The hematology laboratory's response to the COVID-19 pandemic: A scoping review.

abstract：:Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in myelodsplastic syndrome (MDS). The identification of more inactivated tumor suppressor genes contributing to the development o...

journal_title：International journal of laboratory hematology

authors： Qian J,Yao DM,Lin J,Wang YL,Han LX,Xu WR,Wu CY

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:The direct thrombin inhibitor dabigatran interferes with thrombophilia screening and with the diagnosis of hemostasis disorders that develop during treatment with the anticoagulant. In vitro addition of idarucizumab, a humanized antibody fragment that binds dabigatran, to plasma samples containing dabigatr...

journal_title：International journal of laboratory hematology

authors： Jacquemin M,Toelen J,Feyen L,Schoeters J,Van Horenbeeck I,Vanlinthout I,Debasse M,Vanassche T,Peerlinck K,Verhamme P

更新日期：2018-08-01 00:00:00

abstract：INTRODUCTION:New methods for coagulation tests require careful assessment before routine use. We evaluated the analytical performance of five new coagulation assays for measuring prothrombin time (PT) and activated partial thromboplastin time (aPTT). METHODS:PT Rec, PT Owren, aPTT, aPTT Lupus and aPTT Screen assays (R...

journal_title：International journal of laboratory hematology

authors： Kitchen S,Geisen U,Kappelmayer J,Quehenberger P,Drieß J,Lowe A,Jones R,Boehm JG,Miles G,Rozsnyai G

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:The body fluid mode of the Sysmex XN-2000 hematology analyzer differentiates cells into mononuclear and polymorphonuclear white blood cells (WBC) and high-fluorescent cells (HFC). The aim of this study was to evaluate the performance of the HFC count for detecting malignant cells in serous body fluids. ME...

journal_title：International journal of laboratory hematology

authors： Labaere D,Boeckx N,Geerts I,Moens M,Van den Driessche M

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:Women are at higher risk of venous thromboembolism (VTE) during pregnancy and the puerperium. Global coagulation assays (GCAs), including thromboelastography (TEG), thrombin generation using the calibrated automated thrombogram (CAT) and fibrin generation using the overall haemostatic potential assay (OHP)...

journal_title：International journal of laboratory hematology

authors： O'Keefe D,Lim HY,Tham J,Ho P,Hui L

更新日期：2020-11-10 00:00:00

abstract：INTRODUCTION:Thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening thrombotic microangiopathy (TMA) characterized by the severe deficiency of ADAMTS13 activity (<10%). Rapid ADAMTS13 testing is crucial for early diagnosis and optimal management of TTP patients and other TMAs. The objective of this study ...

journal_title：International journal of laboratory hematology

authors： Pascual C,Nieto JM,Fidalgo T,Seguí IG,Díaz-Ricart M,Docampo MF,Del Rio J,Salinas R

更新日期：2020-12-02 00:00:00

abstract：INTRODUCTION:Thrombocytopenia-absent radius (TAR) syndrome is a rare autosomal recessive disease. Patients are compound heterozygotes for a loss-of-function allele, which in most cases is a large genomic deletion on chromosome 1q21.1 containing the RBM8A gene, and a noncoding variant located in the 5'UTR (rs139428292) ...

journal_title：International journal of laboratory hematology

authors： Nicchia E,Giordano P,Greco C,De Rocco D,Savoia A

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Capillary electrophoresis (CE) is a high-resolution method for detection of hemoglobin Constant Spring (Hb CS). METHODS:The levels of Hb CS quantified by CE were compared among three groups of samples including heterozygote and homozygote of Hb CS as well as Hb H-CS disease classified by DNA molecular dia...

journal_title：International journal of laboratory hematology

authors： Pornprasert S,Panyasai S,Waneesorn J,Kongthai K,Singboottra P

更新日期：2012-04-01 00:00:00

abstract：INTRODUCTION:In the cytogenetically normal population of AML (CN-AML), FLT3-ITD-positive and wild-type NPM1 is correlated with a worse outcome, and FLT3-ITD-negative with NPM1-mut is correlated with a better outcome. This leaves a large subpopulation of CN-AML patients without NPM1 or FLT3-ITD mutations with heterogene...

