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Chitosan-coated electrospun PLA fibers for rapid mineralization of calcium phosphate.

Abstract：

:In this work, hydroxyapatite (HA) mineralized on chitosan (CS)-coated poly(lactic acid) (PLA) nanofiber mat was prepared and compared in terms of mineralization characteristics. Significant calcium phosphate crystals formed on various concentrations of CS-coated PLA fiber mat with better uniformity after 2h of incubation in 10 times simulated body fluid (10× SBF). X-ray diffraction results further indicated that the composition of the deposited mineral was a mixture of dicalcium phosphate dehydrates and apatite. Chitosan, a cationic polysaccharide, can promote more nucleation and growth of calcium phosphate under conditions of 0.4% chitosan concentrations. These results indicated that HA-mineralized on CS-coated PLA fiber mat can be prepared directly via simply using CS coating followed by SBF immersion, and the results also suggest that this composite can mimic structural, compositional, and biological functions of native bone and can serve as a good candidate for bone tissue engineering (BTE).

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Lin CC,Fu SJ,Lin YC,Yang IK,Gu Y

doi

10.1016/j.ijbiomac.2014.04.039

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

39-47

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00266-9

journal_volume

68

pub_type

杂志文章

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