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Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer.

Abstract：

:5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLGA) nanoparticles [NPs] (C-5-FU PLGA NPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1-302.2nm with polydispersity index (PDI) of <0.30. C-coated NPs converted zeta potential from negative to positive value with small modification in particle size distribution. The entrapment efficiency of 5-FU was recorded in the range of 32-51%. The in vitro release studies showed an initial rapid 5-FU release followed by a sustained release profile. The in vitro cytotoxicity of C-5-FU PLGA NPs showed significant inhibition of colon cancer cells (HT-29) compared to the other NPs and drug solution. These results showed that C-5-FU PLGA NPs can be considered as a promising carrier for cancer therapy.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Badran MM,Mady MM,Ghannam MM,Shakeel F

doi

10.1016/j.ijbiomac.2016.11.098

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

643-649

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32242-5

journal_volume

95

pub_type

杂志文章

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