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Heparin based polyurethanes: A state-of-the-art review.

Abstract：

:Polyurethanes (PUs) are considered currently as one of the established bio compatible and blood compatible biomaterials offering tremendous structure-property relationship. But few limitations such as low resistance to micro-emboli and thrombi are still associated with these biomaterials that restricted their applications and hence need to be modified. Heparin, a highly sulfonated and negatively charged member of glycosaminoglycan family is well established for their anti-thrombin, anticoagulant and many biological activities that make it a highly attractive candidate capable of modifying or tailoring polymer properties. Incorporation of heparin for the improvement of biocompatibility of PUs is an interesting approach and enabling emerging technology. This review focuses on the methods used for modification of PUs via heparin with their pros and cons. The major PU-heparin systems with the recent developments and their possible biomedical applications are discussed.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Zia F,Zia KM,Zuber M,Tabasum S,Rehman S

doi

10.1016/j.ijbiomac.2015.12.004

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

101-11

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)30190-2

journal_volume

84

pub_type

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