Abstract：
:Marine polysaccharide-based nanomaterial attracted considerable attention due to its biocompatibility and biodegradability. Here, a novel polymannuronic acid derivative (PM-C18) was synthesized as nanocarrier modified with hydrophobic oleyl amine. Its structure was confirmed by Fourier-transformed infrared spectrometry and nuclear magnetic resonance. To investigate its function, we developed tacrolimus (FK506) loaded nanoparticle by self-assembling PM-C18 and studied its drug loading, cytotoxicity and mechanism of in vitro release. Furthermore, we established a mouse model of allergic conjunctivitis (AC) to evaluate the efficacy of FK506 loaded PM-C18. The results indicated that PM-C18 carrier can encapsule FK506 with high drug loading (18%) and average particle size of 110.34±1.6nm. The release mechanism was diffusion initially followed a lasting release induced by swelling and collapse of PM-C18. One-week treatment with FK506 loaded PM-C18 efficiently relieved the symptoms of AC, which indicated it could serve as a potential ophthalmic drug for patients with AC. Compared with FK506 ophthalmic suspension, FK506 loaded PM-C18 improved medication adherence. Most importantly, we developed a novel versatile nanomaterial of PM-C18 which could encapsule other active agents for more applications.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Cong M,Wu Z,Xu X,Yin J,Li H,Zhuang B,Wang C,Zhao Xdoi
10.1016/j.ijbiomac.2017.06.064subject
Has Abstractpub_date
2017-11-01 00:00:00pages
862-873issue
Pt Aeissn
0141-8130issn
1879-0003pii
S0141-8130(16)32053-0journal_volume
104pub_type
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journal_title：International journal of biological macromolecules
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journal_title：International journal of biological macromolecules
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