Optimization of brain targeted chitosan nanoparticles of Rivastigmine for improved efficacy and safety.

Abstract:

:The study aims at formulation and optimization brain targeted nanoparticles (NP) of Rivastigmine (RT) to improve its therapeutic potential and to verify its safety profile. The NP were optimized using a two factor three level (3(2)) central composite design aiming to minimize particle size; maximize zeta potential and drug entrapment efficiency of NP. The optimized formulation (cRTNP) was evaluated using in vitro drug release study; in vivo behavioral, and biochemical and maximum tolerated dose (MTD) study. The optimized formulation evidenced a significant reversal of scopolamine-induced amnesia by Tween 80(®) coated nanoparticles as compared to both pure RT as well as uncoated nanoparticles. The MTD of RT was increased by 10% by formulating them as cRTNP. Thus, formulation of RT as cRTNP improved the therapeutic and safety profile of RT.

journal_name

Int J Biol Macromol

authors

Nagpal K,Singh SK,Mishra DN

doi

10.1016/j.ijbiomac.2013.04.024

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

72-83

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(13)00195-5

journal_volume

59

pub_type

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