Different kinetic patterns of BCR-ABL transcript levels in imatinib-treated chronic myeloid leukemia patients after achieving complete cytogenetic response.

abstract：INTRODUCTION:Pathogen Inactivation allows to overcome microbial contamination and growth related to storage of platelets concentrates (PC) at room temperature. The aim of our study was to evaluate the platelet storage lesion extending the storage period of pathogen inactivated platelet concentrates over 7 days using an...

journal_title：International journal of laboratory hematology

authors： Diquattro M,De Francisci G,Bonaccorso R,Tagliavia AM,Marcatti M,Palma B,Agliastro R

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:White blood cell (WBC) counts are used to monitor bone marrow function and to screen for infections. The HemoCue WBC DIFF Point-Of-Care (POC) instrument classifies WBCs through cell image recognition. To evaluate its suitability for monitoring cancer patients, we examined its performance in samples from pati...

journal_title：International journal of laboratory hematology

authors： Kur DK,Agersnap N,Holländer NH,Pedersen OBV,Friis-Hansen L

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Dehydration, fluid shifts or changes in coagulation occurring during air travel can trigger distinct reactions in the haematological system. Athletes are concerned that these effects might impair sporting performance, increase the risk of thrombosis or cause abnormalities in blood values that might be mist...

journal_title：International journal of laboratory hematology

authors： Schumacher YO,Klodt F,Nonis D,Pottgiesser T,Alsayrafi M,Bourdon PC,Voss SC

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:The Sysmex XN-series is a new automated hematology analyzer designed to improve the accuracy of cell counts and the specificity of the flagging events. METHODS:The basic characteristics and the performance of new measurement channels of the XN were evaluated and compared with the Sysmex XE-2100 and the ma...

journal_title：International journal of laboratory hematology

authors： Seo JY,Lee ST,Kim SH

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Argatroban is licensed for patients with heparin-induced thrombocytopenia and monitoring is conventionally by activated partial thromboplastin time (APTT) ratio with a target of 1.5-3.0 and not exceeding 100 s. The APTT may be influenced by coagulopathies, lupus anticoagulant and raised FVIII levels. Variabl...

journal_title：International journal of laboratory hematology

authors： Guy S,Kitchen S,Maclean R,Van Veen JJ

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:To retrospectively analyze epidemiological, clinical and hematological characteristics of COVID-19 patients. METHODS:The demographic, symptoms, and physiological parameters of 88 patients were collected and analyzed. The performance of complete blood count (CBC) indexes for monitoring and predicting the s...

journal_title：International journal of laboratory hematology

authors： Zhang H,Cao X,Kong M,Mao X,Huang L,He P,Pan S,Li J,Lu Z

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Malaria is a life-threatening infectious disease, which has been for long confined to specific endemic areas. Nevertheless, the recent increase in immigration flows from endemic regions and imported cases has reemphasized many diagnostic challenges in Western countries, thus paving the way to introduce rap...

journal_title：International journal of laboratory hematology

authors： Buoro S,Manenti B,Seghezzi M,Moioli V,Bagorria M,Callegaro A,Ottomano C,Lippi G

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Iron is essential for hemoglobin synthesis during terminal erythropoiesis. To supply adequate iron the carrier transferrin is required together with transferrin receptor endosomal cycle and normal mitochondrial iron utilization. Iron and iron protein deficiencies result in different types of anemia. Iron-def...

journal_title：International journal of laboratory hematology

authors： Camaschella C,Pagani A,Nai A,Silvestri L

更新日期：2016-05-01 00:00:00

abstract：INTRODUCTION:It is widely recognized that plasma cells (PCs) are under-represented in flow cytometry (FC) studies, but the causes of this phenomenon are poorly understood. We sought to study potential variables that affect PC recovery by flow cytometry (FC) in the analysis of plasma cell myeloma (PCM). METHODS:We retr...

journal_title：International journal of laboratory hematology

authors： Cogbill CH,Spears MD,Vantuinen P,Harrington AM,Olteanu H,Kroft SH

更新日期：2015-12-01 00:00:00

abstract：:Molecular monitoring of the BCR-ABL1 transcript in chronic myelogenous leukemia (CML) using quantitative real-time PCR (RQ-PCR) can be performed using either bone marrow (BM) or peripheral blood (PB). However, a recent report by Stock et al. [International Journal of Oncology 28 (2006) 1099] questioned the reliability...

journal_title：International journal of laboratory hematology

authors： Ballestrero A,Cirmena G,Dominietto A,Garuti A,Rocco I,Cea M,Moran E,Nencioni A,Miglino M,Raiola AM,Bacigalupo A,Patrone F

