Abstract:
INTRODUCTION:Mean platelet volume (MPV) and platelet (PLT) count are the two major parameters that reflect the functions and activities of PLTs. The associations of MPV and PLT count with the occurrence and prognosis of stroke have not been fully clarified. This study aimed to investigate the association of MPV and PLT count with the development and prognosis of first-ever ischemic and hemorrhagic stroke in order to provide evidence for early diagnosis and treatment of both strokes. METHODS:This study included 281 first-ever ischemic stroke and 164 first-ever hemorrhagic stroke patients between 2010 and 2012. All participants received routine blood tests within 2 h after admission and were categorized into good or poor prognosis group based on the Modified Rankin Scale (mRS) score. MPV and PLT counts were transformed into categorical variables and their association with the occurrence and prognosis of both strokes was evaluated by multivariate logistic regression. RESULTS:The risk of ischemic and hemorrhagic stroke in MPV group (>13 fL) was 22.17 and 5.21 times higher compared with normal MPV group. The PLT count was positively correlated with the risk of ischemic stroke, but negatively correlated with the risk of hemorrhagic stroke. MPV and PLT count was not correlated with the prognosis of either stroke. CONCLUSIONS:Increased MPV is an independent risk factor for both strokes. Elevated PLT count increases the risk for ischemic stroke, but decreases the risk for hemorrhagic stroke. However, neither MPV nor PLT count has significant association with the prognosis of either stroke.
journal_name
Int J Lab Hematoljournal_title
International journal of laboratory hematologyauthors
Du J,Wang Q,He B,Liu P,Chen JY,Quan H,Ma Xdoi
10.1111/ijlh.12474subject
Has Abstractpub_date
2016-06-01 00:00:00pages
233-9issue
3eissn
1751-5521issn
1751-553Xjournal_volume
38pub_type
临床试验,杂志文章abstract:INTRODUCTION:Women are at higher risk of venous thromboembolism (VTE) during pregnancy and the puerperium. Global coagulation assays (GCAs), including thromboelastography (TEG), thrombin generation using the calibrated automated thrombogram (CAT) and fibrin generation using the overall haemostatic potential assay (OHP)...
journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章,评审
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journal_title:International journal of laboratory hematology
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doi:10.1111/j.1751-553X.2007.00986.x
更新日期:2008-10-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2008.01111.x
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abstract:INTRODUCTION:It is widely recognized that plasma cells (PCs) are under-represented in flow cytometry (FC) studies, but the causes of this phenomenon are poorly understood. We sought to study potential variables that affect PC recovery by flow cytometry (FC) in the analysis of plasma cell myeloma (PCM). METHODS:We retr...
journal_title:International journal of laboratory hematology
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 临床试验,杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 临床试验,杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2012.01421.x
更新日期:2012-10-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2009.01178.x
更新日期:2010-04-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/ijlh.12254
更新日期:2015-04-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/ijlh.13001
更新日期:2019-06-01 00:00:00
abstract::The majority, if not all, of human cell types secrete extracellular vesicles (EVs) into their environment, at least partly as a means of intercellular communication. These secreted vesicles can be detected in most bodily fluids including blood, urine, and saliva. The number of secreted vesicles and their composition i...
journal_title:International journal of laboratory hematology
pub_type: 杂志文章,评审
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更新日期:2014-06-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/ijlh.12897
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章,实务指引
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更新日期:2012-02-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2007.00934.x
更新日期:2007-12-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章,评审
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更新日期:2020-11-12 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2007.00962.x
更新日期:2008-08-01 00:00:00
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journal_title:International journal of laboratory hematology
pub_type: 杂志文章
doi:10.1111/j.1751-553X.2010.01295.x
更新日期:2011-08-01 00:00:00
abstract:INTRODUCTION:Monitoring of factor IX (FIX) replacement therapy in haemophilia B relies on accurate coagulation assays. However, considerable interlaboratory variability has been reported for one-stage clotting (OSC) assays. This study aimed to evaluate the real-world, interlaboratory variability of routine FIX activity...
journal_title:International journal of laboratory hematology
pub_type: 杂志文章,多中心研究
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更新日期:2020-06-01 00:00:00