Inner membrane complex 1l protein of Plasmodium falciparum links membrane lipids with cytoskeletal element 'actin' and its associated motor 'myosin'.

Abstract:

:The inner membrane complex (IMC) is a defining feature of apicomplexans comprising of lipid and protein components involved in gliding motility and host cell invasion. Motility of Plasmodium parasites is accomplished by an actin and myosin based glideosome machinery situated between the parasite plasma membrane (PPM) and IMC. Here, we have studied in vivo expression and localization of a Plasmodium falciparum (Pf) IMC protein 'PfIMC1l' and characterized it functionally by using biochemical assays. We have identified cytoskeletal protein 'actin' and motor protein 'myosin' as novel binding partners of PfIMC1l, alongside its interaction with the lipids 'cholesterol' and 'phosphatidyl-inositol 4, 5 bisphosphate' (PIP2). While actin and myosin compete for interaction with PfIMC1l, actin and either of the lipids (cholesterol or PIP2) simultaneously bind PfIMC1l. Interestingly, PfIMC1l showed enhanced binding with actin in the presence of calcium ions, and displayed direct binding with calcium. Based on our in silico analysis and experimental data showing PfIMC1l-actin/myosin and PfIMC1l-lipid interactions, we propose that this protein may anchor the IMC membrane with the parasite gliding apparatus. Considering its binding with key proteins involved in motility viz. myosin and actin (with calcium dependence), we suggest that PfIMC1l may have a role in the locomotion of Plasmodium.

journal_name

Int J Biol Macromol

authors

Kumar V,Behl A,Kapoor P,Nayak B,Singh G,Singh AP,Mishra S,Kang TS,Mishra PC,Hora R

doi

10.1016/j.ijbiomac.2018.12.239

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

673-684

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)34592-6

journal_volume

126

pub_type

杂志文章
  • Rheological and controlled release properties of hydrogels based on mushroom hyperbranched polysaccharide and xanthan gum.

    abstract::A hyperbranched polysaccharide, coded as TM3a, was extracted from the Pleurotus tuber-regium sclerotia. TM3a was hybridized with xanthan gum (XG) by chemical crosslinking using sodium trimetaphosphate (STMP) to obtain new hydrogels with self-healing and release-controlled properties. The oscillatory rheological measur...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.09.008

    authors: Zhang R,Tao Y,Xu W,Xiao S,Du S,Zhou Y,Hasan A

    更新日期:2018-12-01 00:00:00

  • On the relationship between the conserved 'black' and 'gray' structural clusters and intrinsic disorder in parvalbumins.

    abstract::Recently we found two highly conserved structural motifs in the members of the EF-hand protein family, which provide a supporting scaffold for their Ca2+ binding loops. Each structural motif is formed by a cluster of three amino acids. These clusters were called 'black' cluster (cluster I) and 'gray' cluster (cluster ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.08.183

    authors: Deryusheva EI,Denesyuk AI,Denessiouk K,Uversky VN,Permyakov SE,Permyakov EA

    更新日期:2018-12-01 00:00:00

  • Molecular weight and antitumour activity of Zymomonas mobilis levans.

    abstract::Levans produced by several Zymomonas mobilis strains were classified by their viscosity average molecular weight and tested against sarcoma 180. Measurements of the samples' polydispersity were carried out to characterise the molecular weight distribution. The antitumour activities of levan samples were plotted agains...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/s0141-8130(00)00125-2

    authors: Calazans GMT,Lima RC,de França FP,Lopes CE

    更新日期:2000-07-12 00:00:00

  • Production and characterization of hydrophilic and hydrophobic sunflower protein isolate nanofibers by electrospinning method.

    abstract::In the present study, sunflower protein isolate (SPI) was extracted and applied for production of nanofiber using polyvinyl alcohol (PVA) in different SPI:PVA volume ratios (0:100, 20:80, 40:60, 60:40, 80:20 and 100:0) under two voltages (18 and 23 kV) and two flow rates (0.5 and 0.75 ml/h). Nanofibers with average di...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.07.132

    authors: Shanesazzadeh E,Kadivar M,Fathi M

    更新日期:2018-11-01 00:00:00

  • Synthesis, characterization and cytocompatibility studies of α-chitin hydrogel/nano hydroxyapatite composite scaffolds.

    abstract::α-chitin hydrogel/nano hydroxyapatite (nHAp) composite scaffold have been synthesized by freeze-drying approach with nHAp and α-chitin hydrogel. The prepared nHAp and nanocomposite scaffolds were characterized using DLS, SEM, FT-IR, XRD and TGA studies. The porosity, swelling, degradation, protein adsorption and biomi...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2011.03.006

    authors: Kumar PT,Srinivasan S,Lakshmanan VK,Tamura H,Nair SV,Jayakumar R

    更新日期:2011-07-01 00:00:00

  • Formulation of extended release cefpodoxime proxetil chitosan-alginate beads using quality by design approach.

