当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Zinc-chitosan nanoparticles induced apoptosis in human acute T-lymphocyte leukemia through activation of tumor necrosis factor receptor CD95 and apoptosis-related genes.

Zinc-chitosan nanoparticles induced apoptosis in human acute T-lymphocyte leukemia through activation of tumor necrosis factor receptor CD95 and apoptosis-related genes.

Abstract：

:Chitosan (CS), a novel biomaterial is widely used as a drug nano-carrier for cancer treatments. Towards this aim, anticancer and antibacterial activities of CS-nanoparticles-linked zinc (Zn-CSNPs) were evaluated. The particle size of CSNPs was lowered (113.09 nm) compared to Zn-CSNPs (160.7 nm). Both nanoparticles (CSNPs and Zn-CSNPs) were spherical in shape, polydispersive and homogenous. Fourier transforms infrared spectrophotometer (FTIR) and energy dispersive X-ray spectroscopy (EDX) analysis confirmed the different molecular arrangement of NPs and the presence of Zn in Zn-CSNPs and CS in both NPs, respectively. Zn-CSNPs had higher inhibitory activity against tested pathogens with a minimal inhibitory concentration (MIC) of 9.25-13.5 μg·mL-1 and showed the complete inhibition of Staphylococcus aureus and Escherichia coli. Zn-CSNPs have triggered the apoptosis through activation of first apoptosis signal receptor/cluster of differentiation 95 (Fas/CD95), and apoptotic-regulatory genes and caused 65-70% of cellular damage in human acute T-lymphocyte leukemia (6T-CEM) cells. Overall, internalizing properties of Zn from CSNPs is a promising therapeutic approach to treat Zn-deficiency related diseases particularly human acute leukemia (HAL).

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Saravanakumar K,Jeevithan E,Chelliah R,Kathiresan K,Wen-Hui W,Oh DH,Wang MH

doi

10.1016/j.ijbiomac.2018.08.017

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

1144-1153

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)33355-5

journal_volume

119

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Refolding of urea denatured ovalbumin with three phase partitioning generates many conformational variants.

    abstract：:Three phase partitioning is a process in which mixing t-butanol with ammonium sulphate with a protein solution leads to the formation of three phases. Generally, the interfacial protein precipitate (formed between upper t-butanol rich and lower aqueous phase) can be easily dissolved back in aqueous buffers. In case of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.06.008

    authors： Rather GM,Gupta MN

    更新日期：2013-09-01 00:00:00

  • Preparation of low digestible and viscoelastic tigernut (Cyperus esculentus) starch by Bacillus acidopullulyticus pullulanase.

    abstract：:Tigernut starch is an underutilized food resource. In this study, pullulanase (PUL) hydrolysis was used to change its physiochemical properties for different food applications. The content of low digestible fractions, resistant starch and slow digestible starch, in PUL modified tigernut starch significantly increased ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.04.068

    authors： Li X,Fu J,Wang Y,Ma F,Li D

    更新日期：2017-09-01 00:00:00

  • Classification of hydrocolloids based on in vitro starch digestibility and rheological properties of Segoami gel.

    abstract：:The influence of hydrocolloids on in vitro starch digestibility and rheological properties of Segoami (a new rice variety fortified with amylose and dietary fiber) gel was investigated in terms of type (sodium alginate, arabic gum, guar gum, locust bean gum, and xanthan gum) and addition levels (0.3-0.7% for rice flou...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.063

    authors： Jung DS,Bae IY,Oh IK,Han SI,Lee SJ,Lee HG

    更新日期：2017-11-01 00:00:00

  • Material properties and cell compatibility of poly(γ-glutamic acid)-keratin hydrogels.

    abstract：:Given the great demand for biopolymer and protein-based products from renewable resources, synthesis of a keratin-based hydrogel is presented herein. In this work, a novel hydrogel of poly(γ-glutamic acid) (γ-PGA) and keratin was synthesized through facile EDC·HCl/HOBt chemistry. Since keratin main chain is rich in am...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.020

    authors： Bajestani MI,Kader S,Monavarian M,Mousavi SM,Jabbari E,Jafari A

    更新日期：2020-01-01 00:00:00

  • Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds.

    abstract：:α-chitin hydrogel/nano hydroxyapatite (nHAp) composite scaffold have been synthesized by freeze-drying approach with nHAp and α-chitin hydrogel. The prepared nHAp and nanocomposite scaffolds were characterized using DLS, SEM, FT-IR, XRD and TGA studies. The porosity, swelling, degradation, protein adsorption and biomi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.03.006

    authors： Kumar PT,Srinivasan S,Lakshmanan VK,Tamura H,Nair SV,Jayakumar R

    更新日期：2011-07-01 00:00:00

  • Study on the derivation of cassava residue and its application in surface sizing.

