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Probing the structure-function relationship of Mycobacterium leprae HSP18 under different UV radiations.

Abstract：

:Ultraviolet radiation, an effective sterilizing source, rapidly kills the causative organism (Mycobacterium leprae) of leprosy. But, the reasons behind this quick death are not clearly understood. Also, the impact of UV radiation on the antigen(s) which is/are responsible for the survival of this pathogen is still unknown. Many reports have revealed that M. leprae secrets a major immunodominant antigen, namely HSP18, whose chaperone function plays an important role in the growth and survival of this pathogen under various environmental insults. However, the effect of UV radiation on its structure and chaperone function is still unclear. Therefore, we have taken a thorough attempt to understand these two aspects of HSP18 under different UV radiations (UVA/UVB/UVC; doses: 1-50 J/cm2). Our study revealed that its chaperone function is decreased significantly with increasing doses of various UV radiations. These different UV irradiations perturb only its tertiary structure and induce tryptophan and tyrosine photo-oxidation to N-formyl kynurenine, kynurenine and dityrosine. Such photo-oxidation promotes the subunit cross-linking within a HSP18 oligomer, lowers the surface hydrophobicity and thermostability of the protein. All these factors together damage/reduce the chaperone function of HSP18 which may be an important factor behind the rapid death of M. leprae under UV exposure.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Chakraborty A,Nandi SK,Panda AK,Mahapatra PP,Giri S,Biswas A

doi

10.1016/j.ijbiomac.2018.07.151

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

604-616

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)31395-3

journal_volume

119

pub_type

杂志文章

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