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Beta globin deletion/duplication analysis may serve as a useful adjunct to sequence analysis. Our purpose was to develop a robust assay for beta globin deletion/duplication analysis and determine its role in evaluating patients with beta thalassemia. METHODS:A single tube semi-quantitative fluorescent PCR...

journal_title：International journal of laboratory hematology

authors： Mikula M,Buller-Burckle A,Gallivan M,Sun W,Franklin CR,Strom CM

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:New generation osmotic gradient ektacytometry has become a powerful procedure for measuring red blood cell deformability and therefore for the diagnosis of red blood cell membrane disorders. In this study, we aim to provide further support to the usefulness of osmotic gradient ektacytometry for the differe...

journal_title：International journal of laboratory hematology

authors： Llaudet-Planas E,Vives-Corrons JL,Rizzuto V,Gómez-Ramírez P,Sevilla Navarro J,Coll Sibina MT,García-Bernal M,Ruiz Llobet A,Badell I,Velasco-Puyó P,Dapena JL,Mañú-Pereira MM

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Immediate reporting of critical values or test results significantly outside the normal range has a growing role in the management of patients, especially in life-threatening conditions. Due to the lack of international consensus, diverse approaches are used for determination of thresholds, reporting, docume...

journal_title：International journal of laboratory hematology

authors： Dorgalaleh A,Shiravand Y,Dabbagh A,Tabibian S,Hosseini MS,Mansouri Tourghabeh H,Rashidpanah J,Narouei F,Shams M,Gholami MS,Saneei Moghaddam E,Shahreki H

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:The study aims to evaluate the diagnostic utility of thyrogastric immune features in the identification of intrinsic factor antibody negative (IFA -ve) pernicious anaemia (PA) patients. METHODS:Clinico-pathological features of 'intrinsic factor antibody positive (IFA +ve) PA' and 'IFA -ve presumed PA' Chi...

journal_title：International journal of laboratory hematology

authors： Chan J,Chan HY

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Thrombotic complications are a main concern in patients with myeloproliferative neoplasms. Recently, a gain-of-function mutation of the gene encoding the JAK2 tyrosine kinase that results in a valine-to-phenylalanine substitution at position 617 (V617F) has been described. Since the description of the JAK2...

journal_title：International journal of laboratory hematology

authors： Xavier SG,Gadelha T,Rezende SM,Zalcberg IR,Spector N

更新日期：2011-04-01 00:00:00

abstract：:B-lineage lymphoproliferative disorders (LPD) are rather frequent diseases, associated with specific clinical or biological features but also sometimes of fortuitous discovery. Multiparameter flow cytometry plays a major role for a rapid diagnostic indication, on peripheral blood or bone marrow samples in most instanc...

journal_title：International journal of laboratory hematology

authors： Debord C,Wuillème S,Eveillard M,Theisen O,Godon C,Le Bris Y,Béné MC

更新日期：2020-06-01 00:00:00

abstract：:Complex chromosomal aberrations (CCA) can be detected in a substantial proportion of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which are associated with very poor prognosis. Conventional cytogenetics (CC) cannot accurately define the specific alterations in CCA. Multiplex fluorescence in situ h...

journal_title：International journal of laboratory hematology

authors： Xu W,Li JY,Liu Q,Zhu Y,Pan JL,Qiu HR,Xue YQ

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Monitoring of factor IX (FIX) replacement therapy in haemophilia B relies on accurate coagulation assays. However, considerable interlaboratory variability has been reported for one-stage clotting (OSC) assays. This study aimed to evaluate the real-world, interlaboratory variability of routine FIX activity...

journal_title：International journal of laboratory hematology

authors： Sommer JM,Sadeghi-Khomami A,Barnowski C,Wikén M,Willemze AJ

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:To study the effect of bortezomib alone or in combination with daunorubicin (DNR) on an mdr1 single-factor drug-resistant leukemia cell line K562/MDR1, a multifactor-resistant cell line K562/A02, a drug-sensitive cell line K562, and primary cells from acute myeloid leukemia patients. METHODS:The cell line...

journal_title：International journal of laboratory hematology

authors： Zheng B,Zhou R,Gong Y,Yang X,Shan Q

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:The body fluid mode of the Sysmex XN-2000 hematology analyzer differentiates cells into mononuclear and polymorphonuclear white blood cells (WBC) and high-fluorescent cells (HFC). The aim of this study was to evaluate the performance of the HFC count for detecting malignant cells in serous body fluids. ME...

journal_title：International journal of laboratory hematology

authors： Labaere D,Boeckx N,Geerts I,Moens M,Van den Driessche M

更新日期：2015-10-01 00:00:00

abstract：INTRODUCTION:FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of immune tolerance induction (ITI) treatment. This study monitored the relative distribution of ...

