当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives.

Topoisomerase inhibition and albumin interaction studies of acridine-thiosemicarbazone derivatives.

Abstract：

:In the present study, acridine-thiosemicarbazones (ATD) derivatives were tested for their interaction properties with BSA through UV-Vis absorption and fluorescence spectroscopic studies. Both hyperchromic and hypochromic effects, as well as red or blue shifts were demonstrated after the derivatives were added to the BSA. Values for the binding constant (Kb) ranged from 1.62 × 104 to 8.71 × 105 M-1 and quenching constant (KSV) from 3.46 × 102 to 7.83 × 103 M-1 indicating a good affinity to BSA protein. Complementary, two compounds were selected to assess their inhibition activity against topoisomerase IIα enzyme, of which derivative 3a presented the best result. Moreover, to evaluate protein-ligand interactions, as well as the antitopoisomerase potential of these compounds, tests of molecular modeling were performed between all compounds using the albumin and Topoisomerase IIα/DNA complex. Finally, in silico studies showed that all derivatives used in this research displayed good oral bioavailability potential.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

da Silva Filho FA,de Freitas Souza T,Ribeiro AG,Alves JEF,de Oliveira JF,de Lima Souza TRC,de Moura RO,do Carmo Alves de Lima M,de Carvalho Junior LB,de Almeida SMV

doi

10.1016/j.ijbiomac.2019.07.097

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

582-589

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)33377-X

journal_volume

138

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications.

    abstract：:The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.06.104

    authors： Ghafari R,Jonoobi M,Amirabad LM,Oksman K,Taheri AR

    更新日期：2019-09-01 00:00:00

  • Characterization of α-D-glucan produced by a probiont Enterococcus hirae KX577639 from feces of south Indian Irula tribals.

    abstract：:Exopolysaccharide (EPS) producing probiotic strain Enterococcus hirae KX577639 were isolated from the feces of South Indian Irula tribes. EPS yield was 18.57 g/L (dry weight) at 48 h in 2% sucrose supplemented MRS medium. TLC and GC-MS analysis confirmed the presence of predominant glucose monomer indicating the homop...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.015

    authors： Jayamanohar J,Devi PB,Kavitake D,Rajendran S,Priyadarisini VB,Shetty PH

    更新日期：2018-10-15 00:00:00

  • Alginate-magnetic short nanofibers 3D composite hydrogel enhances the encapsulated human olfactory mucosa stem cells bioactivity for potential nerve regeneration application.

    abstract：:The design of 3D hydrogel constructs to elicit highly controlled cell response is a major field of interest in developing tissue engineering. The bioactivity of encapsulated cells inside pure alginate hydrogel is limited by its relatively inertness. Combining short nanofibers within a hydrogel serves as a promising me...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.199

    authors： Karimi S,Bagher Z,Najmoddin N,Simorgh S,Pezeshki-Modaress M

    更新日期：2021-01-15 00:00:00

  • Discovering and efficiently promoting the extracellular secretory expression of Thermobacillus sp. ZCTH02-B1 sucrose phosphorylase in Escherichia coli.

    abstract：:Sucrose phosphorylase (SPase, EC2.4.1.7) is a promising transglycosylation biocatalyst used for producing glycosylated compounds that are widely used in the food, cosmetics, and pharmaceutical industries. In this study, a recombinant SPase from the Thermobacillus sp. ZCTH02-B1 (rTSPase), which was previously reported ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2021.01.115

    authors： He X,Li Y,Tao Y,Qi X,Ma R,Jia H,Yan M,Chen K,Hao N

    更新日期：2021-01-19 00:00:00

  • Aggregative protein-polyelectrolyte complex for high-concentration formulation of protein drugs.

    abstract：:Aggregative protein-polyelectrolyte complex (PPC) has been proposed as a concentrated state of protein with a great potential for biopharmaceutical application. In this review article, we introduce a unique concentration method of protein formulation using PPC for a dozen types of pharmaceutical antibodies, hormones, ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2016.06.016

    authors： Kurinomaru T,Shiraki K

    更新日期：2017-07-01 00:00:00

  • A β-glucan from Grifola frondosa effectively delivers therapeutic oligonucleotide into cells via dectin-1 receptor and attenuates TNFα gene expression.

    abstract：:Grifola frondosa is an edible and medicinal mushroom with great nutritional values and bioactivities. In the present study, a soluble homogeneous β-glucan, GFPS, with high molecular mass of 5.42 × 106 Da was purified from the fruit bodies of Grifola frondosa using 5% cold NaOH. The structure of GFPS was determined wit...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.236

    authors： Cui H,Zhu X,Huo Z,Liao B,Huang J,Wang Z,Song C,Hu X,Fang J

    更新日期：2020-04-15 00:00:00

  • Sorbitol counteracts high hydrostatic pressure-induced denaturation of inulin fructotransferase.

