Abstract：
:The present study was to elucidate the mechanisms underlying macrophage activation by total polysaccharides from Rhizoma Atractylodis Macrocephalae (RAMPtp). The results showed that RAMPtp significantly promoted productions of NO, ROS, cytokines and chemokines, enhanced pinocytic and phagocytic activity, and upregulated expressions of accessory and costimulatory molecules. RNA-seq analysis presented 2868 DEGs and 737 GO terms. PPI network analysis in combination with KEGG pathways as well as the western blot and functional verification assays indicated that NF-κB and STATs were the key regulators modulating the expressions of core gene TNF-α and IL-6 individually, and the transposition activation of NF-κB was identified as an early event in macrophage activation induced by RAMPtp. The involvements of MAPKs and PI3K-Akt pathways were also determined. These results indicated that immune response and immune function were regulated in RAMPtp-stimulated macrophages via a complex interaction network, in which NF-κB and Jak-STAT signaling pathways played a pivotal role.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Xu W,Fang S,Wang Y,Zhang T,Hu Sdoi
10.1016/j.ijbiomac.2020.01.081subject
Has Abstractpub_date
2020-03-15 00:00:00pages
616-628eissn
0141-8130issn
1879-0003pii
S0141-8130(19)40125-6journal_volume
147pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
pub_type： 杂志文章
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更新日期：2019-07-15 00:00:00
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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