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Thermal unfolding of human lysozyme induces aggregation: Recognition of the aggregates by antisera against the native protein.

Abstract：

:Protein aggregates are formed due to the inappropriate folding of polypeptides. Human lysozyme (HLZ) plays an important role in the innate immune response of the body and has been used extensively as a model protein to study aggregation. In this study, we showed that HLZ undergoes unfolding induced aggregation when heated by using spectroscopic and microscopic techniques. We further showed that the aggregates were recognized by polyclonal antibodies against the native HLZ. The consequences of these observations are further co-related with mammalian physiology.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Alam MT,Rizvi A,Rauf MA,Owais M,Naeem A

doi

10.1016/j.ijbiomac.2018.02.095

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

976-982

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)30138-7

journal_volume

113

pub_type

杂志文章

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