    abstract：:In order to maximize value and minimize waste, carboxymethyl cellulose (CMC) and carboxymethyl starch (CMS) was synthesized via solvent method using cassava residue as raw material. The alkalization time, etherification temperature, the amounts of reactants and the alkali boiling pretreatment which influence the carbo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.01.115

    authors： Yun T,Pang B,Lu J,Lv Y,Cheng Y,Wang H

    更新日期：2019-05-01 00:00:00

  • Characterization of low-cost glycolipoprotein biosurfactant produced by Lactobacillus plantarum 60 FHE isolated from cheese samples using food wastes through response surface methodology and its potential as antimicrobial, antiviral, and anticancer activi

    abstract：:Considering the need of new lactic acid bacteria (LAB) for the production of novel biosurfactant (BS) molecules, the current study brings out a new insight on the exploration of cheese samples for BS producers and process optimization for industrial applications. In view of this, Lactobacillus plantarum 60FHE, Lactoba...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.140

    authors： Sakr EAE,Ahmed HAE,Abo Saif FAA

    更新日期：2021-02-15 00:00:00

  • Molecular aspects on the specific interaction of cytotoxic plant alkaloid palmatine to poly(A).

    abstract：:The interaction of the protoberberine alkaloid palmatine with single and double stranded structures of poly(A) was studied by various biophysical techniques. Comparative binding studies were also performed with double stranded DNA, t-RNA, poly(C).poly(G), poly(U) and poly(C). The results of competition dialysis, fluor...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2006.03.026

    authors： Giri P,Hossain M,Kumar GS

    更新日期：2006-11-15 00:00:00

  • Unfolding pathways of human serum albumin: evidence for sequential unfolding and folding of its three domains.

    abstract：:Human serum albumin (HSA) contains three alpha-helical domains (I-III). The unfolding process of these domains was monitored using covalently bound fluorescence probes; domain I was monitored by N-(1-pyrene)maleimide (PM) conjugated with cys-34, domain II was monitored by the lone tryptophan residue and domain III was...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2005.10.009

    authors： Santra MK,Banerjee A,Rahaman O,Panda D

    更新日期：2005-12-15 00:00:00

  • Purification, physicochemical properties, and statistical optimization of fibrinolytic enzymes especially from fermented foods: A comprehensive review.

    abstract：:Fibrinolytic enzymes are proteases responsible for cleavage of fibrin mesh in thrombus clots, which are the primary causative agents in cardiovascular diseases. Developing safe, effective and cheap thrombolytic agents are important for prevention and cure of thrombosis. Although a wide variety of sources have been dis...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.07.303

    authors： Moula Ali AM,Bavisetty SCB

    更新日期：2020-11-15 00:00:00

  • Some physico-chemical properties of Prunus armeniaca L. gum exudates.

    abstract：:The objectives of this paper were to investigate some physicochemical properties of Prunus armeniaca L. gum exudates (PAGE). PAGE had, on average, 66.89% carbohydrate, 10.47% uronic acids, 6.9% moisture (w.b.), 2.91% protein, 4% ash and 1.59% fat. PAGE was composed of monosaccharides including l-arabinose, d-galactose...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.09.068

    authors： Fathi M,Mohebbi M,Koocheki A

    更新日期：2016-01-01 00:00:00

  • Biodeuteration of poly(beta-hydroxybutyrate).

    abstract：:The formation of poly(beta-hydroxybutyrate), PHB, by Rhodobacter sphaeroides and Alcaligenes eutrophus was studied using the following carbon sources and solvents: (1), acetate in H2O; (2), D3-acetate in H2O; (3), acetate in 90 to 92% D2O; and (4), D3-acetate in 90 to 92% D2O. The growth of Rb. sphaeroides cultured un...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(05)80017-0

    authors： Gross RA,Ulmer HW,Lenz RW,Tshudy DJ,Uden PC,Brandt H,Fuller RC

    更新日期：1992-02-01 00:00:00

  • Furan-modified natural rubber: A substrate for its reversible crosslinking and for clicking it onto nanocellulose.

    abstract：:The conventional vulcanization process applied to elastomers is irreversible and hinders therefore their useful recycling. We demonstrate here that natural rubber can be reversibly crosslinked via the Diels-Alder coupling of furan and maleimide moieties. The furan-modified natural rubber used in this strategy was also...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.11.102

    authors： Trovatti E,Cunha AG,Carvalho AJ,Gandini A

    更新日期：2017-02-01 00:00:00

  • Gene expression studies and molecular characterization of a cathepsin L-like from the Asian citrus psyllid Diaphorina citri, vector of Huanglongbing.

