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Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole.

Abstract：

:In this study, the fluid uptake (swelling) kinetics and disintegrant properties of gellan gum in metronidazole tablets were evaluated in both simulated gastric and intestinal fluids (SGF and SIF respectively) without enzymes. The mechanical properties as well as the disintegration and dissolution profile of the tablets were also assessed and compared with those of two standard disintegrants: maize starch and sodium starch glycolate (Primogel). Results show that, swelling was faster and higher in SIF than SGF with the minimum and maximum swelling rates of the gum being 0.365 and 6.900 mm(3)/min respectively in SGF, while the corresponding values in SIF were 0.277 and 7.600 mm(3)/min respectively. The gum was most effective as a disintegrant for metronidazole tablets at an optimum concentration of 0.2% (w/w) when incorporated extra-granularly.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Emeje MO,Franklin-Ude PI,Ofoefule SI

doi

10.1016/j.ijbiomac.2010.05.005

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

158-63

issue

2

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(10)00159-5

journal_volume

47

pub_type

杂志文章

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