan D,Nair S,Menon D

    更新日期:2015-03-01 00:00:00

  • Antitumor activity of polysaccharides from Lepista sordida against laryngocarcinoma in vitro and in vivo.

    abstract::Four water-soluble polysaccharides (LSPa1, LSPb1, LSPb2 and LSPc1) extracted from the fruiting bodies of Lepista sordida were prepared by DEAE cellulose-52 anion-exchange and Sepharose 6 Fast Flow gel-permeation chromatography. LSPa1 was composed of Glc, Man and Gal with a molar ratio of 3.2: 1.3: 0.6. LSPb1, LSPb2 an...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2013.05.033

    authors: Miao S,Mao X,Pei R,Miao S,Xiang C,Lv Y,Yang X,Sun J,Jia S,Liu Y

    更新日期:2013-09-01 00:00:00

  • G protein-coupled estrogen receptor (GPER) in adult boar testes, epididymis and spermatozoa during epididymal maturation.

    abstract::The G protein-coupled estrogen receptor (GPER) is a transmembrane receptor considered as a mediator of rapid non-genomic responses. GPER has been found in the male reproductive tract of many mammalian species. However, in adult boars, GPER has been reported only in ejaculated spermatozoa. Therefore, we focused on GPER...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.05.015

    authors: Krejčířová R,Maňasová M,Sommerová V,Langhamerová E,Rajmon R,Maňásková-Postlerová P

    更新日期:2018-09-01 00:00:00

  • Isolation, characterization and bioactivities of the polysaccharides from Dicliptera chinensis (L.) Juss.

    abstract::The polysaccharides of Dicliptera chinensis (L.) Juss. (DCP-1 and DCP-2) were extracted and isolated using the methods of water extract-ethanol precipitate and sephadex column chromatography and characterized by gel permeation chromatography (GPC), Fourier transform infrared spectrometry (FT-IR) and gas chromatography...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.03.112

    authors: Xu Y,Gao Y,Zhong M,Li J,Cao H,Huang S,Wei R,Zhang K

    更新日期:2017-08-01 00:00:00

  • The structure property and adsorption capacity of new enzyme-treated potato and sweet potato starches.

    abstract::To explore a valuable new enzyme method that effectively changes the molecular structure and absorption property of potato and sweet potato starch granules, the common combination of α-amylase (AA) and glucoamylase (GA), namely AA → GA (common method as contrast), the combination of glycosyltransferase (GT) and GA, na...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.09.164

    authors: Guo L,Li J,Li H,Zhu Y,Cui B

    更新日期:2020-02-01 00:00:00

  • Poly(vinyl chloride) blend with biodegradable cellulose acetate in presence of N-(phenyl amino) maleimides.

    abstract::Wider plastic applications of poly(vinyl chloride) (PVC) has raised serious problem to the environment. Since (PVC) waste products resist biodegradation and persist in the environment for longer time. The object of this study is to blend (PVC) with biodegradable cellulose acetate to thermally support the polymer durin...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.06.033

    authors: Abdel-Naby AS,Al-Ghamdi AA

    更新日期:2014-09-01 00:00:00

  • Rifampicin as a novel tyrosinase inhibitor: Inhibitory activity and mechanism.

    abstract::In this study, the inhibitory effect and mechanism of rifampicin on the activity of tyrosinase were investigated for developing a novel tyrosinase inhibitor. It was found to have a significant inhibition on the activity of tyrosinase (IC50=90±0.6μM). From the kinetics analysis, it was proved to be a reversible and non...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.04.058

    authors: Chai WM,Lin MZ,Song FJ,Wang YX,Xu KL,Huang JX,Fu JP,Peng YY

    更新日期:2017-09-01 00:00:00

  • Incorporating allylated lignin-derivatives in thiol-ene gel-polymer electrolytes.

    abstract::Growing environmental and economic concerns as well as the uncertainty that accompanies finite petrochemical resources contributes to the increase in research and development of bio-based, renewable polymers. Concurrently, industrial and consumer demand for smaller, safer, and more flexible technologies motivates a gl...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.02.160

    authors: Baroncini EA,Stanzione JF 3rd

    更新日期:2018-07-01 00:00:00

  • Structural analysis of water-soluble polysaccharides isolated from Panax notoginseng.

    abstract::Panax notoginseng is a widely used traditional Chinese medicine and has extensive pharmacological effects. In this work, water-soluble polysaccharides from Panax notoginseng were isolated and fractionated. One starch-like polysaccharide (PNPN) and six pectin fractions (PNPA-1A, PNPA-1B, PNPA-2A, PNPA-2B, PNPA-3A and P...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.03.233

    authors: Chan MK,Yu Y,Wulamu S,Wang Y,Wang Q,Zhou Y,Sun L

    更新日期:2020-07-15 00:00:00

  • Sodium alginate: An efficient biopolymeric catalyst for green synthesis of 2-amino-4H-pyran derivatives.

    abstract::Sodium alginate, a naturally occurring macromolecule, in its granular form and without any post-modification was found to be an efficient and recoverable bifunctional heterogeneous organocatalyst for the domino synthesis of various 2-amino-3-cyano-4H-pyran annulated derivatives through three-component condensation of ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.01.080

    authors: Dekamin MG,Peyman SZ,Karimi Z,Javanshir S,Naimi-Jamal MR,Barikani M

    更新日期:2016-06-01 00:00:00

  • Time-domain NMR relaxometry as an alternative method for analysis of chitosan-paramagnetic ion interactions in solution.