    abstract：:Huanglongbing (HLB) is a devastating citrus disease associated with Candidatus Liberibacter asiaticus (CLas) and is transmitted by the psyllid Diaphorina citri Kuwayama. Diaphorina citri belongs to Hemiptera order, which has cysteine peptidases as the most abundant proteolytic enzymes present in digestive tract. As cy...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.070

    authors： Ferrara TFS,Schneider VK,Lima PS,Bronze FS,Machado MFM,Henrique-Silva F,Soares-Costa A,Carmona AK

    更新日期：2020-04-30 00:00:00

  • Physical properties imparted by genipin to chitosan for tissue regeneration with human stem cells: A review.

    abstract：:Genipin is a fully assessed non-cytotoxic crosslinking compound. The chitosan|genipin physical properties such as morphology, roughness, porosity, hydrophilicity, ζ-potential, surface area and surface energy exert control over cell adhesion, migration, phenotype maintenance and intracellular signaling in vitro, and ce...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2016.03.075

    authors： Muzzarelli RA,El Mehtedi M,Bottegoni C,Gigante A

    更新日期：2016-12-01 00:00:00

  • Physicochemical and functional characterization of mannan exopolysaccharide from Weissella confusa MD1 with bioactivities.

    abstract：:The present study focused on production, optimization and characterization of exopolysaccharide (EPS) from Weissella confusa MD1. The purified EPS MD1 was also evaluated for in vitro biological activities. The maximum yield of EPS (10.07 ± 0.32 g/L) was obtained with optimized culture conditions of 35 °C at pH 6.5 for...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.09.139

    authors： Lakra AK,Domdi L,Tilwani YM,Arul V

    更新日期：2020-01-15 00:00:00

  • Molecular modification of native coffee polysaccharide using subcritical water treatment: Structural characterization, antioxidant, and DNA protecting activities.

    abstract：:Polysaccharides are an abundant resource in coffee beans and have proved to show numerous bioactivities. Despite their abundance, their activities are not always satisfactory mostly due to their structure and large molecular size. Molecular modifications of native polysaccharides can overcome this problem. In this stu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.03.034

    authors： Getachew AT,Chun BS

    更新日期：2017-06-01 00:00:00

  • High resolution neutron fibre diffraction data on hydrogenated and deuterated cellulose.

    abstract：:High-resolution fibre neutron diffraction data were recorded from cellulose samples on a D19 diffractometer at the Institut Laue-Langevin (Grenoble). Highly crystalline cellulose I samples from Cladophora (cellulose I alpha + I beta) or Halocynthia (cellulose I beta) origin were prepared in the form of oriented films....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(99)00094-x

    authors： Nishiyama Y,Okano T,Langan P,Chanzy H

    更新日期：1999-12-01 00:00:00

  • Effect of diameter of poly(lactic acid) fiber on the physical properties of poly(ɛ-caprolactone).

    abstract：:Biodegradable polymer composites based on poly(ɛ-caprolactone) (PCL) and poly(lactic acid) (PLA) fibers with diameters of 18, 26, 180 μm were prepared by melt compounding. The PLA fiber content in the composites was constant at 20% by weight. The effects of fibers with different diameters on the physical properties an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.01.059

    authors： Ju D,Han L,Guo Z,Bian J,Li F,Chen S,Dong L

    更新日期：2015-05-01 00:00:00

  • Injectable self-healing carboxymethyl chitosan-zinc supramolecular hydrogels and their antibacterial activity.

    abstract：:Injectable and self-healing hydrogels have found numerous applications in drug delivery, tissue engineering and 3D cell culture. Herein, we report an injectable self-healing carboxymethyl chitosan (CMCh) supramolecular hydrogels cross-linked by zinc ions (Zn2+). Supramolecular hydrogels were obtained by simple additio...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.04.025

    authors： Wahid F,Zhou YN,Wang HS,Wan T,Zhong C,Chu LQ

    更新日期：2018-07-15 00:00:00

  • An investigation on biosorption of nitrate from water by chitosan based organic-inorganic hybrid biocomposites.

    abstract：:In this study, three types of crosslinked organic-inorganic hybrid biocomposites, such as chitosan/bentonite, chitosan/titanium oxide, and chitosan/alumina (ChBT, ChTi, and ChAl respectively) were prepared and utilized for the removal of nitrate from water by batch biosorption experiments. Effects of crosslinker dose,...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.066

    authors： Golie WM,Upadhyayula S

    更新日期：2017-04-01 00:00:00

  • Molecular mechanisms associated with macrophage activation by Rhizoma Atractylodis Macrocephalae polysaccharides.