    abstract::The purpose of this work was to develop and characterize chitosan-alginate beads for the extended delivery of cefpodoxime proxetil (CFP), to understand the impact of formulation and process parameters on the critical quality attributes (CQAs) using a quality-by-design approach. For this, a study was performed with var...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.05.066

    authors: Mujtaba A,Ali M,Kohli K

    更新日期:2014-08-01 00:00:00

  • Injectable pullulan hydrogel for the prevention of postoperative tissue adhesion.

    abstract::Methods for reducing and preventing postoperative abdominal adhesions have been researched for decades; however, despite these efforts, the formation of postoperative peritoneal adhesions is continuously reported. Adhesions cause serious complications such as postoperative pain, intestinal obstruction, and infertility...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.02.026

    authors: Bang S,Lee E,Ko YG,Kim WI,Kwon OH

    更新日期:2016-06-01 00:00:00

  • Physicochemical and drug release characteristics of acetylated starches of five Lagenaria siceraria cultivars.

    abstract::Modified starches play a crucial role in the pharmaceutical industries in controlling the drug release at a pre-determined rate. The effect of acetylation on the physicochemical and drug release characteristics of the starches from five different Indian L. siceraria cultivars was investigated. Starches isolated from t...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.10.007

    authors: Kulkarni SD,Sinha BN,Kumar KJ

    更新日期:2015-01-01 00:00:00

  • Effect of hyaluronic acid molecular weight on the morphology of quantum dot-hyaluronic acid conjugates.

    abstract::The morphological analysis of novel quantum dot-hyaluronic acid (QDot-HA) conjugates was carried out with a transmission electron microscope (TEM). Adipic acid dihydrazide-modified HA (HA-ADH) was synthesized and conjugated to quantum dots (QDots) having carboxyl terminal ligands which were activated with 1-ethyl-3-(3...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2007.09.002

    authors: Kim J,Park K,Hahn SK

    更新日期:2008-01-01 00:00:00

  • Effects of electron beam irradiation on the properties of waxy maize starch and its films.

    abstract::Waxy maize starch was irradiated under different doses of radiation (2-30 kGy), and starch physicochemical properties were analysed. Films were subsequently produced from native and irradiated waxy maize starches and their properties were tested. The starch molecular weight markedly decreased with increasing irradiati...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.01.287

    authors: Zhou X,Ye X,He J,Wang R,Jin Z

    更新日期:2020-05-15 00:00:00

  • Conformation of bovine submaxillary mucin layers on hydrophobic surface as studied by biomolecular probes.

    abstract::In the present study, the conformational changes of bovine submaxillary mucin (BSM) adsorbed on a hydrophobic surface (polystyrene (PS)) as a function of concentration in bulk solution (up to 2mg/mL) have been investigated with biomolecular probe-based approaches, including bicinchoninic acid (BCA), enzyme-linked immu...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2014.09.035

    authors: Pakkanen KI,Madsen JB,Lee S

    更新日期:2015-01-01 00:00:00

  • Chitosan-alginate immobilized lipase based catalytic constructs: Development, characterization and potential applications.

    abstract::In this study, lipase (LIP) was isolated from Aspergillus crevinus, statistically optimized and purified via ammonium sulfate fractionation (ASF), and Sephadex G-100 gel permeation chromatography. LIP was 2.26-folds purified with a specific activity of 223.60 U/mg. The molecular mass was estimated to be 60 kDa on sodi...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.07.192

    authors: Rashid R,Anwar Z,Zafar M,Rashid T,Butt I

    更新日期:2018-11-01 00:00:00

  • Laccase immobilization on the tailored cellulose-based Granocel carriers.

    abstract::Extracellular laccase produced by Cerrena unicolor was immobilized by adsorption or covalent bonds formation on the cellulose-based carrier Granocel. Immobilization was optimized by changing the anchor groups and the methods of activation/immobilization. On the base of measured activity and stability of immobilized pr...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2007.09.014

    authors: Rekuć A,Kruczkiewicz P,Jastrzembska B,Liesiene J,Peczyńska-Czoch W,Bryjak J

    更新日期:2008-03-01 00:00:00

  • Gene expression studies and molecular characterization of a cathepsin L-like from the Asian citrus psyllid Diaphorina citri, vector of Huanglongbing.

