A polysaccharide isolated from Sphallerocarpus gracilis protects PC12 cells against hydrogen peroxide-induced injury.

Abstract:

:Sphallerocarpus gracilis is a medicinal and edible plant in China with high nutritional value. We examined the structure and bioactivity of a new polysaccharide fraction purified from S. gracilis named SGP-1. This polysaccharide possessed an average molecular weight of 4.916 × 105 and was primarily composed of arabinose, mannose and glucose in a molar ratio of 1.08:94.54:4.38. Atomic force microscopy indicated that SGP-1 adopts a sphere-like chain conformation. Bioactivity tests showed that SGP-1 significantly protected PC12 cells from oxidative injury caused by H2O2 and enhanced superoxide dismutase and glutathione peroxidase activities. Moreover, SGP-1 reduced PC12 apoptosis by inhibiting Caspase-3 and Caspase-9 activities. These results provide a scientific basis for the further use of SGP-1 as a novel functional component in the treatment of oxidative damage-derived diseases.

journal_name

Int J Biol Macromol

authors

Guo J,Liu Q,Wang C,Shi J,Zhang J

doi

10.1016/j.ijbiomac.2018.11.208

subject

Has Abstract

pub_date

2019-05-15 00:00:00

pages

1133-1139

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)34357-X

journal_volume

129

pub_type

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