当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice.

Polysaccharide from Spirulina platensis ameliorates diphenoxylate-induced constipation symptoms in mice.

Abstract：

:The aim of this study is to probe new functions of a polysaccharide from Spirulina platensis (PSP) on constipation and intestinal microbiota in mice. Diphenoxylate-induced constipation in mice was treated with different doses of PSP, followed by examining the defecation patterns, levels of acetyl cholinesterase (AchE), nitric oxide (NO), and tissue section histopathology. The composition of intestinal microbiota was determined by genome sequencing analysis of the 16S rDNA. This study found that the average molecular weight of PSP was 29, 600 Da, and mainly monosaccharides of PSP were rhamnose (24.7%), glucose (16.15%) and galactose (13.32%). The beneficial effects of PSP treatment include defecation improvement, increase of AchE activity, reduction of NO concentration, renovation of the damaged intestinal villus and affection on the expression of some related genes in the constipated mice. In addition, PSP had significant effects on the gut microbiota, showing the enhancement in abundance of beneficial bacteria including Akkermansia, Lactobacillus, Butyricimonas, Candidatus Arthromitus and Prevotella, and the reduction in abundance of harmful bacteria such as Clostridium and Dorea. The present s uncovered a new function of PSP, indicating that PSP could be used in constipation therapies.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ma H,Xiong H,Zhu X,Ji C,Xue J,Li R,Ge B,Cui H

doi

10.1016/j.ijbiomac.2019.04.209

subject

Has Abstract

pub_date

2019-07-15 00:00:00

pages

1090-1101

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(19)31660-5

journal_volume

133

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Thermal unfolding of apo- and holo-enolase from Saccharomyces cerevisiae: different mechanisms, similar activation enthalpies.

    abstract：:Yeast enolase is stabilized by its natural cofactor Mg(2+). This stabilization is ascribed to the reduced subunit dissociation of the holoprotein. Nevertheless, how Mg(2+) alters the unfolding mechanism has yet to be fully characterized. Here, we investigate the role of Mg(2+) in the denaturation mechanism and unfoldi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.07.021

    authors： Moreno-Vargas LM,Carrillo-Ibarra N,Arzeta-Pino L,Benítez-Cardoza CG

    更新日期：2011-12-01 00:00:00

  • Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: preparation and characterization.

    abstract：:Porous scaffolds composed of alginate (AG) and chitosan (CS) were fabricated by combining the formation of polyelectrolyte complex (PEC) with freeze-drying. The AG scaffold was used as a framework with uniformly distributed and interconnected pore structure. The chitosan or chitosan/hydroxyapatite (CS/HA) composite so...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.11.004

    authors： Han J,Zhou Z,Yin R,Yang D,Nie J

    更新日期：2010-03-01 00:00:00

  • Evaluation of the thermomechanical properties and biodegradation of brown rice starch-based chitosan biodegradable composite films.

    abstract：:Biodegradable films composed of starch and chitosan plasticized by palm oil were fabricated via a solvent casting technique. In this study, the influence of the ratio of brown rice starch and chitosan on the mechanical, thermal, antimicrobial, and morphological properties of the films was investigated. Antimicrobial f...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.039

    authors： Hasan M,Gopakumar DA,Olaiya NG,Zarlaida F,Alfian A,Aprinasari C,Alfatah T,Rizal S,Khalil HPSA

    更新日期：2020-08-01 00:00:00

  • Inhibition of methemoglobin formation in aqueous solutions under aerobic conditions by the addition of amino acids.

    abstract：:Hemoglobin (Hb) as an important iron-containing oxygen-transport protein is easily oxidized to the ferric met-form, methemoglobin (metHb), and loses the capacity of binding oxygen during storage. In this study, the experimental data indicate that the presence of Tyr and Glu significantly suppress the metHb formation i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.12.010

    authors： Wei Y,Li C,Zhang L,Su Z,Xu X

    更新日期：2014-03-01 00:00:00

  • Bicistronic DNA vaccine macromolecule complexed with poly lactic-co-glycolic acid-chitosan nanoparticles enhanced the mucosal immunity of Labeo rohita against Edwardsiella tarda infection.

    abstract：:DNA vaccine is an important tool to elicit both humoral and cellular immunity. Present study investigates mucosal immune response of Labeo rohita (15 ± 04 g) to plasmid DNA (pDNA) vaccine macromolecule complexed with nanoparticles (NPs). Poly lactic-co-glycolic acid (PLGA), Chitosan (Chit) and PLGA-Chit-NPs were synth...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.048

    authors： Leya T,Ahmad I,Sharma R,Tripathi G,Kurcheti PP,Rajendran KV,Bedekar MK

    更新日期：2020-08-01 00:00:00

  • Penicillin degradation catalysed by Zn(II) ions in methanol.

