Morphologic identification of atypical chronic lymphocytic leukemia by digital microscopy.

abstract：INTRODUCTION:Monocytosis is a frequent trigger for blood smear review in a routine hematology laboratory whereas chronic myelomonocytic leukemia (CMML) is infrequent and arises mostly in elderly patients. In order to define the best workflow for monocytosis, we studied three diagnostic approaches: the classical morphol...

journal_title：International journal of laboratory hematology

authors： Zhu J,Sourdeau E,Aubert H,Clauser S,Maillon A,Capron C,Jondeau K,Ronez E,Schillinger F,Garnache-Ottou F,Cornet E,Bardet V

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:In the cytogenetically normal population of AML (CN-AML), FLT3-ITD-positive and wild-type NPM1 is correlated with a worse outcome, and FLT3-ITD-negative with NPM1-mut is correlated with a better outcome. This leaves a large subpopulation of CN-AML patients without NPM1 or FLT3-ITD mutations with heterogene...

journal_title：International journal of laboratory hematology

authors： Guo RJ,Atenafu EG,Schimmer AD,Minden MD,Chang H

更新日期：2017-08-01 00:00:00

abstract：INTRODUCTION:The STA R Max® 2 is a new coagulation analyser developed by Diagnostica Stago, able to perform clotting, chromogenic and immuno-turbidimetric tests. A pre-analytical module build into the cap-piercing needle performs the sample integrity verification (sample tube filling and measurement of haemolysis, icte...

journal_title：International journal of laboratory hematology

authors： Cupaiolo R,Govaerts D,Blauwaert M,Cauchie P

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Lnc-IRF2-3 and Lnc-ZNF667-AS1 were recently studied as a positive biomarker for many tumor cells. However, experimental studies found that they are associated with worse outcomes in B-CLL. METHODS:A prospective case study was conducted on 135 B-CLL patients that were compared to thirty healthy controls. The...

journal_title：International journal of laboratory hematology

authors： El-Khazragy N,Esmaiel MA,Mohamed MM,Hassan NS

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:While hyperparasitemia is considered an important indicator for the development of severe malaria, there is currently no consensus on the quantitative definition of hyperparasitemia. This study was conducted to establish a cutoff point for peripheral parasitemia among patients with Plasmodium falciparum ma...

journal_title：International journal of laboratory hematology

authors： Tangpukdee N,Krudsood S,Kano S,Wilairatana P

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Women are at higher risk of venous thromboembolism (VTE) during pregnancy and the puerperium. Global coagulation assays (GCAs), including thromboelastography (TEG), thrombin generation using the calibrated automated thrombogram (CAT) and fibrin generation using the overall haemostatic potential assay (OHP)...

journal_title：International journal of laboratory hematology

authors： O'Keefe D,Lim HY,Tham J,Ho P,Hui L

更新日期：2020-11-10 00:00:00

abstract：INTRODUCTION:It is widely recognized that plasma cells (PCs) are under-represented in flow cytometry (FC) studies, but the causes of this phenomenon are poorly understood. We sought to study potential variables that affect PC recovery by flow cytometry (FC) in the analysis of plasma cell myeloma (PCM). METHODS:We retr...

journal_title：International journal of laboratory hematology

authors： Cogbill CH,Spears MD,Vantuinen P,Harrington AM,Olteanu H,Kroft SH

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:Thrombotic complications are a main concern in patients with myeloproliferative neoplasms. Recently, a gain-of-function mutation of the gene encoding the JAK2 tyrosine kinase that results in a valine-to-phenylalanine substitution at position 617 (V617F) has been described. Since the description of the JAK2...

journal_title：International journal of laboratory hematology

authors： Xavier SG,Gadelha T,Rezende SM,Zalcberg IR,Spector N

更新日期：2011-04-01 00:00:00

abstract：:The consistent multi-ethnic migrations of the last decades have considerably changed the epidemiology of the hemoglobinopathies. Healthy carriers of these conditions are present today in many nonendemic parts of the world, and severely affected children are now born where these diseases were previously rare or unknown...

journal_title：International journal of laboratory hematology

authors： Giordano PC

更新日期：2013-10-01 00:00:00

abstract：:Complex chromosomal aberrations (CCA) can be detected in a substantial proportion of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which are associated with very poor prognosis. Conventional cytogenetics (CC) cannot accurately define the specific alterations in CCA. Multiplex fluorescence in situ h...

