Osmotic gradient ektacytometry: A valuable screening test for hereditary spherocytosis and other red blood cell membrane disorders.

abstract：:Chronic active Epstein-Barr virus infection of T- and NK-cell type, systemic form, is a rare entity within the spectrum of EBV-driven T- and NK-cell lymphoproliferative disorders. Established diagnostic criteria and a characteristic clinical course help to differentiate it from other closely related EBV-positive neopl...

journal_title：International journal of laboratory hematology

authors： Ondrejka SL,Hsi ED

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:To observe changes in the complete blood count (CBC) venous blood parameters of healthy children and establish appropriate reference intervals (RIs). METHODS:Overall, 4066 healthy children were selected and divided into four groups: infants, toddlers, preschool-age children and school-age children. Venous b...

journal_title：International journal of laboratory hematology

authors： Li J,Zhang H,Huang X,Zhang J,Wu X

更新日期：2019-10-01 00:00:00

abstract：:Bone marrow aspiration and biopsy can be a painful procedure. Sedation techniques may make this investigation more acceptable to patients, but have the potential to cause life-threatening complications, as well as requiring additional staff and equipment for safe administration. We assessed the use of Entonox, a 50 : ...

journal_title：International journal of laboratory hematology

authors： Gudgin EJ,Besser MW,Craig JI

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:The complete blood count (CBC) with differential leukocyte count (DIFF) is an important part of clinical laboratory analyses and provides crucial data for clinicians. Delivery time after blood collection and conditions of storage is known to affect the reliability of results of some hematologic parameters....

journal_title：International journal of laboratory hematology

authors： Cornet E,Behier C,Troussard X

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:FVIII inhibitors consist of a polyclonal population of antibodies. Previous studies have demonstrated different distribution of IgG subclasses. IgG4 was associated to high level of FVIII inhibitors and failure of immune tolerance induction (ITI) treatment. This study monitored the relative distribution of ...

journal_title：International journal of laboratory hematology

authors： Irigoyen MB,Primiani L,Felippo M,Candela M,de Bracco MME,Galassi NV

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Several factors influence the severity of Plasmodium falciparum; here, we investigate the impact of alpha+-thalassaemia genotype on P. falciparum parasitemia and prevalence of severe anaemia amongst microcytic children from Kumasi, Ghana. METHODS:Seven hundred and thirty-two children (≤10 years) with P. f...

journal_title：International journal of laboratory hematology

authors： Opoku-Okrah C,Gordge M,Kweku Nakua E,Abgenyega T,Parry M,Robertson C,Smith CL

更新日期：2014-02-01 00:00:00

abstract：:The value of nontransferrin-bound iron (NTBI) as an index of iron overload in patients with thalassemia has been evaluated; however, data in patients with sickle cell disease (SCD) is limited. NTBI levels were evaluated in a cross-sectional study of 43 transfused patients with SCD. Patient charts were reviewed for dem...

journal_title：International journal of laboratory hematology

authors： Inati A,Musallam KM,Cappellini MD,Duca L,Taher AT

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:The STA R Max® 2 is a new coagulation analyser developed by Diagnostica Stago, able to perform clotting, chromogenic and immuno-turbidimetric tests. A pre-analytical module build into the cap-piercing needle performs the sample integrity verification (sample tube filling and measurement of haemolysis, icte...

journal_title：International journal of laboratory hematology

authors： Cupaiolo R,Govaerts D,Blauwaert M,Cauchie P

更新日期：2019-12-01 00:00:00

abstract：INTRODUCTION:Laboratory investigations for bleeding disorders are warranted when an individual has a personal and/or family history of bleeding, and/or laboratory findings that suggest the possibility of an inherited or acquired bleeding disorder. METHODS:This review summarizes author's experience with ordering and re...

journal_title：International journal of laboratory hematology

authors： Hayward CPM

更新日期：2018-05-01 00:00:00

abstract：:Molecular monitoring of the BCR-ABL1 transcript in chronic myelogenous leukemia (CML) using quantitative real-time PCR (RQ-PCR) can be performed using either bone marrow (BM) or peripheral blood (PB). However, a recent report by Stock et al. [International Journal of Oncology 28 (2006) 1099] questioned the reliability...

journal_title：International journal of laboratory hematology

authors： Ballestrero A,Cirmena G,Dominietto A,Garuti A,Rocco I,Cea M,Moran E,Nencioni A,Miglino M,Raiola AM,Bacigalupo A,Patrone F

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:The blood count provides qualitative and quantitative essential information on bloodlines. Reference hematologic parameters have been established in children and neonates, but few data are available regarding the premature population during the first month of life. The main objective of this study was to e...

journal_title：International journal of laboratory hematology

authors： Roudil P,Vasselon C,Trombert-Paviot B,Berger C,Patural H

更新日期：2017-06-01 00:00:00

abstract：:Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of δβ thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of fe...

journal_title：International journal of laboratory hematology

authors： Stephens AD,Angastiniotis M,Baysal E,Chan V,Davis B,Fucharoen S,Giordano PC,Hoyer JD,Mosca A,Wild B,International Council for The Standardisation of Haematology (ICSH).