    abstract：:Inulin fructotransferase (IFTase), a novel hydrolase for inulin, was exposed to high hydrostatic pressure (HHP) at 400 and 600 MPa for 15 min in the presence or absence of sorbitol. Sorbitol protected the enzyme against HHP-induced activity loss. The relative residual activity increased nearly 3.1- and 3.8-fold in the...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.06.023

    authors： Li Y,Miao M,Liu M,Jiang B,Zhang T,Chen X

    更新日期：2014-09-01 00:00:00

  • Biodistribution profiling of the chemical modified hyaluronic acid derivatives used for oral delivery system.

    abstract：:A series of adipic acid dihydrazide (ADH)-modified hyaluronic acid (HA-ADH) compounds were synthesized and conjugated with QDots (QDots-HA conjugates) to assess the effects of the molecular weight (MW) and extent of chemical modification of HA on its biodistribution. Their physicochemical structures were confirmed by ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.11.027

    authors： Hsieh CM,Huang YW,Sheu MT,Ho HO

    更新日期：2014-03-01 00:00:00

  • Polysaccharides from loquat (Eriobotrya japonica) leaves: Impacts of extraction methods on their physicochemical characteristics and biological activities.

    abstract：:Impacts of hot water extraction (HWE), pressurized water extraction (PWE), high-speed shearing homogenization extraction, microwave assisted extraction (MAE), ultrasound assisted extraction (UAE), ultrasound assisted enzymatic extraction, and ultrasound-microwave assisted extraction (UMAE) on physicochemical character...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.273

    authors： Fu Y,Li F,Ding Y,Li HY,Xiang XR,Ye Q,Zhang J,Zhao L,Qin W,Gan RY,Wu DT

    更新日期：2020-03-01 00:00:00

  • Interaction of gentamicin sulfate with alginate and consequences on the physico-chemical properties of alginate-containing biofilms.

    abstract：BACKGROUND:Alginate is one of the main extracellular polymeric substances (EPS) in biofilms of Cystic Fibrosis (CF) patients suffering from pulmonary infections. Gentamicin sulfate (GS) can strongly bind to alginate resulting in loss of pharmacological activity; however neither the mechanism nor its repercussion is ful...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.025

    authors： Heriot M,Nottelet B,Garric X,D'Este M,Richards GR,Moriarty FT,Eglin D,Guillaume O

    更新日期：2019-01-01 00:00:00

  • Interactions and compatibility of 11 S globulin from Vicia faba seeds and sodium salt of carboxymethylcellulose in an aqueous medium.

    abstract：:This work studies specific interactions and compatibility between a legumin and a linear carboxylated polysaccharide using gel permeation chromatography, sedimentation analysis, SDS gel electrophoresis, viscometry and phase analysis measurements. It uses the system water/11 S globulin/CMC as a model. Carboxymethylcell...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.12.011

    authors： Antonov YA,Dmitrochenko AP,Leontiev AL

    更新日期：2006-02-28 00:00:00

  • Antioxidant and antibacterial chitosan film with tea polyphenols-mediated green synthesis silver nanoparticle via a novel one-pot method.

    abstract：:In the present study, the antioxidant and antibacterial chitosan/tea polyphenols-silver nanoparticles composite film (CS/TP-AgNPs) was developed via a novel one-pot method. The TP was added to the CS film not only as the reducing agent of AgNPs but also as the cross-linking agent and antioxidant. The AgNPs and nanocom...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.093

    authors： Zhang W,Jiang W

    更新日期：2020-07-15 00:00:00

  • Sodium alginate: An efficient biopolymeric catalyst for green synthesis of 2-amino-4H-pyran derivatives.

    abstract：:Sodium alginate, a naturally occurring macromolecule, in its granular form and without any post-modification was found to be an efficient and recoverable bifunctional heterogeneous organocatalyst for the domino synthesis of various 2-amino-3-cyano-4H-pyran annulated derivatives through three-component condensation of ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.01.080

    authors： Dekamin MG,Peyman SZ,Karimi Z,Javanshir S,Naimi-Jamal MR,Barikani M

    更新日期：2016-06-01 00:00:00

  • Conformation of bovine submaxillary mucin layers on hydrophobic surface as studied by biomolecular probes.

    abstract：:In the present study, the conformational changes of bovine submaxillary mucin (BSM) adsorbed on a hydrophobic surface (polystyrene (PS)) as a function of concentration in bulk solution (up to 2mg/mL) have been investigated with biomolecular probe-based approaches, including bicinchoninic acid (BCA), enzyme-linked immu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.09.035

    authors： Pakkanen KI,Madsen JB,Lee S

    更新日期：2015-01-01 00:00:00

  • Isolation and structural characterization of sulfated polysaccharide from Spirulina platensis and its bioactive potential: In vitro antioxidant, antibacterial activity and Zebrafish growth and reproductive performance.

