Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering.

Abstract:

:Bone is a highly integrative and dynamic tissue of the human body. It is continually remodeled by bone cells such as osteoblasts, osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale. Effective therapies for bone defects can be met via bone tissue engineering which employs drug delivery systems with biomaterials to enhance cellular functions by acting on signaling pathways such as Wnt, BMP, TGF-β, and Notch. This review provides the current understanding of polymers/bioceramics/bioactive compounds as scaffolds in activation of signaling pathways for the formation of bone.

journal_name

Int J Biol Macromol

authors

Rao SH,Harini B,Shadamarshan RPK,Balagangadharan K,Selvamurugan N

doi

10.1016/j.ijbiomac.2017.09.029

subject

Has Abstract

pub_date

2018-04-15 00:00:00

pages

88-96

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)32128-1

journal_volume

110

pub_type

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