    abstract::Huanglongbing (HLB) is a devastating citrus disease associated with Candidatus Liberibacter asiaticus (CLas) and is transmitted by the psyllid Diaphorina citri Kuwayama. Diaphorina citri belongs to Hemiptera order, which has cysteine peptidases as the most abundant proteolytic enzymes present in digestive tract. As cy...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.04.070

    authors: Ferrara TFS,Schneider VK,Lima PS,Bronze FS,Machado MFM,Henrique-Silva F,Soares-Costa A,Carmona AK

    更新日期:2020-04-30 00:00:00

  • Alginate bionanocomposite films containing sepiolite modified with polyphenols from myrtle berries extract.

    abstract::Alginate nanocomposite films incorporating sepiolite (Sep) modified with myrtle berries extract (MBE) rich in polyphenols were prepared by solution casting method. The effects of different extract concentrations on the film properties were determined by measuring physicochemical, mechanical and antioxidant properties ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.10.052

    authors: Cheikh D,Martín-Sampedro R,Majdoub H,Darder M

    更新日期:2020-12-15 00:00:00

  • Antiplatelet and antithrombotic activity of a fibrin(ogen)olytic protease from Bacillus cereus strain FF01.

    abstract::Fibrin(ogen)olytic enzymes offer great promise for the treatment of thrombosis associated disorders. The present study describes the characterization of an extracellular fibrin(ogen)olytic serine protease (named Bacethrombase) purified from the Bacillus cereus strain FF01. The molecular mass of the Bacethrombase was d...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2015.04.075

    authors: Majumdar S,Dutta S,Das T,Chattopadhyay P,Mukherjee AK

    更新日期:2015-08-01 00:00:00

  • Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications.

    abstract::Injectable thermo-responsive hydrogels have been studied for various biomedical applications including; drug delivery, cell encapsulation, and tissue repairing. There are various natural and synthetic polymers which exhibit homogenous injectable solution at ambient temperature and form a gel in human body temperature....

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijbiomac.2019.04.131

    authors: Darge HF,Andrgie AT,Tsai HC,Lai JY

    更新日期:2019-07-15 00:00:00

  • Pectin-microfibrillated cellulose microgel: Effects on survival of lactic acid bacteria in a simulated gastrointestinal tract.

    abstract::Using high pressure microfluidization, we prepared micro-fibrillated soybean cellulose (MFSC) and analyzed its morphology and structure. MFSC was then incorporated into low-methoxyl pectin (PC) to coat lactic acid bacteria (LAB) by ionotropic gelation, and the effects of PC-MFSC microgel on LAB survival in a simulated...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.04.161

    authors: Chen B,Lin X,Lin X,Li W,Zheng B,He Z

    更新日期:2020-05-06 00:00:00

  • A highly xyloglucan active lytic polysaccharide monooxygenase EpLPMO9A from Eupenicillium parvum 4-14 shows boosting effect on hydrolysis of complex lignocellulosic substrates.

    abstract::The recently identified lytic polysaccharide monooxygenases (LPMOs) are important auxiliary proteins which contribute to lignocellulose biodegradation by oxidatively cleaving the glycosidic bonds in cellulose and other polysaccharides. The vast differences in terms of substrate specificity and regioselectivity within ...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.11.177

    authors: Shi Y,Chen K,Long L,Ding S

    更新日期:2021-01-15 00:00:00

  • Glucose-sensitive delivery of metronidazole by using a photo-crosslinked chitosan hydrogel film to inhibit Porphyromonas gingivalis proliferation.

    abstract::A novel glucose-sensitive drug delivery system with controlled release of metronidazole was synthesized by using biocompatible photo-crosslinked chitosan hydrogel film. Specifically, methacrylic anhydride, as photosensitive substance, was firstly grafted on chitosan molecular chains and then UV irradiation was applied...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2018.09.202

    authors: Liu J,Xiao Y,Wang X,Huang L,Chen Y,Bao C

    更新日期:2019-02-01 00:00:00

  • Hydrodynamic properties of gelatin in dilute solutions.

    abstract::Aggregation properties of Gelatin chains in neutral aqueous solutions, are reported in the temperature range T = 35-60 degrees C, from the measured intrinsic viscosity [eta], diffusion coefficient, D(o), molecular weight Mw, and radius of gyration (Rg) data. Gelatin chains doubled their size as the solution was cooled...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/s0141-8130(98)00003-8

    authors: Bohidar HB

    更新日期:1998-07-01 00:00:00

  • Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols.

    abstract::We have studied the inhibitory effect of five polyphenols namely, resveratrol, piceatannol, quercetin, quercetrin, and quercetin-3-beta-D glucoside on Escherichia coli ATP synthase. Recently published X-ray crystal structures of bovine mitochondrial ATP synthase inhibited by resveratrol, piceatannol, and quercetin, su...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2009.04.004

    authors: Dadi PK,Ahmad M,Ahmad Z

    更新日期:2009-07-01 00:00:00

  • Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris.

