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Flammulina velutipes polysaccharide improves C57BL/6 mice gut health through regulation of intestine microbial metabolic activity.

Abstract：

:Flammulina velutipes polysaccharides (FVP) can improve gut health through gut microbiota and metabolism regulation. In this study, the 28-days fed experiment was used to investigate gut microbime and metabolic profiling induced by FVP. After treatment, intestinal tissue section showed the higher villus height and villus height/crypt depth (V/C) value in FVP-treated group. The 16 s rRNA gene sequencing revealed microbiota composition alteration caused by FVP, as the Firmicutes phylum increased while Bacteroidetes phylum slightly decreased. The metabolic profiling was detected by LC/MS and results showed 56 and 99 compounds were dramatically changed after FVP treatment in positive and negative ion mode, respectively. Annotation in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways displayed the adjustment of energy metabolism, amino acid metabolism, nucleotide metabolism and other related basic pathways after FVP treatment. Our study suggested that FVP can be developed as a dietary supplement for intestine health promotion.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Hao Y,Wang X,Yuan S,Wang Y,Liao X,Zhong M,He Q,Shen H,Liao W,Shen J

doi

10.1016/j.ijbiomac.2020.11.085

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

1308-1318

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)35010-8

journal_volume

167

pub_type

杂志文章

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