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Strategies for screening, purification and characterization of bacteriocins.

Abstract：

:Bacteriocins are bioactive antimicrobial peptides synthesized in the ribosome of numerous bacteria and released extracellularly. Bacteriocins have the ability to kill or inhibit the growth of prokaryotes and could potentially be useful against pathogens and antibiotic-resistant strains of bacteria. The antimicrobial mechanisms and relatively narrow killing spectrums of bacteriocins distinguish them from traditional broad-spectrum antibiotics, making them possible candidates to replace antibiotics in the future. In recent years, researchers have discovered many new bacteriocins from different sources. However, the discovery of new bacteriocins involves complicated screening, identification, purification, and characterization processes. This review describes the strategies currently employed for screening, identification, purification, and characterization of bacteriocins. Approximately 40 novel bacteriocins are reviewed in this paper. Our conclusions about the research process will guide the development of novel methods and allow for the faster, easier, and more efficient discovery of novel bacteriocins.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zou J,Jiang H,Cheng H,Fang J,Huang G

doi

10.1016/j.ijbiomac.2018.05.233

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

781-789

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)31827-0

journal_volume

117

pub_type

杂志文章,评审

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