journal_title：International journal of laboratory hematology

authors： Guo RJ,Atenafu EG,Schimmer AD,Minden MD,Chang H

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:Physiological changes during pregnancy affect routine tests for iron deficiency. The reticulocyte haemoglobin equivalent (RET-He) and serum-soluble transferrin receptor (sTfR) assay are newer diagnostic parameters for the detection of iron deficiency, combined in the Thomas diagnostic plot. We used this pl...

journal_title：International journal of laboratory hematology

authors： Weyers R,Coetzee MJ,Nel M

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Severe COVID-19 is often compounded by a prothrombotic state that is associated with poor outcomes. In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding ADAMTS13 activity/VWF:Ag ratio, in patients with COVID-19 and for associations with ...

journal_title：International journal of laboratory hematology

authors： Henry BM,Benoit SW,de Oliveira MHS,Lippi G,Favaloro EJ,Benoit JL

更新日期：2020-12-03 00:00:00

abstract：INTRODUCTION:TET2, a member of the Ten-Eleven translocation gene family, catalyzes the conversion of 5-methylcytosine to 5-hydroxymethylcytosine in DNA. Low expression of TET2 has been reported as a prognostic factor for several types of malignancies in adult patients. However, there have been few data on the effect of...

journal_title：International journal of laboratory hematology

authors： Zhang P,Weng WW,Chen P,Zhang Y,Ruan JF,Ba DD,Xu WQ,Tang YM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:White blood cell (WBC) counts are used to monitor bone marrow function and to screen for infections. The HemoCue WBC DIFF Point-Of-Care (POC) instrument classifies WBCs through cell image recognition. To evaluate its suitability for monitoring cancer patients, we examined its performance in samples from pati...

journal_title：International journal of laboratory hematology

authors： Kur DK,Agersnap N,Holländer NH,Pedersen OBV,Friis-Hansen L

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:The Sysmex XP-300(®) (XP-300) is a new, fully automated hematology analyzer, designed to generate complete blood counts (CBC) with 3-part differential. In our study, the XP-300 was evaluated as a point-of-care (POC) analyzer in an oncology setting. In which blood samples from patients with different pathol...

journal_title：International journal of laboratory hematology

authors： van Dievoet MA,Louagie H,Ghys T

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Mean platelet volume (MPV) and platelet (PLT) count are the two major parameters that reflect the functions and activities of PLTs. The associations of MPV and PLT count with the occurrence and prognosis of stroke have not been fully clarified. This study aimed to investigate the association of MPV and PLT...

journal_title：International journal of laboratory hematology

authors： Du J,Wang Q,He B,Liu P,Chen JY,Quan H,Ma X

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:It is widely recognized that plasma cells (PCs) are under-represented in flow cytometry (FC) studies, but the causes of this phenomenon are poorly understood. We sought to study potential variables that affect PC recovery by flow cytometry (FC) in the analysis of plasma cell myeloma (PCM). METHODS:We retr...

journal_title：International journal of laboratory hematology

authors： Cogbill CH,Spears MD,Vantuinen P,Harrington AM,Olteanu H,Kroft SH

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:To retrospectively analyze epidemiological, clinical and hematological characteristics of COVID-19 patients. METHODS:The demographic, symptoms, and physiological parameters of 88 patients were collected and analyzed. The performance of complete blood count (CBC) indexes for monitoring and predicting the s...

journal_title：International journal of laboratory hematology

authors： Zhang H,Cao X,Kong M,Mao X,Huang L,He P,Pan S,Li J,Lu Z

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of immune tolerance induction (ITI) treatment. This study monitored the relative distribution of ...

journal_title：International journal of laboratory hematology

authors： Irigoyen MB,Primiani L,Felippo M,Candela M,de Bracco MME,Galassi NV

更新日期：2017-12-01 00:00:00

abstract：:Using previously described procedures, this study quantified T-cell, T-cell subset, B-cell and NK-cell populations with the CD-Sapphire haematology analyser in a series of patients with mild to moderate lymphocytosis. Lymphocyte counts ranged from 6.0 to 14.9 x 10(9)/l, with 86/97 being <10.0 x 10(9)/l. Immunophenotyp...

journal_title：International journal of laboratory hematology

authors： Molero T,Lemes A,DE LA Iglesia S,Scott CS

更新日期：2007-12-01 00:00:00

abstract：:In the 8 years since the publication of the 4th edition of the WHO Classification of Hematopoietic and Lymphoid Tumours in 2008, there has been rapid accumulation of knowledge in the molecular genetics, biology, clinical behavior of many hematologic malignancies. Concepts and models have advanced to the point at which...