    abstract：:The rates of degradation, catalysed by Zn(2+), of four classical penicillins-amoxicillin, ampicillin and penicillins G and V-were followed at 20 degrees C in methanol by spectrophotometric assays. Kinetic schemes of the reactions of degradation catalysed by Zn(2+) ions were analogous to those given previously for the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(03)00081-3

    authors： Navarro PG,Blázquez IH,Osso BQ,Martínez de las Parras PJ,Puentedura MI,García AA

    更新日期：2003-12-01 00:00:00

  • Exopolysaccharides production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12: Optimization of fermentation variables and characterization of structure and bioactivities.

    abstract：:In this study, the most important variables (incubation temperature, fermentation time and yeast extract concentration) responsible for the exopolysaccharides (EPSs) production by Lactobacillus acidophilus LA5 and Bifidobacterium animalis subsp. lactis BB12 were screened. The EPSs synthesize by LA5, BB12, and their co...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.084

    authors： Amiri S,Rezaei Mokarram R,Sowti Khiabani M,Rezazadeh Bari M,Alizadeh Khaledabad M

    更新日期：2019-02-15 00:00:00

  • Glucose-sensitivity of liposomes incorporating conjugates of glucose oxidase and poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecylacrylate).

    abstract：:Liposomes, which release their contents in response to the concentration of glucose, were prepared by modifying the liposomal surface with the conjugate of poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecylacrylate) (P(NIPAM-co-MAA-co-ODA)) and glucose oxidase (GOD). The maximum enzymatic activity of copolyme...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.06.008

    authors： Jo SM,Lee HY,Kim JC

    更新日期：2009-11-01 00:00:00

  • A rapid, accurate and sensitive method for determination of monosaccharides in different varieties of Osmanthus fragrans Lour by pre-column derivatization with HPLC-MS/MS.

    abstract：:A specific HPLC-MS/MS (High-Performance Liquid Chromatography with tandem Mass Spectrometry) method was developed and validated for simultaneous determination of several monosaccharides in three kinds Osmanthus fragrans Lour. After extraction, separation, protein removal, pigment removal and hydrolysis, monosaccharide...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.033

    authors： Fan B,Li T,Song X,Wu C,Qian C

    更新日期：2019-03-15 00:00:00

  • Prohibitin as an oxidative stress biomarker in the eye.

    abstract：:Identification of biomarker proteins in the retina and retinal pigment epithelium (RPE) under oxidative stress may imply new insights into signaling mechanisms of retinal degeneration at the molecular level. Proteomic data from an in vivo mice model in constant light and an in vitro oxidative stress model are compared...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.08.018

    authors： Lee H,Arnouk H,Sripathi S,Chen P,Zhang R,Bartoli M,Hunt RC,Hrushesky WJ,Chung H,Lee SH,Jahng WJ

    更新日期：2010-12-01 00:00:00

  • Formation of protein sub-visible particles during vacuum degassing of etanercept solutions.

    abstract：:The main purpose of this manuscript is to describe a phenomenon in which vacuum degassing a reconstituted freeze-dried fusion protein etanercept formulation caused a significant amount of protein sub-visible particles (SbVP). Physical stability of etanercept was monitored by micro-flow imaging (MFI), dynamic light sca...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.02.001

    authors： Wang H,Zheng HJ,Wang Z,Bai H,Carpenter JF,Chen S,Fang WJ

    更新日期：2014-05-01 00:00:00

  • New composites based on starch/Ecoflex®/biomass wastes: Mechanical, thermal, morphological and antimicrobial properties.

    abstract：:Different biomass wastes were successfully blended with starch and Ecoflex® viz. poly(butylene adipate-co-terephthalate), without glycerol addition, to obtain biocomposite materials. The mechanical properties, as well as thermal and surface properties, of the developed composites were evaluated. It was found that the ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.185

    authors： Spiridon I,Anghel NC,Darie-Nita RN,Iwańczuk A,Ursu RG,Spiridon IA

    更新日期：2020-08-01 00:00:00

  • Protein-reduced gold nanoparticles mixed with gentamicin sulfate and loaded into konjac/gelatin sponge heal wounds and kill drug-resistant bacteria.

    abstract：:Timely antibacterial treatment of wounds reduces the probability of wound infection and promotes wound healing. However, the materials used to treat wounds often fail to provide both sterilization (especially for super bacteria) and moisture, and some may even cause secondary injury to the wound. In this study, gold n...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.190

    authors： Zou Y,Xie R,Hu E,Qian P,Lu B,Lan G,Lu F

    更新日期：2020-04-01 00:00:00

  • Insight into the role of integrated carbohydrate polymers (starch, chitosan, and β-cyclodextrin) with mesoporous silica as carriers for ibuprofen drug; equilibrium and pharmacokinetic properties.

