当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Synthesis, antimicrobial and release of chloroamphenicol loaded poly(L-lactic acid)/ZrO2 nanofibrous membranes.

Synthesis, antimicrobial and release of chloroamphenicol loaded poly(L-lactic acid)/ZrO2 nanofibrous membranes.

Abstract：

:Electrospinning technique was used to fabricate chloroamphenicol loaded poly (L-lactic acid)/ZrO2 (CP-PLLA/ZrO2) nanofibrous membranes. The average diameter of drug carrier PLLA/ZrO2 nanofibers increased with ZrO2 concentration increasing and ribbon-shape fibers were present when ZrO2 content reached 3% and above. The existence of hydrogen and ZrOC bonds between PLLA and ZrO2 units improved the thermal stability of PLLA. The model drug CP loading showed no significant changes on the size and shape of nanofibers when CP content was below 8%, but the fibers were uneven and interspersed with ball-shape beads when CP content rose up to 10%. From the antimicrobial activity and release experimental result, the CP-PLLA/ZrO2 nanofibrous membranes revealed well controlled release and better antimicrobial activity against Staphylococcus aureus, which may have potential as a new nanofibrous membrane in drug delivery and wound dressing.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Wang H,Ma X,Li Y,Jiang S,Zhai L,Jiang S,Li X

doi

10.1016/j.ijbiomac.2013.10.002

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

494-9

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00546-1

journal_volume

62

pub_type

杂志文章

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