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Evaluation of microwave assisted grafted sago starch as controlled release polymeric carrier.

Abstract：

:In the present investigation an attempt has been made to develop a new co-polymeric material for controlled release tablet formulations. The acrylamide grafting was successfully performed on the backbone of sago starch. The modified starch was tested for acute toxicity and drug-excipient compatibility study. The grafted material was used in making of controlled release tablets of lamivudine. The formulations were evaluated for physical characteristics such as hardness, friability, %drug content and weight variations. The in vitro release study showed that the optimized formulation exhibited highest correlation (R) value in case of Higuchi model and the release mechanism of the optimized formulation predominantly exhibited combination of diffusion and erosion process. There was a significant difference in the pharmacokinetic parameters (T(max), C(max), AUC, V(d), T(1/2) and MDT) of the optimized formulation as compared to the marketed conventional tablet Lamivir(®) was observed. The pharmacokinetics parameters were showed controlled pattern and better bioavailability. The optimized formulation exhibited good stability and release profile at the accelerated stability conditions.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Singh AV,Nath LK

doi

10.1016/j.ijbiomac.2013.05.008

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

62-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00271-7

journal_volume

60

pub_type

杂志文章

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