journal_title：International journal of laboratory hematology

authors： Xu W,Li JY,Liu Q,Zhu Y,Pan JL,Qiu HR,Xue YQ

更新日期：2010-02-01 00:00:00

abstract：:Significant advances have been made in our understanding of the structural basis for altered cell function in various inherited red cell membrane disorders with reduced red cell survival and resulting hemolytic anemia. The current review summarizes these advances as they relate to defining the molecular and structural...

journal_title：International journal of laboratory hematology

authors： Narla J,Mohandas N

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Argatroban is licensed for patients with heparin-induced thrombocytopenia and monitoring is conventionally by activated partial thromboplastin time (APTT) ratio with a target of 1.5-3.0 and not exceeding 100 s. The APTT may be influenced by coagulopathies, lupus anticoagulant and raised FVIII levels. Variabl...

journal_title：International journal of laboratory hematology

authors： Guy S,Kitchen S,Maclean R,Van Veen JJ

更新日期：2015-12-01 00:00:00

abstract：INTRODUCTION:With the progression of blood analysis technology, hematology analyzers become more complex and diverse. How to choose a superb instrument is a challenge for the laboratories. In the essay, we studied whether the newest BC-6000 hematology analyzer meets the needs of a clinical hematology laboratory. METHO...

journal_title：International journal of laboratory hematology

authors： Shen Y,Cao J,Zhou Z,Wang Y,Shen Y,He J

更新日期：2019-10-01 00:00:00

abstract：:Several intracytoplasmic morphological changes in the plasma cells of multiple myeloma have been described previously. However, Auer rod-like inclusions are rarely found in these types of cells. Here, we report a case of multiple myeloma with Auer rod-like, needle-shaped intracytoplasmic inclusions in plasma cells. A ...

journal_title：International journal of laboratory hematology

authors： Hütter G,Nowak D,Blau IW,Thiel E

更新日期：2009-04-01 00:00:00

abstract：INTRODUCTION:Direct oral anticoagulants (DOAC) are commonly prescribed and measuring drug levels may be useful in a number of contexts. However, data on DOAC level measurement and their clinical utility in real-world studies are limited. METHODS:We carried out a 2-year retrospective cohort study of DOAC levels measure...

journal_title：International journal of laboratory hematology

authors： Denny NDR,Keighley L,Siganporia Z,Thachil J,Nash MJ

更新日期：2019-04-01 00:00:00

abstract：:Using previously described procedures, this study quantified T-cell, T-cell subset, B-cell and NK-cell populations with the CD-Sapphire haematology analyser in a series of patients with mild to moderate lymphocytosis. Lymphocyte counts ranged from 6.0 to 14.9 x 10(9)/l, with 86/97 being <10.0 x 10(9)/l. Immunophenotyp...

journal_title：International journal of laboratory hematology

authors： Molero T,Lemes A,DE LA Iglesia S,Scott CS

更新日期：2007-12-01 00:00:00

abstract：INTRODUCTION:Venous blood (VB) sampling for complete blood count (CBC) via venipuncture is the basic method for the daily evaluation of hematological patients. However, several issues during this process, such as venipuncture difficulty and repetitive attempts, may cause pain, phlebitis, hematomas, inadequate sampling,...

journal_title：International journal of laboratory hematology

authors： Oudatzis G,Tsagarakis NJ,Paterakis G,Vasileiou P,Xenou E,Maraki P,Pangrati T,Angelopoulou MK,Vassilakopoulos TP,Konstantopoulos K

更新日期：2020-10-01 00:00:00

abstract：:The diagnosis of iron deficiency in hospital patients can be difficult in the presence of inflammation. A raised serum transferrin receptor (sTfR) level is useful as a marker of iron deficiency as it is unaffected by inflammation. However, diseases that cause an increase in erythropoietic activity can also result in a...

journal_title：International journal of laboratory hematology

authors： Ong KH,Tan HL,Tam LP,Hawkins RC,Kuperan P

更新日期：2008-12-01 00:00:00

abstract：:Successful adoptive immunotherapy for leukemia depends on the generation of T cells that can specifically react with malignant cells. Dendritic cells (DCs) are important antigen-presenting cells in the development of antileukemia T-cell responses. Mononuclear cells (MNC) were isolated from peripheral blood or bone mar...

journal_title：International journal of laboratory hematology

authors： Tong XM,Yao HP,Qian WB,Zhu LF,Fu ZH,Huang ZL,Jin J

更新日期：2008-10-01 00:00:00

abstract：:Advances in lab-on-a-chip technologies enabled programmable, reconfigurable, and scalable manipulation of a variety of laboratory procedures. Samples, reagents, and fluids can be precisely controlled; buffer temperature, pH, and concentration control systems as well as a variety of detection systems can be integrated ...

