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Anti-tumor and anti-virus activity of polysaccharides extracted from Sipunculus nudus(SNP) on Hepg2.2.15.

Abstract：

:Many polysaccharides have biological activities and have been investigated for their antitumor effects. In this study, we investigated the anti-tumor activity and anti-virus activity of SNP-the water-soluble polysaccharides extracted from Sipunculus nudus on Hepg2.2.15. Flow cytometry analysis demonstrated that SNP induced dose-dependent cell apoptosis on Hepg2.2.15. Real-time PCR and Western Blot analysis showed that SNP down-regulated the synthesis of HBsAg, HBV-DNA and enhanced the expression of pro-apoptosis proteins TNF-α, caspase-3, and Bax, while decreasing the expression of the anti-apoptosis proteins survivin, Bcl-2, and VEGF. These results suggested that SNP suppressed cell viability of Hepg2.2.15 and that could be a novel anti-tumor and anti-HBV agent.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Su J,Jiang L,Wu J,Liu Z,Wu Y

doi

10.1016/j.ijbiomac.2016.03.022

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

597-602

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30246-X

journal_volume

87

pub_type

杂志文章

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