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Physical properties imparted by genipin to chitosan for tissue regeneration with human stem cells: A review.

Abstract：

:Genipin is a fully assessed non-cytotoxic crosslinking compound. The chitosan|genipin physical properties such as morphology, roughness, porosity, hydrophilicity, ζ-potential, surface area and surface energy exert control over cell adhesion, migration, phenotype maintenance and intracellular signaling in vitro, and cell recruitment at the tissue-scaffold interface in vivo. For example a therapy using fucose|chitosan|genipin nanoparticles encapsulating amoxicillin, based on the recognition of fucose by H. pylori, leads to sharply improved clinical results. A bioactive scaffold sensitive to environmental stimuli provides an alternative approach for inducing adipose stem cell chondrogenesis: the expression of specific genes, the accumulation of cartilage-related macromolecules and the mechanical properties are comparable to the original cartilage-derived matrix (CDM), thus making the CDM|genipin a contraction-free biomaterial suitable for cartilage tissue engineering. For the regeneration of the cartilage, chitosan|genipin permits to modulate matrix synthesis and proliferation of chondrocytes by dynamic compression; chondrocytes cultured on the composite substrate produce much more collagen-II and sulfated GAG. The main advantages gained in the bone regeneration area with chitosan|genipin are: acceleration of mineral deposition; enhancement of adhesion, proliferation and differentiation of osteoblasts; promotion of the expression of osteogenic differentiation markers; greatly improved viability of human adipose stem cells.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Muzzarelli RA,El Mehtedi M,Bottegoni C,Gigante A

doi

10.1016/j.ijbiomac.2016.03.075

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1366-1381

issue

Pt B

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30234-3

journal_volume

93

pub_type

杂志文章,评审

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