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Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.

Abstract：

:An algal extracellular biopolymer (over 8.5 × 10(5)Da) composed of carbohydrates (52%) and protein (∼13%) has been isolated from a red alga Rhodella grisea growing in natural conditions by concentration of water medium, alcohol precipitation, dialysis and freeze-drying. This mucilagineous biopolymer contained xylose and its 3-O- and 4-O-methyl derivatives (∼63%), galactose (∼12%), glucuronic acid (11-12%), glucose (∼5%), rhamnose (∼4%), fucose (∼3-4%) and low content of others accompaning sugars. When tested on the citric acid-induced cough and reactivity of airways smooth muscle in vivo in the test system guinea pigs, this biopolymer assigned a significant cough suppressing effect. The reactivity of airways smooth muscle was not affected indicating that expectoration effect was not suppressed by biopolymer application, which is important from the pharmacological point of view.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Nosáľová G,Capek P,Flešková D,Jureček L,Hindák F,Lukavský J,Cepák V,Ray B,Breierová E,Turjan J

doi

10.1016/j.ijbiomac.2011.08.029

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1046-50

issue

5

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(11)00344-8

journal_volume

49

pub_type

杂志文章

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