journal_title：International journal of laboratory hematology

authors： Park S,Moon HS,Lee DS,Kim HC,Chun H

更新日期：2013-10-01 00:00:00

abstract：INTRODUCTION:To measure direct factor Xa inhibitor (apixaban, edoxaban, rivaroxaban) concentrations, dedicated chromogenic anti-Xa assays are recommended as suitable methods to provide rapid drug quantification. Moreover, the high-performance liquid chromatography with ultraviolet detection (HPLC-UV) is reported as a r...

journal_title：International journal of laboratory hematology

authors： Cini M,Legnani C,Padrini R,Cosmi B,Dellanoce C,De Rosa G,Marcucci R,Pengo V,Poli D,Testa S,Palareti G

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVES:To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs). METHODS:Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool-age children and school-age children. Venous b...

journal_title：International journal of laboratory hematology

authors： Li J,Zhang H,Huang X,Zhang J,Wu X

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:The workflow in clinical flow cytometry laboratories must constantly be reviewed to develop technical procedures that improve quality and productivity and reduce costs. Using the Beckman Coulter dry coating technology, we customized a ten-color tube with dried antibody reagents, designated the Duraclone sc...

journal_title：International journal of laboratory hematology

authors： Correia RP,Rajab A,Bento LC,Alexandre AM,Vaz AC,Schimidell D,Pedro EC,Perin FS,Nozawa ST,Barroso RS,Bacal NS

更新日期：2018-04-01 00:00:00

abstract：INTRODUCTION:Clinical reference intervals represent the normal range of clinical parameters for distinguishing healthy and sick individuals, and they show some variation among different populations. Many reference intervals are still lacking for the pediatric population in China. Thus, the aim of this study was to esta...

journal_title：International journal of laboratory hematology

authors： Sun Q,Yue Y,Tian Y,Wang Q

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. METHODS:This review summarizes author's experience with ordering and re...

journal_title：International journal of laboratory hematology

authors： Hayward CPM

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:The Sysmex XN-series is a new automated hematology analyzer designed to improve the accuracy of cell counts and the specificity of the flagging events. METHODS:The basic characteristics and the performance of new measurement channels of the XN were evaluated and compared with the Sysmex XE-2100 and the ma...

journal_title：International journal of laboratory hematology

authors： Seo JY,Lee ST,Kim SH

更新日期：2015-04-01 00:00:00

abstract：:Three major types of rearrangements are involved in acute myeloid leukemias (AML): t(8;21)(q22;q22), inv(16)(p13q22), and 11q23/MLL abnormalities. Their precise identification becomes essential for diagnosis, prognosis, and therapeutic choices. Resulting fusion transcripts (FT) are also powerful markers for monitoring...

journal_title：International journal of laboratory hematology

authors： Giusiano S,Formisano-Tréziny C,Benziane A,Maroc N,Picard C,Hermitte F,Taranger-Charpin C,Gabert J

更新日期：2010-08-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is a complex disease, for which our understanding of the role of genetic and epigenetic changes has undergone significant advancements. Newer diagnostic and prognostic classifications have increasingly incorporated such information, and novel therapies have been developed to target specifi...

journal_title：International journal of laboratory hematology

authors： Ohgami RS,Arber DA

更新日期：2015-05-01 00:00:00

abstract：INTRODUCTION:To study the effect of bortezomib alone or in combination with daunorubicin (DNR) on an mdr1 single-factor drug-resistant leukemia cell line K562/MDR1, a multifactor-resistant cell line K562/A02, a drug-sensitive cell line K562, and primary cells from acute myeloid leukemia patients. METHODS:The cell line...

journal_title：International journal of laboratory hematology

authors： Zheng B,Zhou R,Gong Y,Yang X,Shan Q

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:D-dimer (DD) assays are effective for the exclusion of deep-vein thrombosis (DVT), but point-of-care (POC) DD assays have not been fully evaluated. METHODS:We have compared five POC DD assays (Pathfast, Cardiac, Vidas, Stratus and NycoCard) with our routine DD method (Tinaquant), testing 60 samples from p...

journal_title：International journal of laboratory hematology

authors： Antovic JP,Höög Hammarström K,Forslund G,Eintrei J,Sten-Linder M

更新日期：2012-10-01 00:00:00