更新日期：2012-02-01 00:00:00

abstract：:The pathogenesis of acute myeloid leukaemias (AML) frequently requires at least 3 mutations in different cellular pathways. In many cases, mutations in proliferation/survival mechanisms and differentiation pathways are involved. Genetic aberrations explain the pathogenesis of AML, provide prognostic criteria and guide...

journal_title：International journal of laboratory hematology

authors： Merino A,Boldú L,Ermens A

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Monitoring of factor IX (FIX) replacement therapy in haemophilia B relies on accurate coagulation assays. However, considerable interlaboratory variability has been reported for one-stage clotting (OSC) assays. This study aimed to evaluate the real-world, interlaboratory variability of routine FIX activity...

journal_title：International journal of laboratory hematology

authors： Sommer JM,Sadeghi-Khomami A,Barnowski C,Wikén M,Willemze AJ

更新日期：2020-06-01 00:00:00

abstract：:Three major types of rearrangements are involved in acute myeloid leukemias (AML): t(8;21)(q22;q22), inv(16)(p13q22), and 11q23/MLL abnormalities. Their precise identification becomes essential for diagnosis, prognosis, and therapeutic choices. Resulting fusion transcripts (FT) are also powerful markers for monitoring...

journal_title：International journal of laboratory hematology

authors： Giusiano S,Formisano-Tréziny C,Benziane A,Maroc N,Picard C,Hermitte F,Taranger-Charpin C,Gabert J

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:The direct thrombin inhibitor dabigatran interferes with thrombophilia screening and with the diagnosis of hemostasis disorders that develop during treatment with the anticoagulant. In vitro addition of idarucizumab, a humanized antibody fragment that binds dabigatran, to plasma samples containing dabigatr...

journal_title：International journal of laboratory hematology

authors： Jacquemin M,Toelen J,Feyen L,Schoeters J,Van Horenbeeck I,Vanlinthout I,Debasse M,Vanassche T,Peerlinck K,Verhamme P

更新日期：2018-08-01 00:00:00

abstract：:Promoter hypermethylation plays an important role in the inactivation of cancer-related genes. This abnormality occurs early in leukemogenesis and seems to be associated with poor prognosis in myelodsplastic syndrome (MDS). The identification of more inactivated tumor suppressor genes contributing to the development o...

journal_title：International journal of laboratory hematology

authors： Qian J,Yao DM,Lin J,Wang YL,Han LX,Xu WR,Wu CY

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Presence of schistocytes in peripheral blood smear supporting haemolysis is important for diagnosis and decision-making in paediatric haemolytic uraemic syndrome (HUS). High observer dependency and requirement of expertise for peripheral smear evaluation propels us to think of other modalities to overcome ...

journal_title：International journal of laboratory hematology

authors： Govindarajan S,Bhatia P,Dawman L,Tiewsoh K

更新日期：2021-02-01 00:00:00

abstract：INTRODUCTION:Lupus anticoagulant (LAC) testing is a multistep procedure including screening, mixing, and confirmation tests. STA Coag Expert is a software module for STA R Max and STA Compact Max analyzers which includes an on-demand LAC algorithm, based on ISTH guidelines, for automatic interpretation, calculation, an...

journal_title：International journal of laboratory hematology

authors： Florin L,Desloovere M,Devreese KMJ

更新日期：2019-06-01 00:00:00

abstract：INTRODUCTION:To study the effect of bortezomib alone or in combination with daunorubicin (DNR) on an mdr1 single-factor drug-resistant leukemia cell line K562/MDR1, a multifactor-resistant cell line K562/A02, a drug-sensitive cell line K562, and primary cells from acute myeloid leukemia patients. METHODS:The cell line...

journal_title：International journal of laboratory hematology

authors： Zheng B,Zhou R,Gong Y,Yang X,Shan Q

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:In acute myeloid leukemia (AML), it has been shown that AML-derived cells often remain sensitive to autophagy-inducing stimuli, leading to the idea that harnessing the autophagy can be pertinent to AML cytotoxic therapy. Despite this promising notion, to date, there is no comprehensive study addressing aut...