journal_title：International journal of laboratory hematology

authors： Hsi ED

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Multiple types of mutations in the BCR-ABL1 kinase domain have been reported. We previously reported a common alternatively spliced BCR-ABL mRNA with a 35-nucleotide insertion (35INS). We report three novel alternative splicing mutants expressed as the dominant transcripts in patient with chronic myelogeno...

journal_title：International journal of laboratory hematology

authors： Ma W,Giles F,Zhang X,Wang X,Zhang Z,Lee TS,Yeh CH,Albitar M

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Immature platelet fraction (IPF) is a parameter for reticulated platelets. A high percentage IPF (%-IPF) is indicative of consumptive or recovering thrombocytopenic disorders in contrast to a low %-IPF seen in aplastic states. Absolute IPF (A-IPF) specifically reflects the number of immature platelets in c...

journal_title：International journal of laboratory hematology

authors： Ko YJ,Kim H,Hur M,Choi SG,Moon HW,Yun YM,Hong SN

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:Early diagnosis and identification of potential critical cases for timely treatment are crucial for COVID-19 patients. The aim of this study was to analyze the diagnostic and prognostic implications of WBC and cell population data (CPD) abnormalities related to COVID-19 at disease onset. METHODS:Baseline ...

journal_title：International journal of laboratory hematology

authors： Naoum FA,Ruiz ALZ,Martin FHO,Brito THG,Hassem V,Oliveira MGL

更新日期：2020-11-15 00:00:00

abstract：INTRODUCTION:This study was aimed to compare the analytical performance of traditional and new parameters and morphological flags of CAL-8000 and XN-9000. The automated differential leukocyte count (DIFF profile) and morphological flags were compared with optical microscopy (OM). METHODS:A total of 1025 peripheral blo...

journal_title：International journal of laboratory hematology

authors： Buoro S,Mecca T,Seghezzi M,Manenti B,Azzarà G,Dominoni P,Crippa A,Ottomano C,Lippi G

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:To measure direct factor Xa inhibitor (apixaban, edoxaban, rivaroxaban) concentrations, dedicated chromogenic anti-Xa assays are recommended as suitable methods to provide rapid drug quantification. Moreover, the high-performance liquid chromatography with ultraviolet detection (HPLC-UV) is reported as a r...

journal_title：International journal of laboratory hematology

authors： Cini M,Legnani C,Padrini R,Cosmi B,Dellanoce C,De Rosa G,Marcucci R,Pengo V,Poli D,Testa S,Palareti G

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:Aberrant activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway leads to deregulated proliferation, differentiation, or apoptosis of normal cells. One of the members of this family, JAK2, plays a very important role in metabolizing carcinogens and medications. This...

journal_title：International journal of laboratory hematology

authors： Zhong Y,Wu J,Ma R,Cao H,Wang Z,Ding J,Cheng L,Feng J,Chen B

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. METHODS:This review summarizes author's experience with ordering and re...

journal_title：International journal of laboratory hematology

authors： Hayward CPM

更新日期：2018-05-01 00:00:00

abstract：:Flow cytometry (FCM) allows scientists to rapidly quantify up to 50 parameters for millions of cells per sample. The bottleneck in the application of the technology is data analysis, and the high number of parameters measured by the current generation of instruments requires the use of advanced computational algorithm...

journal_title：International journal of laboratory hematology

authors： Montante S,Brinkman RR

更新日期：2019-05-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role of genetic and epigenetic changes has undergone significant advancements. Newer diagnostic and prognostic classifications have increasingly incorporated such information, and novel therapies have been developed to target specifi...

journal_title：International journal of laboratory hematology

authors： Ohgami RS,Arber DA

更新日期：2015-05-01 00:00:00

abstract：:B-lineage lymphoproliferative disorders (LPD) are rather frequent diseases, associated with specific clinical or biological features but also sometimes of fortuitous discovery. Multiparameter flow cytometry plays a major role for a rapid diagnostic indication, on peripheral blood or bone marrow samples in most instanc...

journal_title：International journal of laboratory hematology

authors： Debord C,Wuillème S,Eveillard M,Theisen O,Godon C,Le Bris Y,Béné MC

更新日期：2020-06-01 00:00:00