当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Biomaterials based on N,N,N-trimethyl chitosan fibers in wound dressing applications.

Biomaterials based on N,N,N-trimethyl chitosan fibers in wound dressing applications.

Abstract：

:In the present work, N,N,N-trimethyl chitosan (TMC) fibers were synthesized successfully and the resulting quaternized materials were characterized by FTIR. The designed TMC fibers with different degree of quaternization achieved high water absorption capability. In antibacterial activity study, TMC fibers showed high antibacterial activity than chitosan fibers against the gram-negative bacteria Escherichia coli (>63%) and gram-positive bacteria Staphylococcus aureus (>99%). TMC fibers exhibited no obvious cytotoxicity to mouse embryo fibroblast cells with low extraction concentrations (<0.05g/mL). In animal wound healing test, TMC2 fibers could significantly enhance wound re-epithelialization and contraction compared with the control (chitosan fibers). In conclusion, TMC fibers have a potential to be used as wound dressing materials.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zhou Z,Yan D,Cheng X,Kong M,Liu Y,Feng C,Chen X

doi

10.1016/j.ijbiomac.2016.02.036

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

471-6

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30168-4

journal_volume

89

pub_type

杂志文章

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