    abstract：:In this study, the sulfated polysaccharide (SPs) was isolated from Spirulina platensis. The isolated SPs contains carbohydrate, sulfate, protein and uronic acid at 38.7 ± 0.30%, 21.3 ± 0.87%, 7.1 ± 0.15% and 7.9 ± 0.4% respectively. The elemental analysis confirmed the presence of carbon (18.01 ± 0.10%), hydrogen (1.8...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.09.024

    authors： Rajasekar P,Palanisamy S,Anjali R,Vinosha M,Elakkiya M,Marudhupandi T,Tabarsa M,You S,Prabhu NM

    更新日期：2019-12-01 00:00:00

  • Proteome analysis reveals a strong correlation between olfaction and pollen foraging preference in honeybees.

    abstract：:To gain a deeper understanding of the molecular basis of pollen foraging preference, we characterized the proteomes of antennae and brains of bees foraging on pear and rapeseed flowers, and the volatile compounds from nectar, anther, and inflorescence of both plants. Bees foraging on the pollen of the two plants have ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.140

    authors： Guo Y,Fu B,Qin G,Song H,Wu W,Shao Y,Altaye SZ,Yu L

    更新日期：2019-01-01 00:00:00

  • A novel GH16 beta-agarase isolated from a marine bacterium, Microbulbifer sp. BN3 and its characterization and high-level expression in Pichia pastoris.

    abstract：:An agar-degrading bacterium, strain BN3, was isolated from a coastal soil sample collected in Taiwan Strait, China and identified to be a novel species of the genus Microbulbifer. The gene (N3-1) encoding for a novel β-agarase from the isolate was cloned and sequenced. It encoded a mature protein with 274 amino acids ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.08.053

    authors： Li RK,Chen Z,Ying XJ,Ng TB,Ye XY

    更新日期：2018-11-01 00:00:00

  • Arginine-rich hydrophobic polyethylenimine: potent agent with simple components for nucleic acid delivery.

    abstract：:Conjugation of various arginine-rich peptide sequences to vectors based on 10 kDa polyethylenimine (PEI) and its hydrophobic derivative (hexanoate-PEI) was investigated as a strategy for improving pDNA and siRNA transfection activities. Six different arginine-histidine (RH) sequences and two arginine-serine (RS) seque...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.05.001

    authors： Parhiz H,Hashemi M,Hatefi A,Shier WT,Amel Farzad S,Ramezani M

    更新日期：2013-09-01 00:00:00

  • Bio-based Preservative using Methyl-β-cyclodextrin-Essential Oil Complexes for Wood Protection.

    abstract：:Developing natural preservatives for wood protection is of great interest in sustainable construction and green building industries. This study was designed to determine the feasibility of using methyl-β-cyclodextrin-essential oils (MβCD-EOs) complexes as potential bio-based preservatives for wood protection. Four ess...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.056

    authors： Cai L,Lim H,Nicholas DD,Kim Y

    更新日期：2020-03-15 00:00:00

  • Enhancing the thermostability of Rhizopus chinensis lipase by rational design and MD simulations.

    abstract：:To improve the thermostability of r27RCL from Rhizopus chinensis and broaden its industrial applications, we used rational design (FoldX) according to ΔΔG calculation to predict mutations. Four thermostable variants S142A, D217V, Q239F, and S250Y were screened out and then combined together to generate a quadruple-mut...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.243

    authors： Wang R,Wang S,Xu Y,Yu X

    更新日期：2020-10-01 00:00:00

  • Poly (A) binding protein enhances the binding affinity of potyvirus VPg to eukaryotic initiation factor eIF4F and activates in vitro translation.

    abstract：:Viral protein linked to the genome (VPg) of turnip mosaic virus (TuMV) interacts with eIF4F and plays an important role in cap-independent initiation of protein synthesis. In order to understand the importance of PABP on the interaction of eIF4F with VPg, we report that PABP enhanced the binding affinity ~3- and 4-fol...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.135

    authors： Khan MA,Goss DJ

    更新日期：2019-01-01 00:00:00

  • Papain-like cysteine proteinase zone (PCP-zone) and PCP structural catalytic core (PCP-SCC) of enzymes with cysteine proteinase fold.

    abstract：:There are several families of cysteine proteinases with different folds - for example the (chymo)trypsin fold family and papain-like fold family - but in both families the hydrolase activity of cysteine proteinases requires a cysteine residue as the catalytic nucleophile. In this work, we have analyzed the topology of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.10.022

    authors： Denessiouk K,Uversky VN,Permyakov SE,Permyakov EA,Johnson MS,Denesyuk AI

