当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties.

Nanoparticles based on crocin loaded chitosan-alginate biopolymers: Antioxidant activities, bioavailability and anticancer properties.

Abstract：

:Crocin, a water-soluble carotenoid in saffron, is a highly bioactive compound with limited use due to instability to pH variations, heat and oxidative stress, rapid absorption and low bioavailability. In this study, chitosan-alginate nanoparticles, considered as a new vehicle for crocin to improve properties in terms of antioxidant activity, bioavailability and anticancer activity. The swelling of crocin loaded nanoparticles was pH-dependent so that the highest swelling ratio (16g/g) was observed in acidic condition (pH=1.2) after 24h. The antioxidant activity of the crocin loaded nanoparticles was the same effective as pure crocin on DPPH free radical scavenging and ferric reducing ability of plasma (FRAP). In vitro crocin release profile from composite nanoparticles was investigated under simulated physiological conditions during incubation time. The experimental reports collected in this study strongly indicate that nanoparticles loaded with crocin could be the prospective candidates for the future anti-cancer therapeutics that deserve additional investigations.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Rahaiee S,Hashemi M,Shojaosadati SA,Moini S,Razavi SH

doi

10.1016/j.ijbiomac.2017.02.095

subject

Has Abstract

pub_date

2017-06-01 00:00:00

pages

401-408

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32516-8

journal_volume

99

pub_type

杂志文章

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