journal_title：International journal of laboratory hematology

authors： Zare-Abdollahi D,Safari S,Movafagh A,Ghadiani M,Tabarraee M,Riazi-Isfahani S,Gorji S,Keyvan L,Gachkar L

更新日期：2016-04-01 00:00:00

abstract：:Complex chromosomal aberrations (CCA) can be detected in a substantial proportion of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), which are associated with very poor prognosis. Conventional cytogenetics (CC) cannot accurately define the specific alterations in CCA. Multiplex fluorescence in situ h...

journal_title：International journal of laboratory hematology

authors： Xu W,Li JY,Liu Q,Zhu Y,Pan JL,Qiu HR,Xue YQ

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:The Sysmex XP-300(®) (XP-300) is a new, fully automated hematology analyzer, designed to generate complete blood counts (CBC) with 3-part differential. In our study, the XP-300 was evaluated as a point-of-care (POC) analyzer in an oncology setting. In which blood samples from patients with different pathol...

journal_title：International journal of laboratory hematology

authors： van Dievoet MA,Louagie H,Ghys T

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:In daily practice in haematology laboratories, red blood cell (RBC) abnormalities are frequent and their management is a real challenge. The aim of this study is to establish a "decision tree" using RBC and reticulocyte parameters from the SYSMEX XN-10 analyser to distinguish between patients with a heredi...

journal_title：International journal of laboratory hematology

authors： Nivaggioni V,Bouriche L,Coito S,Le Floch AS,Ibrahim-Kosta M,Leonnet C,Arnoux I,Loosveld M

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:In order to correctly manage the paediatric patients affected with haemostatic disorders, age-appropriate reference intervals should be used. The purpose of this study was to establish age-specific reference intervals for prothrombin time (PT), thrombin time (TT), activated partial thromboplastin time (aPT...

journal_title：International journal of laboratory hematology

authors： Liu J,Dai Y,Yuan E,Li Y,Wang Q,Wang L,Su Y

更新日期：2019-10-01 00:00:00

abstract：INTRODUCTION:Aberrant activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway leads to deregulated proliferation, differentiation, or apoptosis of normal cells. One of the members of this family, JAK2, plays a very important role in metabolizing carcinogens and medications. This...

journal_title：International journal of laboratory hematology

authors： Zhong Y,Wu J,Ma R,Cao H,Wang Z,Ding J,Cheng L,Feng J,Chen B

更新日期：2012-06-01 00:00:00

abstract：:Blood coagulation factor XIII (FXIII) plays a key role in the protection of fibrin clot against fibrinolysis, in the cross-linking of fibrin and its mechanical strength. The role of the FXIII-A subunit Val34Leu polymorphism with fatal primary intracerebral hemorrhages (PICH) has not been studied. We evaluated retrospe...

journal_title：International journal of laboratory hematology

authors： Antalfi B,Pongrácz E,Csiki Z,Mezei ZA,Shemirani AH

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:It has been recently suggested that microparticles (MP) play a role in the pathogenesis of thrombotic complications. This study aimed to assess the contribution of procoagulant activity expressed by circulating MP in thrombotic events in MPN patients. METHODS:Seventy-four MPN patients were enrolled in a t...

journal_title：International journal of laboratory hematology

authors： Baccouche H,Ben Jemaa M,Chakroun A,Chadi S,Mahjoub S,Sfar I,Gorgi Y,Ben Romdhane N

更新日期：2017-10-01 00:00:00

abstract：:Prediction of the timing of platelet recovery after chemotherapy and hematopoietic stem cell transplantation (HSCT) allows for optimal platelet transfusion. We assessed the clinical utility of the percentage value of the immature platelet fraction (IPF%) monitored using an XE-2100 automated hematology analyzer to pred...

journal_title：International journal of laboratory hematology

authors： Yamaoka G,Kubota Y,Nomura T,Inage T,Arai T,Kitanaka A,Saigo K,Iseki K,Baba N,Taminato T

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Thrombocytopenia-absent radius (TAR) syndrome is a rare autosomal recessive disease. Patients are compound heterozygotes for a loss-of-function allele, which in most cases is a large genomic deletion on chromosome 1q21.1 containing the RBM8A gene, and a noncoding variant located in the 5'UTR (rs139428292) ...

journal_title：International journal of laboratory hematology

authors： Nicchia E,Giordano P,Greco C,De Rocco D,Savoia A

更新日期：2016-08-01 00:00:00