Abstract：
:Magnetic nanoparticles coated with polymer shell containing reactive functional groups are of great interest especially as substrates for immobilization of ligands in biomedicine and catalysis. This article describes synthesis of novel functional MNPs coated with aminated starch via simple, fast and efficient method of functionalization of the surface by one-minute pounding in mortar. The concept is based on simplifying the synthesis of the magnetic support and obtaining a material that allows for effective bioligand immobilization. Basing on our previous research in the area of MNPs synthesis and biomedical applications, the high yield (149.96 mg/g of support) and effective immobilization of HSA was demonstrated for these nanoparticles without loss of protein activity. Obtained materials were characterized with ATR-FTIR spectroscopy, scanning (SEM) and transmission (TEM) electron microscopy, dynamic light scattering (DLS), X-ray diffraction, TGA-DTA and SQUID analysis. The developed method allows for modification of polysaccharides and nanoparticles towards materials enriched with amino groups in a quick and easy way. It can be expected that this method of quick solvent-free amination will find application in the chemistry of materials and polymers. In addition, the new obtained amino-rich MNPs may find use as carriers for the immobilization of bioligands in catalysis and pharmaceutical analysis.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Ziegler-Borowska Mdoi
10.1016/j.ijbiomac.2019.06.044subject
Has Abstractpub_date
2019-09-01 00:00:00pages
106-114eissn
0141-8130issn
1879-0003pii
S0141-8130(19)32416-Xjournal_volume
136pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章,评审
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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abstract：:The present research work was designed to develop dorzolamide-loaded chitosan-coated polycaprolactone nanoparticles (DRZ-CS-PCL-NPs) for improved ocular delivery. The nanoparticles were prepared by single-step emulsification technique and optimized using the three-factor three-level Box-Behnken design. The optimized D...
journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2020-11-15 00:00:00