    abstract：:Three types of carbohydrate polymers starch (ST), chitosan (CH), and β-cyclodextrin (β-CD) were integrated with mesoporous silica (MCM-48) in some biopolymers nanocomposites (MCM-48/ST, MCM-48/CH, MCM-48/β-CD) as promising delivery systems for ibuprofen drug. This was conducted by simple mixing of the polymers gels wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.052

    authors： Abukhadra MR,Refay NM,Nadeem A,El-Sherbeeny AM,Ibrahim KE

    更新日期：2020-08-01 00:00:00

  • Fractionation and characterization of lignins from Miscanthus via organosolv and soda pulping for biorefinery applications.

    abstract：:The structural complexity of lignins necessitates characterization and isolation methodologies for assessing their appropriateness for thermo-chemical systems and material applications. Lignins prepared via two pulping methods (organosolv and soda) were comprehensively investigated by analyzing the properties, includi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.229

    authors： Kim GH,Um BH

    更新日期：2020-04-29 00:00:00

  • Self-healing, sensitive and antifreezing biomass nanocomposite hydrogels based on hydroxypropyl guar gum and application in flexible sensors.

    abstract：:In this manuscript, self-healing, highly flexible hydrogels based on hydroxypropyl guar gum (HPG) were prepared by adding dopamine-coated reduced-graphene oxide (rGO@PDA). The multiple reversible dynamic networks were simultaneously constructed by boron-oxygen and metal-ligand interactions. These multiple networks sig...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.134

    authors： Sun Z,Wang L,Jiang X,Bai L,Wang W,Chen H,Yang L,Yang H,Wei D

    更新日期：2020-07-15 00:00:00

  • Role of cis-cis muconic acid in the catalysis of Pseudomonas putida chlorocatechol 1,2-dioxygenase.

    abstract：:Chlorocatechol 1,2-dioxygenase (1,2-CCD) is a non-heme iron protein involved in the intradiol cleavage of aromatic compounds that are recalcitrant to biodegradation. In particular, 1,2-CCD catalyzes the conversion of catechol and its halogenated derivatives to cis-cis muconic acid. In this study we describe a series o...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2010.04.016

    authors： Melo FA,Araújo AP,Costa-Filho AJ

    更新日期：2010-08-01 00:00:00

  • The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound.

    abstract：:The aim of this study was to develop a new bioactive gelatin-oxidized starch nanofibers containing Lawsonia Inermis (henna) for treating second-degree burn wounds. Continuous, smooth, and bead-free fibers were obtained when the gelatin-starch ratio was 70/30.Additionally, the fiber dimeter was reduced with increasing ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.061

    authors： Hadisi Z,Nourmohammadi J,Nassiri SM

    更新日期：2018-02-01 00:00:00

  • Effects of tea polyphenols and gluten addition on in vitro wheat starch digestion properties.

    abstract：:Starch-containing food normally has complex components and structure, which control its digestion kinetic properties and nutritional value. However, interactions among multiple food components and their effects on starch digestion kinetics are rarely reported. Here, we evaluated the influence of tea polyphenols [i.e.,...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.224

    authors： Xie F,Huang Q,Fang F,Chen S,Wang Z,Wang K,Fu X,Zhang B

    更新日期：2019-04-01 00:00:00

  • Potent inhibitions of monoamine oxidase A and B by acacetin and its 7-O-(6-O-malonylglucoside) derivative from Agastache rugosa.

    abstract：:Five compounds were isolated from the leaves of Agastache rugosa and tested for monoamine oxidase (MAO) inhibitory activity. Acacetin, a flavonoid, potently inhibited recombinant human MAO-A and MAO-B (IC50=0.19 and 0.17μM, respectively), and reversibly and competitively inhibited MAO-A and MAO-B (Ki=0.045 and 0.037μM...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.076

    authors： Lee HW,Ryu HW,Baek SC,Kang MG,Park D,Han HY,An JH,Oh SR,Kim H

    更新日期：2017-11-01 00:00:00

  • Extraction and characterization of gelatin from the feet of Pekin duck (Anas platyrhynchos domestica) as affected by acid, alkaline, and enzyme pretreatment.

    abstract：:The effects of different pretreatments on yield and composition of extraction, physicochemical, and rheological properties of duck feet gelatin (DFG) were investigated. Gelatins were extracted from the whole feet of Pekin duck with an average yield of 4.09%, 3.65%, and 5.75% for acidic (Ac-DFG), alkaline (Al-DFG), and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.139

    authors： Abedinia A,Ariffin F,Huda N,Nafchi AM

    更新日期：2017-05-01 00:00:00

  • Comparative study of performances of lipase immobilized asymmetric polysulfone and polyether sulfone membranes in olive oil hydrolysis.

