Optimization, characterization and evaluation of chitosan-tailored cubic nanoparticles of clotrimazole.

Abstract:

:The present study deals with improvement of the mucoadhesive properties of monoolein based cubic nanoparticles by incorporating chitosan. Chitosan-tailored cubic nanoparticles were prepared by thin film hydration followed by ultrasonication employing clotrimazole as model drug. The effect of Pluronic F127 fraction and concentration of chitosan on particle size and % mucin binding of the formulations was studied using 2-factor, 3-level, central composite experimental design. The concentration of chitosan was found to influence particle size and % mucin binding of cubic nanoparticles while Pluronic F127 fraction influenced only the % mucin binding. Studies indicated 8.33(%w/w) fraction of Pluronic F127 and 0.17 (%w/v) concentration of chitosan as optimum concentration. Finally, the optimized batch was characterized by polarized light microscopy, small-angle X-ray scattering (SAXS) and transmission electron microscopy. The results unveiled incorporation of chitosan did not disrupt the inner cubic structure of nanoparticles. Peak indexing of SAXS data revealed the coexistence of P-type and D-type cubic phases in nanoparticles. Further, comparative evaluation studies showed significantly higher anti-fungal activity of clotrimazole-loaded chitosan-tailored cubic nanoparticles than conventional suspension of clotrimazole against Candida albicans.

journal_name

Int J Biol Macromol

authors

Verma P,Ahuja M

doi

10.1016/j.ijbiomac.2014.10.065

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

138-45

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(14)00750-8

journal_volume

73

pub_type

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