journal_title：International journal of laboratory hematology

authors： Irigoyen MB,Primiani L,Felippo M,Candela M,de Bracco MME,Galassi NV

更新日期：2017-12-01 00:00:00

abstract：:Although most patients with peripheral T-cell lymphoma (PTCL) show clonal rearrangement of T-cell receptor genes, few PTCLs show recurrent chromosomal abnormalities. We describe here a rare chromosomal rearrangement, t(14;19)(q11.2;q13.3), in a Lennert's lymphoma, a variant of PTCL, not otherwise specified. Sequential...

journal_title：International journal of laboratory hematology

authors： Shin SY,Jang S,Park CJ,Chi HS,Lee KH,Huh J,Seo EJ

更新日期：2012-06-01 00:00:00

abstract：:The performance of factor VII (FVII) assays currently used by clinical laboratories was examined in North American Specialized Coagulation Laboratory Association (NASCOLA) proficiency tests. Data from 12 surveys conducted between 2008 and 2010, involving 20 unique specimens plus four repeat-tested specimens, were anal...

journal_title：International journal of laboratory hematology

authors： Zantek ND,Hsu P,Refaai MA,Ledford-Kraemer M,Meijer P,Van Cott EM

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:The MRD status detected using multiparameter flow cytometry (MFC) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) has crucial prognostic value for patients with acute myeloid leukemia (AML) in morphologic complete remission (CR). We designed a novel panel of antibodies to identify aberr...

journal_title：International journal of laboratory hematology

authors： Wang Z,Guo M,Zhang Y,Xu S,Cheng H,Wu J,Zhang W,Hu X,Yang J,Wang J,Tang G

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:In acute myeloid leukemia (AML), it has been shown that AML-derived cells often remain sensitive to autophagy-inducing stimuli, leading to the idea that harnessing the autophagy can be pertinent to AML cytotoxic therapy. Despite this promising notion, to date, there is no comprehensive study addressing aut...

journal_title：International journal of laboratory hematology

authors： Zare-Abdollahi D,Safari S,Movafagh A,Ghadiani M,Tabarraee M,Riazi-Isfahani S,Gorji S,Keyvan L,Gachkar L

更新日期：2016-04-01 00:00:00

abstract：:Prediction of the timing of platelet recovery after chemotherapy and hematopoietic stem cell transplantation (HSCT) allows for optimal platelet transfusion. We assessed the clinical utility of the percentage value of the immature platelet fraction (IPF%) monitored using an XE-2100 automated hematology analyzer to pred...

journal_title：International journal of laboratory hematology

authors： Yamaoka G,Kubota Y,Nomura T,Inage T,Arai T,Kitanaka A,Saigo K,Iseki K,Baba N,Taminato T

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:The IgV(H) mutational status of B-cell chronic lymphocytic leukemia (B-CLL) is of prognostic value. Expression of ZAP-70 in B-CLL is a surrogate marker for IgV(H) unmutated (UM). As determination of IgV(H) mutational status involves a methodology currently unavailable for most clinical laboratories, it is ...

journal_title：International journal of laboratory hematology

authors： Marquez ME,Deglesne PA,Suarez G,Romano E

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Atypical chronic lymphocytic leukemia (aCLL) is a morphologic variant found in approximately 25% of patients with chronic lymphocytic leukemia (CLL). Although aCLL has a more aggressive course compared to typical CLL (tCLL), it is not usually reported. This retrospective study used digital microscopy to mo...

journal_title：International journal of laboratory hematology

authors： Marionneaux S,Maslak P,Keohane EM

更新日期：2014-08-01 00:00:00

abstract：:This 22-year-old women presented to the ante-natal clinic of this hospital for prenatal screening for beta-thalassemia. Cation exchange high performance liquid chromatography (HPLC) using 'Beta Thalassemia Short Program' on Bio-Rad 'Variant' system revealed HbC value of 81.6%. The CBC showed microcytic hypochromic ane...

journal_title：International journal of laboratory hematology

authors： Kumar S,Rana M,Handoo A,Saxena R,Verma IC,Bhargava M,Sood SK

更新日期：2007-10-01 00:00:00

abstract：:The paucity of clinical reports in the world literature suggests that, as a disease entity, haemoglobin SE compound heterozygosity is of negligible importance. In view of the significant community prevalence of this haemoglobinopathy in the Sultanate of Oman where it is the second most prevalent sickling disorder, a h...

journal_title：International journal of laboratory hematology

authors： Knox-Macaulay HH,Ahmed MM,Gravell D,Al-Kindi S,Ganesh A

更新日期：2007-08-01 00:00:00