当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression.

Silencing of IL-6 and STAT3 by siRNA loaded hyaluronate-N,N,N-trimethyl chitosan nanoparticles potently reduces cancer cell progression.

Abstract：

:The immunosuppressive nature of the tumor microenvironment is a critical problem that should be considered before the design of immunotherapies. Interleukin (IL)-6 and its related downstream molecules such as signal transducer and activator of transcription (STAT)3 play an important role in the cancer progression, which can be considered as potential therapeutic targets. In the present study, we generated the active-targeted hyaluronate (HA) recoated N, N, N-trimethyl chitosan (TMC) nanoparticles (NPs) to deliver IL-6- and STAT3-specific small interfering RNAs (siRNAs) to the CD44-expressing cancer cells. We utilized the interaction between HA and CD44 to increase the specificity and efficacy of cellular uptake in NPs. The results showed that the synthesized NPs had efficient physicochemical characteristics, high transfection efficiency, low toxicity, and controlled siRNA release. siRNA-loaded NPs significantly inhibited the IL-6/STAT3 expression, which was associated with blockade of proliferation, colony formation, migration, and angiogenesis in cancer cells. These findings imply the potential of HA-TMC NPs as potent vectors in gene therapy and their application for the silencing of IL-6 and STAT3, as a novel anti-cancer combination therapeutic strategy, for the first time.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Masjedi A,Ahmadi A,Atyabi F,Farhadi S,Irandoust M,Khazaei-Poul Y,Ghasemi Chaleshtari M,Edalati Fathabad M,Baghaei M,Haghnavaz N,Baradaran B,Hojjat-Farsangi M,Ghalamfarsa G,Sabz G,Hasanzadeh S,Jadidi-Niaragh F

doi

10.1016/j.ijbiomac.2020.01.273

subject

Has Abstract

pub_date

2020-04-15 00:00:00

pages

487-500

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)37803-1

journal_volume

149

pub_type

杂志文章

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