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Aronia melanocarpa as a protector against nitration of fibrinogen.

Abstract：

:Fibrinogen (Fg) also known as coagulation factor I represents about 4% of the total human plasma proteins. The main function of Fg is its involvement in last phase of blood coagulation cascade, when thrombin-induced conversion of dissolved plasma fibrinogen into an insoluble fibrin clot occurs. The reaction of fibrinogen with peroxynitrite causes both structural modifications and changes of the biological properties of this plasma glycoprotein. Recently, there is an increased interest in the screening of natural products present in fruits, vegetables and herbs for their possible antioxidative activities. Therefore, the aim of our study was to estimate the effect of extract from berries of Aronia melanocarpa against nitrative and oxidative damage induced by peroxynitrite. The extract from A. melanocarpa (0.5-50 μg/ml) added to Fg 10 min before peroxynitrite (100 μM) significantly inhibited both the formation of the high molecular weight protein aggregates and nitration of Fg molecule. The extract also abolished peroxynitrite-induced inhibition of fibrinogen polymerization (by 95% at 50 μg/ml). The obtained results indicate that natural extract from berries of A. melanocarpa has protective effects against peroxynitrite-induced nitrative damage of plasma fibrinogen, and therefore may contribute in the prevention of peroxynitrite-related cardiovascular or inflammatory diseases.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Bijak M,Saluk J,Antosik A,Ponczek MB,Żbikowska HM,Borowiecka M,Nowak P

doi

10.1016/j.ijbiomac.2013.01.019

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

264-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00026-3

journal_volume

55

pub_type

杂志文章

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