    更新日期：2020-12-15 00:00:00

  • Catalytic phenol removal using entrapped cross-linked laccase aggregates.

    abstract：:Laccase was immobilized using a combinatorial strategy of cross-linking and entrapping in mesoporous silica to prepare entrapped enzyme species including simply adsorbed, entrapped cross-linked enzyme (E-CLE) and entrapped cross-linked enzyme aggregate (E-CLEA) to explore their potential in phenol removal. Parameters ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.10.147

    authors： Fathali Z,Rezaei S,Faramarzi MA,Habibi-Rezaei M

    更新日期：2019-02-01 00:00:00

  • Characterization and antioxidant activities of polysaccharides from thirteen boletus mushrooms.

    abstract：:Water-soluble polysaccharides were extracted from the caps and stipes of thirteen boletus mushrooms representing five different species collected in Southwest China. Investigations of their structures and antioxidant activities allowed an evaluation of structure-function relationships. The polysaccharides were compose...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.02.084

    authors： Zhang L,Hu Y,Duan X,Tang T,Shen Y,Hu B,Liu A,Chen H,Li C,Liu Y

    更新日期：2018-07-01 00:00:00

  • Observation of in vitro cellulose synthesis by bacterial cellulose synthase with time-resolved small angle X-ray scattering.

    abstract：:Cellulose synthase is the enzyme that produces cellulose in the living organisms like plant, and has two functions: polymerizing glucose residues (polymerization) and assembling these polymerized molecules into a crystalline microfibril with a "cellulose I" crystallographic structure (crystallization). Many studies, h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.02.167

    authors： Tajima H,Penttilä PA,Imai T,Yamamoto K,Yuguchi Y

    更新日期：2019-06-01 00:00:00

  • Thermal, mechanical, and physical properties of seaweed/sugar palm fibre reinforced thermoplastic sugar palm Starch/Agar hybrid composites.

    abstract：:The aim of this research is to investigate the effect of sugar palm fibre (SPF) on the mechanical, thermal and physical properties of seaweed/thermoplastic sugar palm starch agar (TPSA) composites. Hybridized seaweed/SPF filler at weight ratio of 25:75, 50:50 and 75:25 were prepared using TPSA as a matrix. Mechanical,...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.079

    authors： Jumaidin R,Sapuan SM,Jawaid M,Ishak MR,Sahari J

    更新日期：2017-04-01 00:00:00

  • Effects of ionic polysaccharides and egg white protein complex formulations on dough rheological properties, structure formation and in vitro starch digestibility of wet sweet potato vermicelli.

    abstract：:Effects of ionic polysaccharides [chitosan (C), sodium alginate (A) and xanthan (X)] and egg white protein (EP) complex formulations on dough rheology, structure formation and in vitro starch digestibility of wet sweet potato vermicelli (SPV) were investigated. Linear viscoelastic region (LVR) with low strain level of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.020

    authors： Feng YY,Mu TH,Zhang M,Ma MM

    更新日期：2020-04-15 00:00:00

  • Removal and separation of Cu(II) from aqueous solutions using nano-silver chitosan/polyacrylamide membranes.

    abstract：:In the present study, adsorption of Cu(II) ions from aqueous solutions was evaluated using new thin adsorptive membranes modified with silver nanoparticles. Membranes were prepared from chitosan/polyacrylamide polymer blend. The variation of adsorption process was investigated in batch sorption mode. Infrared absorpti...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.01.101

    authors： Abou El-Reash YG,Abdelghany AM,Elrazak AA

    更新日期：2016-05-01 00:00:00

  • Temperature and salt optimization of kappa-carrageenan fractionation by DEAE-cellulose.

    abstract：:Carrageenans play an important role in many medical and food technology applications. However, the study of their properties has been hampered by a lack of well-defined samples (fractions). In this paper, a new principle is presented by which well-defined fractions can be obtained. It is based on batch adsorption to D...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(94)90017-5

    authors： Caram-Lelham N,Cleland RL,Sundelöf LO

    更新日期：1994-04-01 00:00:00

  • Antibacterial, antifungal and anticoagulant activities of chicken PLA2 group V expressed in Pichia pastoris.

    abstract：:Secretory class V phospholipase A2 (PLA2-V) has been shown to be involved in inflammatory processes in cellular studies, but the biochemical and physical properties of this important enzyme have been unclear. As a first step towards understanding the structure, function and regulation of this PLA2, we report the expre...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.045

    authors： Karray A,Bou Ali M,Kharrat N,Gargouri Y,Bezzine S

    更新日期：2018-03-01 00:00:00