    abstract：:In the present study, lipase was immobilized via glutaraldehyde crosslinking on the polysulfone and polyether sulfone asymmetric membranes. The results indicated that the overall immobilization of lipase is related to the hydrophobicity of the membrane material and thus higher immobilization is achieved for polysulfon...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.10.018

    authors： Gupta S,Yogesh,Javiya S,Bhambi M,Pundir CS,Singh K,Bhattacharya A

    更新日期：2008-03-01 00:00:00

  • Cellulose hydrogel with tunable shape and mechanical properties: From rigid cylinder to soft scaffold.

    abstract：:Cellulose hydrogel from aqueous solution of lithium bromide demonstrated excellent tunability of mechanical property and shape. A series of compression tests showed that cellulose hydrogel covered a wide range of mechanical property, where the compressive Young's modulus was controllable from 30 kPa to 1.3 MPa by chan...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.071

    authors： Isobe N,Komamiya T,Kimura S,Kim UJ,Wada M

    更新日期：2018-10-01 00:00:00

  • Regulation of the equilibrium between G-quadruplex and duplex DNA in promoter of human c-myc oncogene by a pyrene derivative.

    abstract：:It has been established that the equilibrium between duplex and G-quadruplex of the nuclease hypersensitivity element III1 (NHE III1) in human c-myc promoter is linked with this gene's transcription. Using NMR and ESI-MS, we have found a pyrene derivative, DMAPP, is able to modulate this equilibrium and, thus, might h...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2011.05.024

    authors： Zhang Z,He X,Yuan G

    更新日期：2011-12-01 00:00:00

  • Effects of various oil extraction methods on the gelatinization and retrogradation properties of starches isolated from tigernut (Cyperus esculentus) tuber meals.

    abstract：:Gelatinization and retrogradation characteristics of starches from tigernut (Cyperus esculentus) tuber before and after various oil extraction processes were studied in this investigation. The results indicated that starches isolated from tigernut tuber after the various oil extraction processes varied significantly i...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.252

    authors： Liu HM,Yan YY,Liu XX,Ma YX,Wang XD

    更新日期：2020-08-01 00:00:00

  • CR-LAAO antileukemic effect against Bcr-Abl(+) cells is mediated by apoptosis and hydrogen peroxide.

    abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the presence of the Bcr-Abl tyrosine kinase protein, which confers resistance to apoptosis in leukemic cells. Tyrosine kinase inhibitors (TKIs) are effectively used to treat CML; however, CML patients in the advanced (CML-AP) and chronic ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.01.069

    authors： Burin SM,Ghisla S,Ouchida AT,Aissa AF,Coelho MG,Costa TR,Marsola AP,Pinto-Simões B,Antunes LM,Curti C,Sampaio SV,de Castro FA

    更新日期：2016-05-01 00:00:00

  • Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.

    abstract：:Astragalus polysaccharide (APS) is a bioactive macromolecule, which has been used to alleviate the development of Parkinson's disease (PD), while its mechanism is still unresolved. As is generally accepted that autophagy has an important link with PD, thus it is reasonable to hypothesize that APS was involved in autop...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.02.282

    authors： Tan Y,Yin L,Sun Z,Shao S,Chen W,Man X,Du Y,Chen Y

    更新日期：2020-06-15 00:00:00

  • Durable antibacterial and UV protections of in situ synthesized zinc oxide nanoparticles onto cotton fabrics.

    abstract：:Herein we represent a new discovery based on amine material called hexamethyltriethylene tetramine (HMTETA). We have observed that when an aqueous solution of Zn(NO3)·6H2O was added to aqueous solution of HMTETA followed by shaking for a time, the colorless solution was converted to milky color under the alkaline medi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.11.003

    authors： Shaheen TI,El-Naggar ME,Abdelgawad AM,Hebeish A

    更新日期：2016-02-01 00:00:00

  • Amphiphilic graft copolymeric micelle using dextrin and poly (N-vinyl caprolactam) via RAFT polymerization: Development and application.

    abstract：:Dextrin and poly (N-vinyl caprolactam) based amphiphilic graft copolymer has recently been developed using RAFT polymerization. The prepared graft copolymer has been characterized in details using FTIR and 1H NMR spectral analyses, GPC, TGA, FESEM, TEM and DLS analyses. GPC analysis results indicate that the polymeriz...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.198

    authors： Pal A,Sarkar AN,Karmakar PD,Pal S

    更新日期：2018-11-01 00:00:00

  • A comparative study of the suitability of different cereal straws for lignocellulose nanofibers isolation.

    abstract：:The aim of this work is to study the suitability of different soda cereal straw pulps (wheat, barley, corn and oats) to produce lignocellulose nanofibers (LCNF). For the study of the influence of the composition and physical characteristics, the pulps were characterized, observing that the physical characteristics do ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.05.156

    authors： Espinosa E,Sánchez R,Otero R,Domínguez-Robles J,Rodríguez A

    更新日期：2017-10-01 00:00:00