    abstract::Chitosan (CHI)-paramagnetic ion interactions in aqueous solution as affected by pH were studied using time-domain NMR (TD-NMR) relaxometry. Longitudinal (T1) and transverse (T2) relaxation times of CHI solutions with Fe3+, Cu2+, and Mn2+ were measured using a single-shot pulse sequence named CP-CWFPx-x. The results in...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.01.083

    authors: Kock FV,Monaretto T,Colnago LA

    更新日期:2017-05-01 00:00:00

  • Effect of salinity stress on bioactive compounds and antioxidant activity of wheat microgreen extract under organic cultivation conditions.

    abstract::This study was conducted to confirm the effects of salinity stress on bioactive compounds and antioxidant activity of wheat microgreen extract. The microgreens were cultivated for 8 days in organic media with different concentrations of Na [0 (control), 12.5, 25, 50, and 100 mM from sodium chloride] which was containe...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.08.090

    authors: Islam MZ,Park BJ,Lee YT

    更新日期:2019-11-01 00:00:00

  • Identification and characterization of a recombinant cognate hemoglobin reductase from Synechocystis sp. PCC 6803.

    abstract::One popular and relevant proposed function for cyanobacterial hemoglobin (Synechocystis Hb) is anaerobic nitrite reductase in vivo. During such reduction reactions, the hexacoordinated heme iron atom of SynHb is oxidized from the ferrous (Fe+2) to ferric (Fe+3) state and prevent damage by limiting the concentration of...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.06.214

    authors: Uppal S,Khan MA,Kundu S

    更新日期:2020-11-01 00:00:00

  • Crowded milieu tuning the stability and activity of stem bromelain.

    abstract::Proteins in vivo are under an extremely crowded environment because of the presence of bulky and large biological macromolecules (known as crowders). These crowders affect the proper functioning and structure of proteins in a cell. During in vitro studies, we often ignore the effect of macromolecular crowding on prote...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.12.060

    authors: Bhakuni K,Venkatesu P

    更新日期:2018-04-01 00:00:00

  • Kinetic and mechanistic considerations in the gelation of genipin-crosslinked gelatin.

    abstract::The gelling properties (gel time (t(gel)) and gel strength) of a 10% (w/w) gelatin sol were investigated as a function of genipin (GP) concentration (0-15 mM) and temperature (25-55 degrees C) to discern mechanisms and optimal conditions for fixation. Gel time increased with increasing temperature, reached a maximum, ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2006.04.010

    authors: Nickerson MT,Patel J,Heyd DV,Rousseau D,Paulson AT

    更新日期:2006-11-15 00:00:00

  • Role of Hsp90 and ATP in modulating apyrase activity and firefly luciferase kinetics.

    abstract::The present manuscript describes a novel bioassay consisting of apyrase and heat shock protein 90 (Hsp90) without additional co-chaperone supplementation; intended for high-throughput screening of anti-cancer drugs and prognosis of stress. In this regard, Hsp90 and adenosine 5'-triphosphate (ATP) mediated firefly luci...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.03.110

    authors: Kirillova MA,Ranjan R,Esimbekova EN,Kratasyuk VA

    更新日期:2019-06-15 00:00:00

  • Sustained release gastroretentive tablet of metformin hydrochloride based on poly (acrylic acid)-grafted-gellan.

    abstract::Development of a gastroretentive sustained release tablet of metformin based on poly (acrylic acid)-grafted-gellan (PAAc-g-GG) is the main purpose of this study. At first, PAAc-g-GG was synthesized by microwave-promoted free radical initiation method using cerric (IV) ammonium nitrate (CAN) as redox initiator and char...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.12.022

    authors: Sarkar D,Nandi G,Changder A,Hudati P,Sarkar S,Ghosh LK

    更新日期:2017-03-01 00:00:00

  • Antidepressant effects of a polysaccharide from okra (Abelmoschus esculentus (L) Moench) by anti-inflammation and rebalancing the gut microbiota.

    abstract::The present study aimed to evaluate the antidepressant-like effect of a polysaccharide (OP), which is isolated from okra (Abelmoschus esculentus (L) Moench), in CUMS-induced mice and its possible mechanisms. OPT, FST and TST were employed to examine the anxiety and depressive behavior in CUMS-induced mice and fecal mi...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2019.12.138

    authors: Yan T,Nian T,Liao Z,Xiao F,Wu B,Bi K,He B,Jia Y

    更新日期:2020-02-01 00:00:00

  • Kinetics of irreversible inhibition of yeast alcohol dehydrogenase during modification by 4,4'-dithiodipyridine.

    abstract::The course of inactivation of yeast alcohol dehydrogenase (YADH) using 4,4'-dithiodipyridine (DSDP) has been studied in this paper. The results show that the reaction mechanism between DSDP and YADH is a competitive, complexing inhibition. The microscopic constants for the inactivation of the free enzyme and the enzym...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/s0141-8130(97)00030-5

    authors: Zheng SY,Xu D,Wang HR,Li J,Zhou HM

    更新日期:1997-07-01 00:00:00

  • Rapid self-association of highly amyloidogenic H-fragments of insulin: Experiment and molecular dynamics simulations.

    abstract::The so-called 'H-fragment' of insulin is an extremely amyloidogenic double chain peptide consisting of the N-terminal parts of A-chain and B-chain linked by a disulfide bond between Cys-7A and Cys-7B. Here, we conduct a detailed investigation of the self-association behavior of H-fragment monomers into amyloid-like fi...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.02.153

    authors: Dec R,Koliński M,Kouza M,Dzwolak W

    更新日期:2020-05-01 00:00:00