当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Injectable angiogenic and osteogenic carrageenan nanocomposite hydrogel for bone tissue engineering.

Injectable angiogenic and osteogenic carrageenan nanocomposite hydrogel for bone tissue engineering.

Abstract：

:Functional biomaterials that couple angiogenesis and osteogenesis processes are vital for bone tissue engineering and bone remodeling. Herein we developed an injectable carrageenan nanocomposite hydrogel incorporated with whitlockite nanoparticles and an angiogenic drug, dimethyloxallylglycine. Synthesized whitlockite nanoparticles and nanocomposite hydrogels were characterized using SEM, TEM, EDS and FTIR. Developed hydrogels were injectable, mechanically stable, cytocompatible and has better protein adsorption. Incorporation of dimethyloxallylglycine resulted in initial burst release followed by sustained release for 7 days. Human umbilical vein endothelial cells exposed to dimethyloxallylglycine incorporated nanocomposite hydrogel showed enhanced cell migration and capillary tube-like structure formation. Osteogenic differentiation in rat adipose derived mesenchymal stem cells after 7 and 14 days revealed increased levels of alkaline phosphatase activity in vitro. Furthermore, cells exposed to nanocomposite hydrogel revealed enhanced protein expressions of RUNX2, COL and OPN. Overall, these results suggest that incorporation of whitlockite and dimethyloxallylglycine in carrageenan hydrogel promoted osteogenesis and angiogenesis in vitro.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yegappan R,Selvaprithiviraj V,Amirthalingam S,Mohandas A,Hwang NS,Jayakumar R

doi

10.1016/j.ijbiomac.2018.10.182

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

320-328

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)34870-0

journal_volume

122

pub_type

杂志文章

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