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Phage display antibody libraries: A robust approach for generation of recombinant human monoclonal antibodies.

Abstract：

:Monoclonal antibodies (mAbs) and their derivatives have achieved remarkable success as medicine, targeting both diagnostic and therapeutic applications associated with communicable and non-communicable diseases. In the last 3 to 4 decades, tremendous success has been manifested in the field of cancer therapy, autoimmune diseases, cardiovascular and infectious diseases. MAbs are the fastest growing class of biopharmaceuticals, with more than 25 derivatives are in clinical use and 7 of these have been isolated through phage display technology. Phage display technology has gained impetus in the field of medical and health sciences, as a large repertoire of diverse recombinant antibodies, targeting various antigens have been generated in a short span of time. A prominent number of phage display derived antibodies are already approved for therapy and significant numbers are currently in clinical trials. In this review we have discussed the various strategies employed for generation of monoclonal antibodies; their advantages, limitations and potential therapeutic applications. We also discuss the potential of phage display antibody libraries in isolation of monoclonal antibodies.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Kumar R,Parray HA,Shrivastava T,Sinha S,Luthra K

doi

10.1016/j.ijbiomac.2019.06.006

subject

Has Abstract

pub_date

2019-08-15 00:00:00

pages

907-918

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)33085-5

journal_volume

135

pub_type

杂志文章,评审

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