    abstract::A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris). The EPS-III was a homogeneous polysaccharide with Mw of 1.56 × 103 kDa. The yield of EPS-III from culture broth was 123.2 ± 3.1 mg/L and the sugar content was 93.32 ± 0.87%. The backbone of EPS-III was ma...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.10.207

    authors: Sun H,Yu X,Li T,Zhu Z

    更新日期:2021-01-01 00:00:00

  • Heteronuclear nuclear magnetic resonance assignments, structure and dynamics of SUMO-1, a human ubiquitin-like protein.

    abstract::The structure of a ubiquitin-like protein, small ubiquitin-related modifier-1 (SUMO-1), was earlier determined using homonuclear nuclear magnetic resonance (NMR) spectroscopy, since the spectral quality of the protein was not suitable for heteronuclear NMR data collection. In this study, a slightly different construct...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/s0141-8130(00)00169-0

    authors: Jin C,Shiyanova T,Shen Z,Liao X

    更新日期:2001-03-14 00:00:00

  • Comparison of two starch-based flocculants with polyacrylamide for the simultaneous removal of phosphorus and turbidity from simulated and actual wastewater samples in combination with FeCl3.

    abstract::Two laboratory-made cationic starch-based flocculants (St-CTA and St-AD) with different chain architectures were used to simultaneously remove phosphorus and turbidity from two simulated wastewaters and one actual wastewater with laboratory and pilot scales, respectively, in conjunction with FeCl3. A commercial polyac...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.11.176

    authors: Hu P,Ren J,Hu X,Yang H

    更新日期:2021-01-15 00:00:00

  • Various applications of immobilized glucose oxidase and polyphenol oxidase in a conducting polymer matrix.

    abstract::In this study, glucose oxidase and polyphenol oxidase were immobilized in conducting polymer matrices; polypyrrole and poly(N-(4-(3-thienyl methylene)-oxycarbonyl phenyl) maleimide-co-pyrrole) via electrochemical method. Fourier transform infrared and scanning electron microscope were employed to characterize the copo...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2006.12.005

    authors: Cil M,Böyükbayram AE,Kiralp S,Toppare L,Yağci Y

    更新日期:2007-06-01 00:00:00

  • Hydroxyapatite-decorated ZrO2 for α-amylase immobilization: Toward the enhancement of enzyme stability and reusability.

    abstract::Herein, the immobilization of α-amylase onto hydroxyapatite (HA) and hydroxyapatite-decorated ZrO2 (10%wt) (HA-ZrO2) nanocomposite were investigated. The immobilization yield was 69.7% and 84% respectively. The structural differences were characterized using X-Ray diffraction, attenuated total reflectance-Fourier tran...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2020.11.150

    authors: Almulaiky YQ,Khalil NM,El-Shishtawy RM,Altalhi T,Algamal Y,Aldhahri M,Al-Harbi SA,Allehyani ES,Bilal M,Mohammed MM

    更新日期:2021-01-15 00:00:00

  • Effect of solution plasma process with bubbling gas on physicochemical properties of chitosan.

    abstract::In the present work, solution plasma process (SPP) with bubbling gas was used to prepare oligochitosan. The effect of SPP irradiation with bubbling gas on the degradation of chitosan was evaluated by the intrinsic viscosity reduction rate and the degradation kinetic. The formation of OH radical was studied. Changes of...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2017.01.049

    authors: Ma F,Li P,Zhang B,Zhao X,Fu Q,Wang Z,Gu C

    更新日期:2017-05-01 00:00:00

  • Kinetics for Cu(2+) induced Sepia pharaonis arginine kinase inactivation and aggregation.

    abstract::Arginine kinase plays an important role in cellular energy metabolism and is closely related to the environmental stress response in marine invertebrates. We studied the Cu(2+)-mediated inhibition and aggregation of Sepia pharaonis arginine kinase (SPAK) and found that Cu(2+) markedly inhibited the SPAK activity along...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.06.049

    authors: Shi XY,Zhang LL,Wu F,Fu YY,Yin SJ,Si YX,Park YD

    更新日期:2016-10-01 00:00:00

  • Silk fibroin as a non-thrombogenic biomaterial.

    abstract::Silk fibroin (SF), is a very attractive protein-polymer, being processed into a variety of formats to match structural and morphological features for specific biomedical applications. The aim of the present work is to investigate blood compatibility of two forms, films and scaffolds, of silk fibroin-N,N' methylene bis...

    journal_title:International journal of biological macromolecules

    pub_type: 杂志文章

    doi:10.1016/j.ijbiomac.2016.01.088

    authors: Adalı T,Uncu M

    更新日期:2016-09-01 00:00:00