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Synthetic biology approaches: Towards sustainable exploitation of marine bioactive molecules.

Abstract：

:The discovery of genes responsible for the production of bioactive metabolites via metabolic pathways combined with the advances in synthetic biology tools, has allowed the establishment of numerous microbial cell factories, for instance the yeast cell factories, for the manufacture of highly useful metabolites from renewable biomass. Genome mining and metagenomics are two platforms provide base-line data for reconstruction of genomes and metabolomes which is based in the development of synthetic/semi-synthetic genomes for marine natural products discovery. Engineered biofilms are being innovated on synthetic biology platform using genetic circuits and cell signalling systems as represillators controlling biofilm formation. Recombineering is a process of homologous recombination mediated genetic engineering, includes insertion, deletion or modification of any sequence specifically. Although this discipline considered new to the scientific domain, this field has now developed as promising endeavor on the accomplishment of sustainable exploitation of marine natural products.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Seghal Kiran G,Ramasamy P,Sekar S,Ramu M,Hassan S,Ninawe AS,Selvin J

doi

10.1016/j.ijbiomac.2018.01.149

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

1278-1288

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)34910-3

journal_volume

112

pub_type

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