Abstract:
:In this study, the polysaccharide from Polygonatum sibiricum (PSP) was evaluated for the immunomodulatory activity by the cyclophosphamide (Cy)-induced immunosuppressed-model in vivo. The PSP has been analyzed in order to identify a variety of chemical properties such as monosaccharide compositions and structural confirmation. The results show that the main components of PSP were galactose and rhamnose. The PSP could significantly stimulate neutral red phagocytosis of RAW264.7 macrophages. Compared with the cyclophosphamide group, PSP accelerated recovery of spleen and thymus indexes, and enhanced T cell and B cell proliferation responses as well as peritoneal macrophage phagocytosis. In addition, PSP treatment restored the levels of IL-2, TNF-α, IL-8 and IL-10 in the serum of the Cy-treated mice in a dose-dependent manner. Therefore, PSP played an important role in the protection against immunosuppression in the Cy-treated mice and could be used as a potential immunostimulant agent.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Liu N,Dong Z,Zhu X,Xu H,Zhao Zdoi
10.1016/j.ijbiomac.2017.09.051subject
Has Abstractpub_date
2018-02-01 00:00:00pages
796-802issue
Pt Aeissn
0141-8130issn
1879-0003pii
S0141-8130(16)30994-1journal_volume
107pub_type
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2006.02.020
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2013.06.034
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
doi:10.1016/j.ijbiomac.2020.10.125
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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更新日期:2020-05-03 00:00:00
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
pub_type: 杂志文章
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journal_title:International journal of biological macromolecules
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journal_title:International journal of biological macromolecules
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