    abstract：:The present study was to elucidate the mechanisms underlying macrophage activation by total polysaccharides from Rhizoma Atractylodis Macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted productions of NO, ROS, cytokines and chemokines, enhanced pinocytic and phagocytic activity, and upregulat...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.081

    authors： Xu W,Fang S,Wang Y,Zhang T,Hu S

    更新日期：2020-03-15 00:00:00

  • Fabrication of pure chitosan nanofibrous membranes as effective absorbent for dye removal.

    abstract：:The pure chitosan nanofibrous membranes with average fiber diameter of 86±18, 114±17,164±28nm were successfully prepared by electrospinning. Batch adsorption experiments of using chitosan nanofibrous membranes as adsorbent to remove acid blue-113 were conducted. The adsorption capacity of 1377mg/g was achieved by the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.072

    authors： Li C,Lou T,Yan X,Long YZ,Cui G,Wang X

    更新日期：2018-01-01 00:00:00

  • Interaction of hexa-His tag with acidic amino acids results in facilitated refolding of halophilic nucleoside diphosphate kinase.

    abstract：:We have previously reported that amino-terminal extension sequence containing hexa-His facilitated refolding and assembly of hexameric nucleoside diphosphate kinase from extremely halophilic archaeon Halobacterium salinarum (NDK). In this study, we made various mutations in both the tag sequence and within NDK molecul...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.07.014

    authors： Ishibashi M,Ida K,Tatsuda S,Arakawa T,Tokunaga M

    更新日期：2011-11-01 00:00:00

  • Preparation and characterization of bacterial cellulose produced from fruit and vegetable peels by Komagataeibacter hansenii GA2016.

    abstract：:This study focused on the investigation of bacterial cellulose production potency of some fruit and vegetable peels (cucumber, melon, kiwifruit, tomato, apple, quince and pomegranate) with Komagataeibacter hansenii GA2016. Fruit and vegetable peels were hydrolyzed, used for bacterial cellulose (BC) production and thei...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.049

    authors： Güzel M,Akpınar Ö

    更新日期：2020-11-01 00:00:00

  • Biomaterials based on N,N,N-trimethyl chitosan fibers in wound dressing applications.

    abstract：:In the present work, N,N,N-trimethyl chitosan (TMC) fibers were synthesized successfully and the resulting quaternized materials were characterized by FTIR. The designed TMC fibers with different degree of quaternization achieved high water absorption capability. In antibacterial activity study, TMC fibers showed high...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.02.036

    authors： Zhou Z,Yan D,Cheng X,Kong M,Liu Y,Feng C,Chen X

    更新日期：2016-08-01 00:00:00

  • Influence of drying of chara cellulose on length/length distribution of microfibrils after acid hydrolysis.

    abstract：:Chara is a genus of freshwater alga that is evolutionarily observed at the aquatic-terrestrial boundary, whose cellulose microfibrils are similar to those of terrestrial plants regarding the crystallinity and biosynthesis of cellulose. Oven-dried and never-dried celluloses samples were prepared from chara. Terrestrial...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.051

    authors： Horikawa Y,Shimizu M,Saito T,Isogai A,Imai T,Sugiyama J

    更新日期：2018-04-01 00:00:00

  • Isolation, characterization and bioactivities of the polysaccharides from Dicliptera chinensis (L.) Juss.

    abstract：:The polysaccharides of Dicliptera chinensis (L.) Juss. (DCP-1 and DCP-2) were extracted and isolated using the methods of water extract-ethanol precipitate and sephadex column chromatography and characterized by gel permeation chromatography (GPC), Fourier transform infrared spectrometry (FT-IR) and gas chromatography...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.03.112

    authors： Xu Y,Gao Y,Zhong M,Li J,Cao H,Huang S,Wei R,Zhang K

    更新日期：2017-08-01 00:00:00

  • Inhibition of tyrosinase by fumaric acid: Integration of inhibition kinetics with computational docking simulations.

    abstract：:Fumaric acid (FA), which is naturally found in organisms, is a well known intermediate of the citric acid cycle. We evaluated the effects of FA on tyrosinase activity and structure via enzyme kinetics and computational simulations. FA was found to be a reversible inhibitor of tyrosinase and its induced mechanism was t...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.013

    authors： Gou L,Lee J,Yang JM,Park YD,Zhou HM,Zhan Y,Lü ZR

    更新日期：2017-12-01 00:00:00

  • Novel tacrine/acridine anticholinesterase inhibitors with piperazine and thiourea linkers.

    abstract：:A new series of substituted tacrine/acridine and tacrine/tacrine dimers with aliphatic or alkylene-thiourea linkers was synthesized and the potential of these compounds as novel human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE) inhibitors with nanomolar inhibition activity was evaluated. The m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.06.064

    authors： Hamulakova S,Imrich J,Janovec L,Kristian P,Danihel I,Holas O,Pohanka M,Böhm S,Kozurkova M,Kuca K

    更新日期：2014-09-01 00:00:00