Development of biodegradable antibacterial cellulose based hydrogel membranes for wound healing.


:Cellulose-based hydrogels have wide applications in tissue engineering and controlled delivery systems. In this study, chloramphenicol (CAP) loaded 2,3 dialdehyde cellulose (DABC) hydrogel membranes were prepared, characterized and their antibacterial efficacy was evaluated. Bacterial cellulose (BC) secreted by Acetobacter xylinum was modified to become DABC by oxidation via the sodium metaperiodate method. CAP-BC and CAP-DABC interactions were illustrated via ATR-FTIR analysis. Water retention capacity of BC and DABC membranes were determined as 65.6±1.6% and 5.3±0.3%, respectively. CAP release profiles were determined via HPLC analysis. The drug-loading capacities of BC and DABC membranes were 5mg/cm(2) and 0.1mg/cm(2), respectively. Membranes released 99-99.5% of the contained CAP within 24h and an initial burst release effect was not observed. In vitro antibacterial tests of BC and DABC, both CAP-loaded, demonstrated their ability to inhibit bacterial growth for a prolonged duration. Antimicrobial effect against bacteria was still prevalent after 3 days of incubation period with disc diffusion tests. The MTT test results reveal that fibroblast adhesion and proliferation on CAP-loaded DABC membranes were noticeably higher than CAP-loaded BC membrane. This newly developed drug containing DABC membranes seem to be highly suitable for wound healing due to its unique properties of biodegradability, biocompatibility, and antimicrobial effectiveness.


Int J Biol Macromol


Laçin NT




Has Abstract


2014-06-01 00:00:00












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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Zia-Ud-Din,Chen L,Ullah I,Wang PK,Javaid AB,Hu C,Zhang M,Ahamd I,Xiong H,Wang Z

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  • Biosynthesis and mobilization of poly(3-hydroxybutyrate) [P(3HB)] by Spirulina platensis.

    abstract::Three strains of Spirulina platensis isolated from different locations showed capability of synthesizing poly(3-hydroxybutyrate) [P(3HB)] under nitrogen-starved conditions with a maximum accumulation of up to 10 wt.% of the cell dry weight (CDW) under mixotrophic culture conditions. Intracellular degradation (mobiliza...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Jau MH,Yew SP,Toh PS,Chong AS,Chu WL,Phang SM,Najimudin N,Sudesh K

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  • Chitosan cross-linked docetaxel loaded EGF receptor targeted nanoparticles for lung cancer cells.

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Maya S,Sarmento B,Lakshmanan VK,Menon D,Seabra V,Jayakumar R

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  • Chitosan coated synergistically engineered nanoemulsion of Ropinirole and nigella oil in the management of Parkinson's disease: Formulation perspective and In vitro and In vivo assessment.

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Nehal N,Nabi B,Rehman S,Pathak A,Iqubal A,Khan SA,Yar MS,Parvez S,Baboota S,Ali J

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    journal_title:International journal of biological macromolecules

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    authors: Jabeen S,Islam A,Ghaffar A,Gull N,Hameed A,Bashir A,Jamil T,Hussain T

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  • Oxidative stress level and dehydrin gene expression pattern differentiate two contrasting cucumber F1 hybrids under high fertigation treatment.

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Oszlányi R,Mirmazloum I,Pónya Z,Szegő A,Jamal S,Bat-Erdene O,Papp I

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    journal_title:International journal of biological macromolecules

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    authors: Pachuau L,Dutta RS,Devi TB,Deka D,Hauzel L

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Mahmud MM,Perveen A,Jahan RA,Matin MA,Wong SY,Li X,Arafat MT

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Youssef AM,Abdel-Aziz MS,El-Sayed SM

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  • Injectable alginate-O-carboxymethyl chitosan/nano fibrin composite hydrogels for adipose tissue engineering.

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Jaikumar D,Sajesh KM,Soumya S,Nimal TR,Chennazhi KP,Nair SV,Jayakumar R

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Borzova VA,Markossian KA,Kurganov BI

    更新日期:2014-07-01 00:00:00

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    journal_title:International journal of biological macromolecules

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    authors: Hong YK,Wu HT,Ma T,Liu WJ,He XJ

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    journal_title:International journal of biological macromolecules

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    authors: Domard A,Gey C,Taravel F

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    journal_title:International journal of biological macromolecules

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    journal_title:International journal of biological macromolecules

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    authors: Phunpee S,Saesoo S,Sramala I,Jarussophon S,Sajomsang W,Puttipipatkhachorn S,Soottitantawat A,Ruktanonchai UR

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    journal_title:International journal of biological macromolecules

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    authors: Adalı T,Uncu M

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    journal_title:International journal of biological macromolecules

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    更新日期:2015-01-01 00:00:00

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    journal_title:International journal of biological macromolecules

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    authors: Rai S,Yadav S,Rai R,Chatterjee A,Singh S,Rai LC

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    journal_title:International journal of biological macromolecules

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    authors: Lee H,Kim HS

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  • A cyclic disulfide peptide reproduces in solution the main structural features of a native antigenic site of foot-and-mouth disease virus.

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    journal_title:International journal of biological macromolecules

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    authors: Haack T,Camarero JA,Roig X,Mateu MG,Domingo E,Andreu D,Giralt E

    更新日期:1997-06-01 00:00:00

  • Microbial-based synthesis of highly elastomeric biodegradable poly(3-hydroxybutyrate-co-4-hydroxybutyrate) thermoplastic.

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    journal_title:International journal of biological macromolecules

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    authors: Huong KH,Teh CH,Amirul AA

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    journal_title:International journal of biological macromolecules

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    authors: Rovoli M,Thireou T,Choiset Y,Haertlé T,Sawyer L,Eliopoulos E,Kontopidis G

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  • Design of anti-BVDV drug based on common chemical features, their interaction, and scaffolds of TLR8 agonists.

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    authors: Chai HH,Lim D,Suk JE,Choi BH,Cho YM

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章,评审


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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Li Q,Wang Q,Jin X,Chen Z,Xiong C,Li P,Zhao J,Huang W

    更新日期:2019-02-01 00:00:00

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Ono Y,Furihata K,Isobe N,Saito T,Isogai A

    更新日期:2018-02-01 00:00:00

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Zhang K,Huang TS,Yan H,Hu X,Ren T

    更新日期:2020-02-15 00:00:00

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    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Lin LL,Chi MC,Lan YJ,Lin MG,Juang TY,Wang TF

    更新日期:2018-10-01 00:00:00

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    abstract::The study of drug-DNA interactions is of great importance, as it paves the way towards the design of better therapeutic agents. Here, the interaction of DNA with a therapeutic and prophylactic drug citral has been studied. We have attempted to ascertain the mode of binding of citral with calf thymus DNA (Ct-DNA) throu...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章


    authors: Alam MF,Varshney S,Khan MA,Laskar AA,Younus H

    更新日期:2018-07-01 00:00:00