Abstract：
:Reduced graphene oxide (RGO) has shown tremendous potential as a NIR responsive nanomaterial and has been extensively explored for NIR mediated photothermal therapy and drug delivery. However, the potential of NIR as a stimulus to trigger release of entrapped/complexed DNA from its surface have not been explored. Strong complexation between the loaded cargo and the carrier often leads to no-release or decrease in the release of the therapeutic cargo. Herein, we investigated NIR as a stimulus for inducing DNA release from RGO nanocomposites. A quaternary ammonium modified poly(allylamine hydrochloride) functionalized RGO nanocomposite (RGO-MPAH) was synthesized, which was further tagged with a targeting moiety, folic acid (FA). The structural, optical and chemical properties of the synthesized nanocomposites were characterized which validated successful reduction and functionalization of GO with PAH/MPAH. The nanocomposites were found to be non-toxic and showed excellent DNA binding ability at complexation ratios as low as 3:1 (w/w). Additionally, the nanocomposites demonstrated NIR responsive release of complexed DNA from their surfaces, with RGO-PAH showing maximum DNA release followed by RGO-MPAH and RGO-MPAH-FA. This study shows the potential of NIR light to act as a stimulus for inducing release of entrapped nucleic acids from the surface of nanocarriers.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Roy S,Jaiswal Adoi
10.1016/j.ijbiomac.2020.02.216subject
Has Abstractpub_date
2020-06-15 00:00:00pages
931-941eissn
0141-8130issn
1879-0003pii
S0141-8130(19)40583-7journal_volume
153pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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